H
Haiko J. Bloemendal
Researcher at Radboud University Nijmegen
Publications - 182
Citations - 6649
Haiko J. Bloemendal is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Crystallin & Prostate cancer. The author has an hindex of 42, co-authored 167 publications receiving 5624 citations. Previous affiliations of Haiko J. Bloemendal include Netherlands Cancer Institute & Utrecht University.
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Journal ArticleDOI
Pan-cancer whole-genome analyses of metastatic solid tumours
Peter Priestley,Jonathan Baber,Martijn P. Lolkema,Neeltje Steeghs,Ewart de Bruijn,Charles Shale,Korneel Duyvesteyn,Susan Haidari,Arne Van Hoeck,Wendy Onstenk,Paul Roepman,Mircea Voda,Haiko J. Bloemendal,Vivianne C. G. Tjan-Heijnen,Carla M.L. van Herpen,Mariette Labots,Petronella O. Witteveen,Egbert F. Smit,Stefan Sleijfer,Emile E. Voest,Edwin Cuppen +20 more
TL;DR: The largest, to the authors' knowledge, pan-cancer study of metastatic solid tumour genomes, including whole-genome sequencing data for 2,520 pairs of tumour and normal tissue pairs, analysed at median depths of 106× and 38×, respectively, and surveying more than 70 million somatic variants is described.
Journal ArticleDOI
Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.
Salo N. Ooft,Fleur Weeber,Krijn K. Dijkstra,Chelsea M. McLean,Sovann Kaing,Erik van Werkhoven,Luuk J. Schipper,L.R. Hoes,Daniel J. Vis,Joris van de Haar,Warner Prevoo,Petur Snaebjornsson,Daphne L. van der Velden,Michelle Klein,Myriam Chalabi,Henk Boot,Monique E. van Leerdam,Haiko J. Bloemendal,Laurens V. Beerepoot,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Edwin Cuppen,Hans Clevers,Emile E. Voest +23 more
TL;DR: An in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify nonresponders to standard-of-care chemotherapy in colorectal cancer (CRC) is developed and the feasibility of generating and testing PDOs for evaluation of sensitivity to chemotherapy is shown.
Journal ArticleDOI
Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones.
Karin B. Merck,Patricia J. T. A. Groenen,Christina E.M. Voorter,W. A. De Haard-Hoekman,J. Horwitz,Haiko J. Bloemendal,W.W. de Jong +6 more
TL;DR: It is shown that alpha-crystallin and HSP25 resemble each other in secondary structure and have similar stability toward urea dissociation at pH 7.0, and H SP25 is found to be a substrate for protein cross-linking by tissue-type transglutaminase, like alpha B- Crystallin.
Journal ArticleDOI
The mechanism of N-terminal acetylation of proteins.
TL;DR: N alpha-acetylation is almost exclusively restricted to eukaryotic structural proteins and appears to have a narrow substrate specificity, which is very similar for enzymes from different tissues and species.
Journal ArticleDOI
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.
Lindsay Angus,Marcel Smid,Saskia M Wilting,Job van Riet,Arne Van Hoeck,Luan Nguyen,Serena Nik-Zainal,Tessa G Steenbruggen,Vivianne C. G. Tjan-Heijnen,Mariette Labots,Johanna M. G. H. van Riel,Haiko J. Bloemendal,Neeltje Steeghs,Martijn P. Lolkema,Emile E. Voest,Harmen J.G. van de Werken,Agnes Jager,Edwin Cuppen,Stefan Sleijfer,John W.M. Martens +19 more
TL;DR: Whole-genome sequencing of metastatic biopsies from 442 patients with breast cancer provides insights into metastatic disease, including associations of genomic features with prior treatments and identification of therapeutic vulnerabilities.