Showing papers in "Journal of Allergy in 1966"

TL;DR: Results indicated that the skin-sensitizing antibody was associated with neither γG- nor γA-globulin but with a unique protein having light chain(s) of immunoglobulins, and found that 0.001 to 0.002 μg N of this protein was sufficient for the passive sensitization of normal human skin for positive P-K reactions.

TL;DR: Significant correlations between the respiratory thresholds and some of the lung functions suggest that asthmatic patients with advanced obstructive change in the lung tend to show bronchoconstriction by inhaled acetylcholine or histamine more readily.

TL;DR: Findings suggest that both the blocking activity and reaginic activity are associated with the same protein other than γA-globulin, as indicated by the results of fractionated sera from ragweed-sensitive patients.

TL;DR: Reports that an accumulation of eosinophils occurs approximately 24 hours after the application, in pollens-sensitive patients, of pollen extract to the superficially denuded skin were confirmed.

TL;DR: Individual cells may be sensitive to more than one antigen but they may not be equally sensitive to all of the antigens with which they react.

TL;DR: Results indicate that C. albicans hypersensitivity is a factor of importance in some patients with severe asthma, and the mechanism of response differs from that to E. coli endotoxin.

TL;DR: A very strong correlation was found between the persistence of wheezing and (a) family history of allergy and (b) presence of other allergies in the patients, and between increased number of eosinophils in the nasal secretions.

TL;DR: It is indicated that the reaginic antibody is associated with none of the known four immunoglobulins, i.e., γG-, γM, γA-, and γD-globulin, and suggest the presence of a fifth immunoglOBulin as a carrier of reganic activity.

TL;DR: The bronchoconstricting effect of histamine and Mecholyl cannot be used to differentiate persons with asthma from those with other types of obstructive pulmonary disease and that the bronchconstricting response may represent a non-specific phenomenon related to many diverse factors.

TL;DR: The results are similar to those obtained using an aerosolized protein antigen and suggest that the intranasal route of immunization is sufficient for sensitization of atopic as opposed to normal individuals.

TL;DR: Patients suffering from asthma had much greater sensitivity to inhaled Mecholyl than did hay fever patients and nonatopic subjects and the range of sensitivity of asthma patients extended from 2 to 68 mcg.

TL;DR: In vitro reaction system, based on the release of histamine from isolated leukocytes of allergic donors, has been used to assay the allergenic activity of ragweed pollen antigens, with Antigen E was the most potent allergen in tests with leukocyte suspensions of different individuals.

TL;DR: The response of the asthmatic subjects included in the study was similar to that which would be expected in persons without bronchial obstruction, and it is likely that such patients would benefit from physical conditioning.

TL;DR: No single immunoglobulin pattern was found to be associated with any specific disease state, but in the primary group there were, generally, very low levels in all immunoglOBulin fractions.

TL;DR: Human peripheral lymphocytes of 27 timothy-sensitive individuals were cultured for ten days in the presence of 15 μg protein nitrogen per milliliter of timothy pollen antigen and transformation to blastlike cells occurred.

TL;DR: The evidence presented here indicates that 300 mg.

TL;DR: An instrument which measures the effective cross-sectional area of the nasal airway, which extends from the upper lip to the forehead and across the cheeks laterally and can be measured with existing equipment.

TL;DR: Allergy questionnaires were given to 1,000 consecutive patients in a large medical clinic and found that patients with seasonal allergy had no colds in a year compared to 32 per cent of the nonallergic patients.

TL;DR: It is suggested that positive skin tests to green algae are immunologically significant and that these organisms may be etiological agents in human respiratory allergies.

TL;DR: There is a difference of interval between the appearance of the peak of eosinophils and that of mast cells in nasal secretions after allergen provocation, which suggests food allergy.

TL;DR: A survey of airborne fungi in the Phoenix metropolitan area, utilizing the culture-plate technique, has been conducted for a one-year period, and the use of special media containing cycloheximide failed to result in the isolation from the atmosphere of spores of Coccidioides immitis, a pathogenic fungus endemic to this area.

TL;DR: Premedication with an antihistaminic drug does not appear to be the complete answer to the prevention of reactions following injection of contrast medium for cholangiography, but it is recommended its use for lessening these reactions.

TL;DR: The model of human hypersensitivity using nonhuman primates passively sensitized by human allergic sera was investigated to evaluate certain physiologic, electrocardiographic, routine light and electron microscopic changes, and immunologic alterations.

TL;DR: The effect of the nasal steroid spray appears to depend, therefore, upon local application in the nose, and that of the oral dose of steroid with equivalent metabolic effect is due to systemic absorption.

TL;DR: Using a quantitative measurement of nasal air flow resistance, nasal obstruction has been objectively demonstrated in response to body surface chilling, with recumbency, and following transient interruption of nasal ventilation.

TL;DR: Analysis of the responses revealed that the changes were not statistically significant and, therefore, under the conditions of this study, it could not demonstrate benefit from 6-mercaptopurine.

TL;DR: A review of 100 patients with respiratory allergy treated an average of 11 years with some but not all the antigens to which they reacted showed marked specific decreases, greater with treatment near the limit of tolerance of the individual patient than with less intensive treatment.

TL;DR: In this paper, extracts of whole body and of venom sac of yellow jackets (Vespula pennsylvanicus) were fractionated by DEAE-cellulose chromatography, and the antigenic heterogeneity of each fraction was analyzed by appropriate rabbit antisera to yellow jacket extracts.

TL;DR: Results together with previous studies show that the coffee-specific allergenicity (antigenicity) present in some samples of chlorogenic acid is due entirely to protein present as a contaminant.

TL;DR: The penetrant-carrier capacity of dimethylsulfoxide through intact human skin was studied with allergens of varying molecular sizes and compositions and results showed that only with DMSO 90 per cent and penicillin could positive Prausnitz-Kustner (P-K) reactions be produced.