Showing papers in "Frontiers in Laboratory Medicine in 2017"

TL;DR: This review presents the application of molecule targeted therapy in cancer treatment and a particular focus is on the potential mechanism that can facilitate further improvement of anticancer.

TL;DR: Cardiac troponins T and I are proteins released into serum after cardiac injury, and are the standard biomarkers for patients presenting to the emergency department with a suspicion of acute myocardial infarction (AMI).

TL;DR: In this article, the authors explore the value of t-test for internal quality control by analyzing a specific example and discover the inconsistency of two instruments by analyzing their IQC results with two paired samples T-test.

TL;DR: In this paper, a simple and original method to synthesize water-soluble gold nanoparticles in which a polyphenolic fraction, extracted by two plants originated from Reunion Island, was mixed to tetrachloroauric acid (HAuCl4) leading to shell-like hybrid flavonoid-metal nanoparticles (NPs).

TL;DR: Label-free methods are mainly based on the molecular biophysical properties without conjugated labels, which can largely avoid false positives and can provide more reliable and reproducible detection results.

TL;DR: The mechanisms of colistin resistance should provide an impetus for future research on the development of newer alternative therapies to treat emerging MDR A. baumannii infections when other antibiotics are ineffective.

TL;DR: Recent findings on functions of ECM microenvironment in mammary gland development, tumor growth, invasion, migration and metastasis are summarized, focusing on the functions of cancer cell-derived ECM in tumor progression.

TL;DR: Pseudomonas was the dominant genus among the upper respiratory tract bacterial flora in H1N1-infected patients and probably be closely related to the occurrence and progression of secondary bacterial infection.

TL;DR: FPG was significantly correlated with HbA1c and a significant increase in FPG and Hb a1c in male was observed by comparing with female and further longer term and large scale research in each age group is warranted.

TL;DR: In this paper, a one-step method based on UV irradiation was proposed to graft a bioactive polymer bearing sulfonate groups called poly(sodium styrene sulfonates) (polyNaSS) onto titanium nanoparticles (TiO2 NPs) through covalent bond.

TL;DR: High specificity of DOX IN PEG-AuNPs-DNA with a limit of detection (LOD) of 9 nM is demonstrated, which is very promising for development of sensitive and effective nanoparticle-based biosensor for quantifying small biomolecules concentration in physiological liquids.

TL;DR: The burn patients who infected MRSA have a higher drug resistance, and further recognition of the molecular characteristics of MRSA is necessary to find better treatment options.

TL;DR: The structure, biological function and role of the miR-590 gene, a class of non-coding single small RNAs transcribed from Eukaryotic genes, is summarized.

TL;DR: This paper will review the latest research about p62 protein in Atherosclerosis in order to provide a reference for further understanding of the occurrence and development of atherosclerosis.

TL;DR: A systematic review and meta-analysis of studies investigating the clinical values, including prognosis and clinicopathology of different lncRNAs in GC indicated that the levels of lnc RNAs were associated with the OS.

TL;DR: The mitochondrial UPR mt is a response of the cell to relieve mitochondrial damage and respond to proteotoxic stress specifically in mitochondria, which can sustain proteostasis and maintain overall cellular homeostasis.

TL;DR: The combination of NAT and ELISA could effectively improve the detection accuracy and screening efficiency for HIV, HBV and HCV, decrease the rate of missed detection, and reduce the risk of iatrogenic infection.

TL;DR: MALDI-TOF MS identification following the direct smear technique appears to be non-inferior to standard chemical extraction and may be an acceptable alternative to chemical extraction methods for routine identification of anaerobic bacteria in a medical microbiology laboratory.

TL;DR: In this paper, the synthesis of hybrid silver nanostructures (AgNPs) based on an effective mixing of polyols with Polyvinylpyrrolidone (PVP) and Porphyrin molecules, in particular Protoporphrin IX (PP) was reported.

TL;DR: Mindray BS-2000M has achieved the desirable photometry technical and analytical performance, and can therefore be used in modern clinical laboratories.

TL;DR: This case highlighted the potential role of K. gyiorum in wound infection from limbs and a rising number of this organism will probably be reported in future with the promotion of MALDI–TOF MS and 16S rRNA gene sequencing in clinical laboratories.

TL;DR: The results demonstrated that hs-cTnI sandwich assay with the immunomagnetic microparticle and quantum dots-based multi-mAb approach is a sensitive, accurate, and quantitative method for the detection of disease biomarkers.

TL;DR: Investigation of the association of four single nucleotide polymorphisms with susceptibility to tuberculosis in Chinese Uyghur populations found that genetic factors in different ethnicity and genetic backgrounds may lead to different effects on tuberculosis risk.

TL;DR: Inter-combination analysis of three biomarkers has improved the performance of the assays and found that the preoperative and postoperative serum EGF and EGFR levels were significantly higher than in controls.

TL;DR: In Sichuan, the probability of women infected with HPV was very high and the target of prophylactic vaccine design should include HPV-52 and HPV-58, and appropriate preventive care and constructing effective vaccine should be based on close monitoring of regional HPV.

TL;DR: This demonstrates that the color modification observed with BP-PEG-AuNP is effectively due to an interaction between PAP and BP, and allows the rapid differential diagnosis with naked eye or image analyzer.

TL;DR: Although uncommon, fat embolism syndrome should be considered in the differential diagnosis of acute complications with hemoglobin SC disease.

TL;DR: It is demonstrated that the level of LHBs can efficiently reflect the replication status of the virus in patients with HBeAg-negative diseases, and the LHB assay support the HBV test.

TL;DR: Gaining a better perception of the relationship between gut flora and the depression and other related diseases, this complex parameter could provide a novel insight into the pathogenesis, clinical diagnosis and treatments in major depressive disorder.

TL;DR: APOC3 rs854116 and rs2854117 polymorphisms are associated with higher fasting TG level, respectively, and this association was significant in adult and Caucasian subgroup.