Journal•ISSN: 1050-3862
Genetic Analysis: Biomolecular Engineering
Elsevier BV
About: Genetic Analysis: Biomolecular Engineering is an academic journal. The journal publishes majorly in the area(s): Gene & Oligonucleotide. It has an ISSN identifier of 1050-3862. Over the lifetime, 244 publications have been published receiving 7644 citations.
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TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.
1,443 citations
TL;DR: It is demonstrated that single-nucleotide differences in a DNA sequence can be detected in homogeneous assays using molecular beacons using four template DNAs that only differed from one another by the identity of the nucleotide at one position.
405 citations
TL;DR: The MoPrP.Xho vector should be very useful in strategies designed to overexpress a variety of wild-type and disease related mutant transgenes in the heart and brain.
352 citations
TL;DR: The principles of PCR-SSCP, guidelines for experiments, and applications of this technique in various fields are reviewed.
280 citations
TL;DR: Current approaches utilizing nonisotopic in situ hybridization for the analysis of linear and spatial genome organizations are presented and clinical applications of these approaches, which open new avenues for diagnosis of disease-related chromosomal changes are discussed.
235 citations