Showing papers in "Experimental Eye Research in 1975"

TL;DR: These findings indicate that intrinsic differences exist in different regions of the retina in the rate of retinal dystrophy, and black eye pigment slows the progression of the disease as much as does dark-rearing in pink-eyed rats, and the very small amount of eye pigment inPink-eyed RCS rats is ineffectual in slowing the rateof the disease from that in albino RCS-c rats.

TL;DR: Cytologic details of the lens cells of the human and monkey have been studied with specific emphasis on their maturation process, finding no specific structural difference between lenses of different age groups.

TL;DR: The values, which are above the calculated equilibrium concentration, indicate that binding of calcium occurs, and the role of calcium is particularly interesting.

TL;DR: Osmotically intact discs from retinal rod outer segments are prepared by osmotic shock followed by flotation on 5% Ficoll to achieve high purity and integrity.

TL;DR: It is concluded that the precisely ordered spacing of collagen fibres in the cornea is determined by specific molecular constraints imposed by the conformation of keratan sulfate proteoglycan, further evidence that the organization of collagen Fibres is controlled by proteoglycans.

TL;DR: In vivo transcorneal freezing was used to destroy two-thirds of the endothelial cells in monkey cornea and the sequential process of repair was studied by biomicroscopy, pachometry, scanning and transmission electron microscopy, suggesting this may be a better model for studies of endothelial regeneration than is the rabbit cornea.

TL;DR: Electrophoretic analysis of the urea-insoluble plasma membrane-rich fraction in 5·13% polyacrylamide gels containing 1% sodium dodecyl sulfate (SDS) showed it to consist of seven major polypeptide components of estimated molecular weights.

TL;DR: The development of the human eye during the embryonic period proper (first 8 postovulatory weeks) is summarized, with particular emphasis on embryonic stages.

TL;DR: It is concluded that the 43 000 dalton polypeptide is composed of two smallerpolypeptides linked by a fluorescent component via their N-terminal groups, glycine and proline.

TL;DR: The endothelium lining the trabecular aspect of Schlemm's canal remained in close contact with the underlying meshwork throughout the pressure range and cellular rather than extracellular contacts were thought to be the major anchoring mechanism.

TL;DR: The present evidence indicates that the site of disruption of the blood-aqueous barrier occurs within the ciliary processes and not in the iris, and the breakdown in theBlood-aquesous barrier is at least partly mediated by this autacoid.

TL;DR: All three conditions exhibit similar defects of the endothelium and Descemet's membrane, plus stromal abnormalities with variable enlargement of collagen fibrils, which suggest the occurrence of related developmental disorders of the corneogenic mesenchyme.

TL;DR: The graded preservation of the meshwork is attributed to diffusion of oxygen from the packed erythrocytes in the dilated canal of Schlemm.

TL;DR: Binding ofretinol to the tissue receptor appears to be reversible and non-covalent; retinal and retinoic acid have little effect on the retinol-receptor interaction.

TL;DR: Lens cells of congenital mouse cataract (Nakano and Fraser strains) and galactose-fed rats were studied by scanning electron microscopy and numerous shrunken fibers are present among swollen cells in both congenital and galactoractous lenses.

TL;DR: Haluronidase-sensitive acid mucopolysaccharides were identified in the outflow apparatus of three primate species and the rabbit using colloidal thorium and colloidal iron for electron microscopy and the possible influence of mucopoly Saccharides on outflow resistance was discussed.

TL;DR: It is suggested that, prior to phagocytosis in normal animals, the pigment epithelium recognizes specific sites on the plasma membrane of discarded outer segment discs that are frequently removed in artificially prepared outer segment fragments either through the washing away of soluble components or removal of the enveloping plasma membrane.

TL;DR: Analysis of the damage suggests that the melanin granules were transiently raised to very high temperatures which resulted in the production of acoustic and shock waves within the retina.

TL;DR: The outer segment enzyme would serve to interconvert retinaldehyde and retinol during the photolytic cycle, and the pigment epithelium enzyme possibly functions to return 11- cis retinal dehyde to the pool of vitamin A compounds needed during the rod renewal process.

TL;DR: Estimates indicate that no more than 50% of the rhodopsin is contained in surviving visual cells at the age of 25 days, only 25% at 35 days and virtually none at 80 days, while maintenance on a vitamin A deficient diet accelerates the rate of visual cell death and ERG decline as early as 12 days after withholding vitamin A from weaned B rats.

TL;DR: In cats 2–10 μg/kg body weight clonidine given intravenously reduced the intrascleral venous pressure and the eye pressure in a way which indicated marked vasoconstriction in the eye.

TL;DR: In this article, the isolation and partial characterization of four polypeptide chains of β-crystallin is described and three of them can be obtained both from β H and β L.

TL;DR: The birefringence of bovine lens was found to be very small, of the order of 10 −6 –10 −7 , and it is proposed that this optical isotropy, that enhances transparency, is due to the fact that the form bireFringence and the intrinsic bire fringence cancels each other.

TL;DR: Following occlusion of two major retinal veins in a rhesus monkey, areas of retinal non-perfusion developed and these areas became gradually revascularized over the subsequent 5 months.

TL;DR: F fused membranes were most distinct and even more frequent in the lens nucleus than in the cortex, and the junctions were generally also here of the gap-junction type.

TL;DR: The calcium in the pigmented epithelium exceeds that in muscle and is as great as that in platelets, which have been considered to be high calcium cells in which calcium plays a role in several cell functions.

TL;DR: Three different adrenergic beta-blockers administered orally in the minimal amount necessary to produce a decrease in blood pressure were able to cause an immediate and significant decrease in IOP which lasted throughout the period of administration (8 days).

TL;DR: It is proposed that genetically controlled induction of the hydroxylase activity and perhaps other cytochrome P-450-mediated mono-oxygenase activities in the retinal pigmented epithelium-choroid play an important role for detoxification and/or metabolic potentiation of drugs and other xenobiotics.

TL;DR: Cathepsin D in the retinal pigment epithelium of the bovine eye was studied using standard enzymological techniques and revealed the highest specific activity, the activity being highest in the lysosomal fraction.