Showing papers in "Experimental Neurology in 2022"

TL;DR: In this paper, exosomes derived from rhesus monkey mesenchymal stromal cells (MSC-Exo) were used for demyelination in mice.

TL;DR: In this paper , exosomes derived from rhesus monkey mesenchymal stromal cells (MSC-Exo) were used to treat demyelination in the adult central nervous system (CNS).

TL;DR: In this paper , a review summarizes the current state of machine learning studies for invasive neurophysiology and concludes by identifying four key ingredients on the road for successful clinical adoption: i) multidisciplinary research teams, ii) publicly available datasets, iii) open-source algorithmic solutions and iv) strong world-wide research collaborations.

TL;DR: In this article , the authors quantified occurrence and identified determinants of spectral peaks in the alpha, low and high beta bands in a large dataset of postoperative rest recordings from 106 patients and found that at least one peak in the high beta band occurred in 92% of patients and 84% of hemispheres off medication.

TL;DR: In this article, the authors review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia.

TL;DR: A review of recent findings from preclinical and clinical studies that evaluated the central effects of MDMA, and the mechanisms involved in the neurotoxicity induced by this amphetamine-related drug can be found in this paper.

TL;DR: A review of recent findings from preclinical and clinical studies that evaluated the central effects of MDMA, and the mechanisms involved in the neurotoxicity induced by this amphetamine-related drug can be found in this article .

TL;DR: In this article , the authors review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia.

TL;DR: Zhang et al. as mentioned in this paper found that 8 weeks of high-fat feeding effectively induced metabolic disorders, including obesity and hyperlipidemia in mice, and the mice also showed depressive and anxiety-like behaviors.

TL;DR: In this paper , a selective CB2 agonist, JWH133, protected white matter after Traumatic Brain Injury (TBI) using diffusion tensor imaging (DTI) and transmission electron microscopy (TEM).

TL;DR: It is confirmed that a selective CB2 agonist, JWH133, protected white matter after TBI and alleviates WMI and improves neurological behavior following TBI.

TL;DR: In this paper , the authors highlight the main intrinsic and extrinsic regulators of neural stem cell function under homeostatic and inflammatory conditions including those trafficked within extracellular membrane vesicles.

TL;DR: In this paper , the effect of exosomes from mesenchymal stem cells (LPS pre-MSCs) on peripheral nerve regeneration and axon regeneration was investigated.

TL;DR: In this article , the role of endogenous IL-4 during nerve injury and regeneration in vivo was assessed following a sciatic nerve crush using interleukin-4 knockout (KO) mice.

TL;DR: In this paper, the role of endogenous IL-4 during nerve injury and regeneration in vivo was assessed following a sciatic nerve crush using interleukin-4 knockout (KO) mice.

TL;DR: In this article , the role of Schwann cells and macrophage secretomes on Wallerian degeneration and axonal regeneration after peripheral nerve injury was described. But the most used secretome in neural therapies has been the one derived from mesenchymal (MSC) or other derived stem cells.

TL;DR: In this article , fine-tuned gamma (FTG) oscillations have been observed in multiple movement disorders and are induced by dopaminergic medication or deep brain stimulation (DBS), which makes it a putative biomarker for adaptive DBS.

TL;DR: In this paper , a detailed spiking model of the basal ganglia was implemented and combined with TVB via a co-simulation environment to predict the effects of DBS.

TL;DR: This literature review focuses on the underlying pathophysiology of TBI and PTSD symptoms, while also examining the plethora of stem cell treatment options to ameliorate these neuronal and functional changes.

TL;DR: In this paper , the authors presented a comprehensive phenotype of post-traumatic epilepsy after contusion brain injury in mice, which exhibits robust spontaneous seizures along with neuronal loss, inflammation, and cognitive dysfunction.

TL;DR: The DyNeuMo Mk-1 system was designed, manufactured and verified using ISO 13485 design controls, including ISO 14971 risk management techniques to ensure patient safety, while enabling novel algorithms as mentioned in this paper .

TL;DR: In this article , an age-dependent alteration of cell excitability and firing in pyramidal neurons starting at 3 months of age was found, which correlates with reduced levels in the ventral CA1 of tyrosine hydroxylase -the rate-limiting enzyme of DA synthesis.

TL;DR: Based on the observation of protein functions, the activity of many different proteins encoded by HSP-related genes converges into some distinct pathophysiological mechanisms, which suggests that common pathways could be a potential target for a therapy, possibly addressing several forms at once as mentioned in this paper .

TL;DR: In this article , a system biology approach incorporating ante-and post-natal risk factors and analyzing omic and multi-omic data using machine learning is proposed for further elucidating biologic mechanisms of fetal and neonatal brain injury.

TL;DR: In this paper, the root mean square (RMS) of the right and left diaphragm, 2nd parasternal, scalene and sternocleidomastoid muscles were monitored, and a vector analysis was used to calculate summated vector magnitude (Mag) and similarity index (SI) of collective EMG activity during quiet breathing, SNIP and maximal inspiratory pressure (MIP) maneuvers.

TL;DR: In this article , a review of early and recent reports from patients and animal models evaluating the etiology of Parkinson's disease insomnia is presented, along with emerging neuromodulation-based therapeutic avenues for PD insomnia.

TL;DR: In 2018, the US Food and Drug Administration approved the first phytocannabinoid, cannabidiol (CBD, Epidiolex), which is now indicated for severe seizures associated with three rare forms of developmental and epileptic encephalopathy: Dravet syndrome, Lennox-Gastaut syndrome, and tuberous sclerosis complex as discussed by the authors .

TL;DR: In this article , a review summarizes the current knowledge of EVs in the context of the healthy and injured peripheral nerve and addresses novel concepts for modification of EVs as therapeutic agents for peripheral nerve regeneration.

TL;DR: In this article , the role of PPARγ in neuronal ferroptosis induced by traumatic brain injury (TBI) was investigated in a weight-drop TBI model in vivo and an RAS-selective lethal 3 (RSL3)-activated neuronal model in vitro.

TL;DR: In this article , the role of CA-074, a potent Cathepsin B inhibitor, in MS progression was investigated using the SJL/J mouse model of experimental autoimmune encephalomyelitis (EAE).