Showing papers in "Hepatology Research in 2008"

TL;DR: The Japanese HCC guidelines may be useful in decision making at every clinical step, both for patients and physicians, and the accumulated evidence and interpretation in the guidelines may attract universal attention.

TL;DR: This work investigated the transcriptional factors and lipogenic genes activated in the liver with NAFLD and found that SREBP‐1c and ChREBP are transactivated by liver X receptor (LXR), a nuclear receptor that regulates the metabolism of cholesterol and fatty acids.

TL;DR: Treatment with ursodeoxycholic acid (UDCA) improves the survival of stage I and II primary biliary cirrhosis patients and new therapeutic options are needed for patients who are refractory to UDCA and for those whose disease is at an advanced stage.

TL;DR: A nationwide survey was performed to clarify the present state of fulminant hepatitis and late onset hepatic failure between 1998 and 2003 in Japan.

TL;DR: Partial splenic embolization (PSE) is a non-surgical procedure developed to treat hypersplenism as a result of hepatic disease and thus avoid the disadvantages of splenectomy as discussed by the authors.

TL;DR: A fine‐powder cisplatin formulation was developed and tested in advanced hepatocellular carcinoma patients in an open‐label, uncontrolled study in which 27 institutions participated.

TL;DR: Despite the relatively good prognosis for acetaminophen overdoses, 30% die once acute liver failure occurs and this is the largest cause of death in the entire ALF registry.

TL;DR: Cyclosporine A is the most widely used immunosuppressive drug in transplant surgery and it is able to generate reactive oxygen species and cause lipid peroxidation, which will directly result in CsA hepatotoxicity.

TL;DR: Assessment of the role of galectin‐3 during HCC progression to assess the function and correlation with tumor progression remains unknown.

TL;DR: Because of Egypt's unique risk factor profile, data from the Gharbiah Population‐Based Cancer Registry for the period 1999–2003 was analyzed to characterize demographic and geographic patterns of cases.

TL;DR: This work summarizes the information collected thus far in the field of HCV molecular virology and principal intracellular signaling pathways in which HCV oncogenic proteins are involved.

TL;DR: The aim is to investigate the efficacy and toxicity of hypofractionated stereotactic radiotherapy for the treatment of patients presenting with hepatocellular carcinoma in a single institutional setting.

TL;DR: Hepatic encephalopathy remains a severe neuropsychiatric complication of liver failure and therapy for HE continues to rely heavily on strategies aimed at reduction of gut ammonia production, increased ammonia removal and, ultimately, liver transplantation.

TL;DR: Aim: A series of recent studies have indicated the presence of natural intergenotypic recombinant hepatitis C virus (HCV) strains in distinct parts of the world.

TL;DR: Interestingly, CC components of combined hepatocellular CC share the features of ductular CC, suggesting that hepatic progenitor cells may be involved in the tumorigenesis ofductular CC.

TL;DR: It is quite worthwhile to construct a specialized database for the hepatitis virus sequences and to make it accessible to researchers worldwide.

TL;DR: To investigate the diagnostic value for the diagnosis of small hepatic nodules detected by surveillance ultrasound in patients with cirrhosis using contrast‐enhanced ultrasound (CEUS) compared with that of contrast-enhanced helical computed tomography (CECT).

TL;DR: To improve the accuracy of liver fibrosis staging, the combination of transient elastography with other noninvasive methods such as FibroTest should be required.

TL;DR: This study aimed to test whether oxidative stress contributes to these mechanisms by which metabolic disorders develop in patients with chronic hepatitis C.

TL;DR: Evaluated the effectiveness of RVS for radiofrequency ablation therapy (RFA) of hepatocellular carcinomas (HCC) in which it was difficult to identify contours or margins by B‐mode US.

TL;DR: Deregulation of E2F1 transcriptional activity is observed in a variety of cancers, including hepatocellular carcinoma (HCC), and the aim of the present study is to identify transcriptional target genes of E 2F1 in HCC.

TL;DR: In chronic hepatitis C virus infection, it is thought that both chronic persistent inflammation and oxidative stress contribute to the development of hepatocellular carcinoma (HCC), and it has been reported that long‐term oral supplementation with branched‐chain amino acid (BCAA) granules could inhibit liver carcinogenesis.

TL;DR: An overview of the roles of liver‐enriched transcription factors in liver function is provided and a link between the extracellular matrix, changes in cytoskeletal filament assembly and hepatocyte differentiation via HNF‐4 has been shown to be involved in the transcriptional regulation of Liver‐specific gene expression.

TL;DR: Focusing on HCC development in patients in whom hepatitis C virus (HCV) eradication by interferon (IFN) therapy had failed, this study conducted this study in order to assess the impact of occult HBV infections on H CC development in these patients.

TL;DR: Aim: Previous studies have revealed that functional impairment of innate immune cells, including natural killer (NK) and natural killer T (NKT) cells, might be associated with the persistence of hepatitis C virus infection.

TL;DR: To determine whether the findings of microflow imaging (MFI), composed of a flash replenishment and a maximum intensity holding sequence, correlate with the degree of histological differentiation of hepatocellular carcinoma (HCC).

TL;DR: In this study, the usefulness of the Guideline was re‐evaluated, since the therapeutic strategies for fulminant hepatitis have advanced remarkably over the last 10 years.

TL;DR: Primary clear cell carcinoma of the liver (PCCCL) is a subgroup of primary hepatocellular carcinoma (HCC), pathologically characterized by diffuse clear cells of the tumor, showing a clear cytoplasm that does not stain with hematoxylin–eosin.

TL;DR: The aim was to test the anticancer effects of Rho/ROCK inhibitor, Y‐27632, including possible mechanisms in a highly‐metastasizing hepatocellular carcinoma mouse model on its secretion of matrix metalloproteinase (MMP) and tumor progression.

TL;DR: In patients with hepatitis C virus‐associated chronic liver diseases, especially in those with liver cirrhosis, accurate evaluation of their protein nutrition status is very important to improve their quality of life.