Showing papers in "International Journal of Immunopharmacology in 1996"

TL;DR: The phytosterols, beta-sitosterol (BSS), and its glucoside (BSSG) enhance the in vitro proliferative response of T-cells stimulated by sub-optimal concentrations of phytohaemagglutinin (PHA) several fold at extremely low concentrations (femtogram level).

TL;DR: Overall in vitro immune function was enhanced by addition of PL into culture of mouse spleen lymphocyte and i.p. injection into mouse, while beta-glucans and other polysaccharides only raised the level of T lymphocyte-mediated immunity.

TL;DR: The in vitro treatment of splenocytes with berberine showed that the anti-SRBC antibody synthesis was influenced in a different manner depending on the time course of its application, and the TEE was most effective in a chronic inflammatory model of adjuvant arthritis.

TL;DR: It is conceivable that cellular interaction between monocytes and endothelial cells is inhibited by fluvastatin, mediated via reducing the expression of adhesion molecules, particularly in the side of monocyte.

TL;DR: Late therapeutic effects of sinomenine in rat arthritic models despite early start of treatment may be related to its antiproliferative effects on synovial fibroblasts in addition to its previously reported anti-inflammatory properties.

TL;DR: Results showed that expression and production of TNFα and TNFβ were inhibited by PTX in a dose-dependent manner and PTX acts on cytokine in a complex manner depending on cellular environment and on the method of activation.

TL;DR: The results indicate that carotenoids such as beta-carotene, canthaxanthin and astaxanth in have possible immunomodulating activities to enhance the proliferation and functions of murine immunocompetent cells.

TL;DR: It appears that AFB1 treatment preferentially affects macrophage functions, and in particular, it decouples the close correlation usually observed between transcriptional and translational controls of IL-1 alpha, IL-6 and TNF production by these cells.

TL;DR: Exposure of T cells to physiological concentrations of STE or nicotine can alter the T cell expression of CD28 and CTLA-4, and the CD4 T cell cytokine expression pattern.

TL;DR: It is demonstrated that the substances extracted from Fu-Ling by 50% hot ethanol significantly augmented the secretion of interleukins IL-1 beta and IL-6 6 h after in vitro cultivation of human peripheral blood monocytes.

TL;DR: Binding of LNT to human monocytes may initiate the influence of this compound on the immune system and differ between individuals.

TL;DR: The data that follow review part of the existing evidence concerning the neuroimmune functions mediated by opioid peptides, with particular regard to dual immunomodulatory effects.

TL;DR: The results suggest that the use of THC can reduce NO.

TL;DR: It is demonstrated that chronic in vivo antalgic therapy of cancer patients with morphine reduced the endogenous cytotoxic activity of natural killer cells, while increasing the development of lymphokine activated killer (LAK) cell cytotoxicity.

TL;DR: The effect of lentinan, a glucan type immunomodulatory polysaccharide was studied on the antitumor cytotoxicity and on the TNF secretion of peritoneal macrophages in inbred H-2 congeneic mouse strains under in vivo and in vitro conditions.

TL;DR: It is demonstrated that O2 is a critical parameter for the in vitro culture of lymphocytes, and suggests that varying pO2 may differentially alter PBMC functionality.

TL;DR: It is observed that subcutaneous injections of 1 mg/animal of CARN 750 had equal or greater stimulatory activity for white blood cell counts and spleen cellularity as well as on the absolute numbers of neutrophils, lymphocytes, monocytes and platelets than did higher or lower doses ofCARN 750 or an optimal dose of granulocyte-colony stimulating factor (G-CSF).

TL;DR: Interleukin-6 suppressed DF proliferation, and, in the presence of sIL-6R, dose-dependently showed much stronger suppressive effects onDF proliferation, suggesting that the IL-6-sIL- 6R complex may have potential as a useful agent for the treatment of SS.

TL;DR: The effectiveness of this new chemoimmunotherapy protocol was seen in the longterm survival of a high percentage of animals and was statistically significant when compared to treatment with single agents in conjunction with chemotherapy or to chemotherapy alone.

TL;DR: Analysis of the mechanism of THC's effects on tumor necrosis factor alpha (TNF-alpha), a major macrophage-produced cytokine and an important mediator involved in cytokine networks and in host defense mechanisms, suggests that TNF- alpha production by macrophages was altered greatly by exposure to THC at the levels of TNF -alpha precursor maturation and secretion.

TL;DR: Should the same phenomenon occur with RTA-based immunotoxins (ITs) in vivo, this might shed light on the development of dgRTA-mediated vascular leak syndrome (VLS) during IT therapy and provide new insights into how to decrease this toxicity in patients.

TL;DR: Beneficial clinical outcomes could be anticipated from cimetidine treatment in patients with Gastric cancer by anti-proliferating effects against gastric cancer cells by specific interactions at the H2-receptor.

TL;DR: It is suggested that beta-agonists, at low concentrations, predominantly inhibit IL-4 production and may therefore act as anti-inflammatory drugs in allergic asthma.

TL;DR: An origin for some of the normal tissue toxicities observed with clinical trials of doubly blocked ricin conjugates is suggested and modification of at least three RTB subdomains will be necessary in genetically engineered ricin fusion proteins.

TL;DR: The results indicate that PMNs are an important source of IL-6 in acute inflammatory reactions, and that the anti-inflammatory actions of dexamethasone is attributable in part to inhibition ofIL-6 production by these cells.

TL;DR: The data indicate that the maximal increase in the induction of MT by a combination of IL-6 and Dex depends on an adequate liver Zn content, and suggests that the synergistic reaction may be important for an enhancement of the radical scavenging ability of tissues in acute phase responses.

TL;DR: Compared for the first time the effects of morphine and methadone on NK cell activity in various organs: in addition to spleen, also in the peritoneal cavity, and lungs, demonstrate the potential adverse effects of these opiates on an important antiviral defence mechanism.

TL;DR: It is demonstrated that phosphorothioate oligodeoxynucleotides can selectively inhibit IL-1r expression leading to a reduction inIL-1 dependent gene expression.

TL;DR: It is suggested that combination therapy with safe muramyl peptides and IFN-α/β could constitute a highly effective and new regimen for the treatment of viral infections in humans.

TL;DR: The presence of anti-nocardia antibodies in human sera and their production by both stimulated and non-stimulated lymphocytes points to the natural sensitization of humans either by ubiquitous no-cardial components or by cross-reactive bacterial or food antigens.