V
Vincent B. Young
Researcher at University of Michigan
Publications - 265
Citations - 23390
Vincent B. Young is an academic researcher from University of Michigan. The author has contributed to research in topics: Clostridium difficile & Microbiome. The author has an hindex of 71, co-authored 238 publications receiving 18715 citations. Previous affiliations of Vincent B. Young include Harvard University & University of Washington.
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Journal ArticleDOI
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
Mahesh Desai,Mahesh Desai,Anna M. Seekatz,Nicole M. Koropatkin,Nobuhiko Kamada,Christina A. Hickey,Mathis Wolter,Nicholas A. Pudlo,Sho Kitamoto,Nicolas Terrapon,Arnaud Muller,Vincent B. Young,Bernard Henrissat,Paul Wilmes,Thaddeus S. Stappenbeck,Gabriel Núñez,Eric C. Martens +16 more
TL;DR: Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium.
Journal ArticleDOI
The gut microbiome in health and in disease
TL;DR: There is a fast growing collection of data describing the structure and functional capacity of the microbiome in a variety of conditions available to the research community for consideration and further exploration.
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Decreased Diversity of the Fecal Microbiome in Recurrent Clostridium difficile—Associated Diarrhea
Ju Young Chang,Dionysios A. Antonopoulos,Apoorv Kalra,Adriano R. Tonelli,Walid Khalife,Thomas M. Schmidt,Vincent B. Young +6 more
TL;DR: The fecal communities in patients with recurrent CDAD were highly variable in bacterial composition and were characterized by markedly decreased diversity, suggesting preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrentCDAD.
Journal ArticleDOI
Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD
John R. Erb-Downward,Deborah L. Thompson,MeiLan K. Han,Christine M. Freeman,Christine M. Freeman,Lisa McCloskey,Lisa McCloskey,Lindsay A. Schmidt,Vincent B. Young,Galen B. Toews,Galen B. Toews,Jeffrey L. Curtis,Jeffrey L. Curtis,Baskaran Sundaram,Fernando J. Martinez,Gary B. Huffnagle +15 more
TL;DR: The data suggests the existence of a core pulmonary bacterial microbiome that includes Pseudomonas, Streptococcus, Prevotella, Fusobacterium, Haemophilus, Veillonella, and Porphyromonas within the same lung of subjects with advanced COPD.
Journal ArticleDOI
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
Casey M. Theriot,Mark J. Koenigsknecht,Paul E. Carlson,Gabrielle E. Hatton,Adam M. Nelson,Bo Li,Gary B. Huffnagle,Jun Li,Vincent B. Young +8 more
TL;DR: It is shown that antibiotic treatment induces substantial changes in the gut microbial community and in the metabolome of mice susceptible to C. difficile infection, which indicates that antibiotic-mediated alteration of the gut microbiome converts the global metabolic profile to one that favors C.difficile germination and growth.