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Showing papers in "Gastroenterology in 1976"


Journal ArticleDOI
TL;DR: In this paper, a multiple regression computer program was utilized to derive an equation for prediction of the physician's over-all ratings from a subset of the predictor variables fulfilling a combination of constraints.

3,262 citations


Journal ArticleDOI
TL;DR: In a survey of 402 United States owners of side-viewing duodenoscopes surveyed, 222 responded, reporting 10,435 endoscopic retrograde cholangiopancreatograms as mentioned in this paper.

608 citations


Journal ArticleDOI
TL;DR: It is suggested, on the basis of the severity of the clinical symptoms, and on the pathological changes in the rectum, that the organism in this case is likely to have been the cause of the enterocolitis and thus to have was a pathogen rather than a commensal.

572 citations


Journal ArticleDOI
TL;DR: A 39-year-old man with severe bullous pemphigoid developed overwhelming diarrhea after 5 weeks' treatment with 150 mg of cyclophosphamide and 60 mg of prednisolone daily and may have predisposed this patient to cryptosporidial diarrhea.

446 citations


Journal ArticleDOI
TL;DR: The study of the development of the human GI tract is not a new science; many important and sophisticated observations date back more than 100 years as discussed by the authors. But the number of studies performed in the future may be seriously reduced by legislative limitations on the availability of appropriate tissue and the reluctance of pathologists and investigað tors to test the interpretations of ambiguous statutes.

426 citations



Journal ArticleDOI
TL;DR: The most direct evidence to date that luminal nutrition is essential for the development of intestinal adaptation after resection is provided and luminal contents are necessary to maintain the structural and functional integrity of the normal small bowel is suggested.

330 citations


Journal ArticleDOI
TL;DR: An animal model for giardiasis was developed using Giardia muris in Swiss albino mice, and those mice receiving inoculations of larger numbers of cysts showed earlier attainment of maximal counts, greater impariment of weight gain, and earlier and more severe small bowel changes than mice receiving smaller numbers of Cyst inoculum.

330 citations


Journal ArticleDOI
TL;DR: Using this method, acid, pepsin, and total secretory outputs; rates of gastric emptying of meal and secretions; and serum gastrin levels during digestion characterize physiological responses to ordinary food in health.

308 citations


Journal ArticleDOI
TL;DR: It is concluded that hyperglycemia does exert some effect on gastric emptying, but that these effects are variably expressed, depending on the presence of other factors which themselves slow gastric emptied.

258 citations


Journal ArticleDOI
TL;DR: It has been demonstrated previously that colonic responsiveness to certain stimuli was increased during the slower frequency BER, and it is suggested that the abnormalities in Colonic motor response reported in the irritable bowel syndrome may be related to this difference in colonic BER.

Journal ArticleDOI
TL;DR: An awareness of his patient's psychiatric illness is necessary for the physician to provide effective treatment, as for depression, and to spare the patient needless medications, hospitalizations, and surgery, as with hysteria.

Journal ArticleDOI
TL;DR: Results suggest that 15-methyl PGE2 and 16,16-dimethyl P GE2 may be of value in the treatment of peptic ulcer.

Journal ArticleDOI
TL;DR: The results suggest that bile salts and fatty acids increase colonic absorption of oxalate, and may further explain many of the clinical phenomena associated with enteric hyperoxaluria.

Journal ArticleDOI
TL;DR: In patients who had undergone Billroth II gastrectomy there was no evidence of differential emptying of the two markers, and measurements of early emptying and of solid-liquid differentiation are necessary for full definition of gastric emptying after ingestion of a mixed solid and liquid meal.

Journal ArticleDOI
TL;DR: Detailed metabolic studies are presented and the data include routine biochemical analyses, liver function tests, liver biopsy results, blood aminograms, the plasma phospholipid fatty acid pattern, the Plasma lipoprotein pattern, and blood vitamin and trace element profiles.

Journal ArticleDOI
TL;DR: The most sensitive and specific test combination for the diagnosis of reflux esophagitis appears to be esophageal biopsy with esophAGEal pH study after HC1.

Journal ArticleDOI
TL;DR: Supporting evidence is provided for the hypothesis that circulating endotoxin can adversely affect hepatic function and may contribute to the production of intrahepatic cholestasis seen during bacterial infection.

Journal ArticleDOI
TL;DR: It is suggested that GE scintiscanning can detect GE reflux accurately, rapidly, noninvasively, and with greater sensitivity than other diagnostic techniques.

Journal ArticleDOI
TL;DR: It is concluded that these findings are consistent with (but do not establish) the hypothesis that dopamine is the neurotransmitter for receptive relaxation of the stomach, because dopamine mimics receptive relaxation, and dopamine antagonists partially block reflexly induced receptive relaxation.

Journal ArticleDOI
TL;DR: A prospective study of candida esophagitis was undertaken to determine the spectrum of this disease in a general hospital and found absence of titer precluded a diagnosis of Candida esophageal symptoms.

Journal ArticleDOI
TL;DR: The findings provide evidence that the site of SC synthesis in intestinal epithelium is secretory columnar cells, principally those in gland crypts and the polymeric immunoglobulins IgM and IgA are translocated through such SC-containing cells by a process that involves formation of cytoplasmic vesicles.

Journal ArticleDOI
TL;DR: These studies show that tetrodotoxin can be administered in intact animals to achieve complete block of neural activity in the lower esophageal sphincter, and spHincter muscle is not adversely affected by tetrodOToxin; and block of Neural activity does not alter the resting lower esphagealSphincters pressure.

Journal ArticleDOI
TL;DR: The cause of bleeding was found in 8 of 10 cases of colonic diverticulosis associated with severe rectal hemorrhage by using arteriographic and microangiographic techniques to localize the site and serial histological sections to study the lesion, and strikingly consistent changes were identified.

Journal ArticleDOI
TL;DR: In this paper, data for 500 patients with Crohn's disease who underwent operations were analyzed (316 patients, 1966 to 1969; 184 patients, 1972 to 1973) by comparison of various anatomic disease locations (clinical pattern): (1) ileocolic, 225 patients, small intestinal, 130 patients; (2) colonic, 127 patients; and (3) anorectal, 18 patients.

Journal ArticleDOI
TL;DR: The results show a significant relationship between the different degrees of accumulation of HBsAg and HBcAg in the liver and the various histological types of hepatitis and further suggest an interplay of both hepatitis B virus and host immune response in the development and pathogenesis of hepatitis B.

Journal ArticleDOI
TL;DR: Analysis of ileal fluid collected during passage of the lactose meal indicated that about two-thirds of the osmotic load delivered to the colon consists of endogenous electrolytes, which is about 3 times that calculated to be osmotically held by the nonabsorbed sugar.

Journal ArticleDOI
TL;DR: In indirect immunofluorescence tests, antibodies against pure porcine cholecystokinin (CCK) have detected specific CCK cells in the duodenal and jejunal mucosa of the dog and man as mentioned in this paper.

Journal ArticleDOI
TL;DR: Decompression of the biliary tree by anastomosis of the gallbladder or common duct to the small intestine completely relieved symptoms and allowed liver function to improve significantly.