Journal ArticleDOI
An immunohistochemical study of human central and peripheral nervous system tumors, using monoclonal antibodies against neurofilaments and glial filaments.
TLDR
Findings indicate that monoclonal antibodies against intermediate filament proteins such as neurofilaments and glial filaments retain their specificity and sensitivity when employed in paraffin sections in conjunction with the peroxidase-antiperoxidases method.About:
This article is published in Human Pathology.The article was published on 1984-03-01. It has received 105 citations till now. The article focuses on the topics: Neurofilament & Neuroepithelial cell.read more
Citations
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Journal ArticleDOI
Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins
TL;DR: The number of neurofilament- positive cells increased with time after initial exposure to retinoic acid, and although 95% of these cells contained cytokeratin initially, less than 5% of the neuro Filament-positive cells retained cytokersatin 2 weeks later, suggesting that many of the cells expressing all three neurofilaments but no cytokerati exhibited a neuronal morphology.
Journal ArticleDOI
Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies.
TL;DR: It is suggested that the expression of all three NF subunits is a common feature of CNS and PNS neurons and their processes, and of some cells of the diffuse neuroendocrine system.
Journal ArticleDOI
Monoclonal antibodies to human intermediate filament proteins. III. Analysis of tumors.
Allen M. Gown,Arthur M. Vogel +1 more
TL;DR: A panel of monoclonal antibodies to human intermediate filament proteins was tested on an unselected series of 246 neoplasms and these antibodies are reliable diagnostic reagents that are useful in distinguishing different categories of human tumors.
Journal ArticleDOI
Diagnostic application of monoclonal antibodies to intermediate filaments.
TL;DR: New reagents include antibodies that enable us to identify specific cell types in tissue sections, such as endothelial cells, histiomonocytic cells, different types of lymphatic cells, epithelial Cells, neuronal cells, and muscle-type of cells.
Journal ArticleDOI
Monoclonal antibodies to gel-excised glial filament protein and their reactivities with other intermediate filament proteins.
TL;DR: Observations strongly suggest that the 51,000–dalton protein recognized by these four MAs was not derived from GF proteins but instead represents derivatives of NF protein subunits comigrating in gels with GF proteins.
References
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Journal ArticleDOI
Continuous cultures of fused cells secreting antibody of predefined specificity
G Köhler,C. Milstein +1 more
TL;DR: The derivation of a number of tissue culture cell lines which secrete anti-sheep red blood cell (SRBC) antibodies is described here, made by fusion of a mouse myeloma and mouse spleen cells from an immunised donor.
Journal ArticleDOI
Intermediate Filaments: A Chemically Heterogeneous, Developmentally Regulated Class of Proteins
TL;DR: Descmin Filaments: Integration oj Myojibrils at the Z Disc explores the role of keratin Filaments in the integration of proteins and their role in wound healing.
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All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody
TL;DR: It is suggested that all vertebrate and invertebrate intermediate filament proteins share a common antigenic determinant and the possibility that all intermediate filaments contain a 66,000 molecular weight protein.
Journal ArticleDOI
The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors.
TL;DR: It seems appropriate to call these neoplasms primitive neuroectodermal tumors and to use descriptive terms to indicate the direction of cellular differentiation, when it has occurred.
Journal ArticleDOI
Intermediate filament proteins in the developing chick spinal cord.
TL;DR: It is suggested that the fibroblast-type IF protein is the only IF protein in the early neuroepithelial cells and that the progeny of these cells will follow one of three different patterns of IF protein expression.
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Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology
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