Showing papers in "Journal of Investigative Dermatology in 1971"

TL;DR: It appears that the previously postulated end organ sensitivity, thought to account in, part for the occurrence and distribution of acne, may indeed exist and may be mediated by differential rats of conversion of testosterone to dihydrotestosterone in the skin.

TL;DR: The finding that the free fatty acids (FFA) in scalp lipids were proportional to the level of C. acnes suggests that these organisms are the chief source of lipolytic enzymes.

TL;DR: The mechanical parameters, work of fracture, ultimate breaking strength and elongation at fracture, were determined from the stress-strain characteristics of normal human stratum corneum conditioned in various physicochemical environments to be highly dependent on the conditioning relative humidity (RH) and solvent extraction history.

TL;DR: The formation of columns of cells in the horny layer has been confirmed using a new fluorescent staining technique and probably reflects the marginal band, which can otherwise only be seen in the electron microscope.

TL;DR: A procedure to extract and to purify acid-soluble collagen from rabbit skin and a technique to prepare a semi-transparent collagen gel to support growth of postembryonic rabbit, mouse, and human skin epithelial cells are presented.

TL;DR: Evaluation of IF studies, together with the clinical picture, histology, and response to sulfapyridine, points to the importance of immunopathology in the differentiation between dh and bp.

TL;DR: Truly tight junctions (zonulae occludentes or the distal junctions of the stratum granulosum ) were found to be responsible for this occlusion.

TL;DR: It should be possible to develop a rapid biochemical chalone assay, to determine the chemical properties of chalone, to study its mechanism of action, and to examine its possible relevancy to the diseases of epidermal differentiation.

TL;DR: In this article, the transepidermal water loss (TEWL) was measured after complete inhibition of sweating in 17 subjects and skin temperature changes ranging from 25°-39° C were obtained.

TL;DR: Two cell-bound keratinases, II and III, of Trichophyton mentagrophytes were extracted from mycelium and purified and showed that they were not identical to each other nor to extracellular keratinase I of the same species.

TL;DR: The results emphasize that partition coefficient, in addition to pK, is important in determining the rate of excretion of drugs via the human eccrine gland, and excretion appears to be maximal with basic drugs having high partition coefficients and pK 0 values close to the value of sweat pH so that ionization is maximal in sweat and minimal in plasma.

TL;DR: Hemolysis of red blood cells in the presence of some photosensitizing compounds is interpreted to be phototoxic, presumably to the cell membrane, because the RBC is essentially devoid to organelles and the reaction rate increased as the concentration of the photosensitizer increased.

TL;DR: In vitro release profiles were obtained for eight topical creams containing 0.05% (W/W) fluocinonide, a new topical corticoid, and a rank order correlation was obtained between release, percent drug solubilized, and vasoconstrictor response for the creams.

TL;DR: Histopathologically the lesion was a toxic dermatitis with epidermal necrosis, edema, hemorrhange and thrombosis, which may be described as toxic pyoderma.

TL;DR: A detailed sequential study of the early phases of primary irritant and allergic contact dermatitis by means of both light and electron microscopy was undertaken in a search for possible differences not previously appreciated.

TL;DR: A comparison of pigmented and unpigmented tissues revealed a quantitative difference in the distribution of the basal dendritic cells, which did not vary with the degree of pigmentation.

TL;DR: The incidence of basal layer melanocytes has been assessed in the epidermis overlying and adjacent to melanocytic and other tumors of and in the skin and the relationship of clinical 'lentigo' to histologically assessed melanocyte patterns is considered.

TL;DR: The immunochemical requirement of the molecular structure of these compounds appeared to be the presence of a carbon-carbon double bond conjugated with the lactone group as discussed by the authors, which is known to be reactive with cysteine.

TL;DR: Nail biopsies were performed at specific time intervals following the intradermal injection of thymidine-methyl-H 3 and glycine-2-H3 into the toes of human volunteers to examine the appearance of labeled cells in the nail bed at one and two week intervals.

TL;DR: Observations suggest that the factors responsible for the absence of mitosis in cells from the upper epidermal layers are related to irreversible changes in the cell itself rather than to in situ environmental influence.

TL;DR: Investigation of the nature of the dermal influence on epidermal maintenance in recombinants of trypsin-separated human epidermis and dermis grown on the chorioallantoic membrane found it to be relatively heat stable although it could be abolished by more severe heating.

TL;DR: Electron microscopic examination of the proximal matrix of the human toenail revealed that the proximate end was branched into a few to several rootlets and was composed of essentially the same dorsal, apical and ventral portions in which active melanocytes, Langerhans' cells and a Merkel cell were found.

TL;DR: It is assumed that in the compound melanosome, the melanosomes can be degraded by lysosomes at the protein moiety but not at the melanin moiety, as Melanin appears to be very resistant toLysosomal digestion in vitro.

TL;DR: Tyrosinase thus isolated showed only a single activity in both the electrophoresis of a polyacrylamide gel and a cellulose acetate, which is the same as those of the original melanosome and the smooth-surfaced-membrane.

TL;DR: Gel filtraton and dialysis experiments demonstrate that tetracycline binds to C. acnes lipase and even more to bovine serum albumin.

TL;DR: Transfusion of human pemphigus plasma into four monkeys failed to produce disease or lesions in spite of strong binding of antibody to the epidermal intercellular space, casting doubt on the direct role of pemPHigus antibodies in the pathogenesis of this disease.

TL;DR: The amino acid composition and several biophysical properties of human skin lysozyme were found to be very similar to those of human milk and leucocyte lysozymes.