Differential Rates of Conversion of Testerone to Dihydrotestosterone In Acne and in Normal Human Skin- a Possible Pathogenic Factor in Acne
Gail Sansone,Ronald M. Reisner +1 more
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TLDR
It appears that the previously postulated end organ sensitivity, thought to account in, part for the occurrence and distribution of acne, may indeed exist and may be mediated by differential rats of conversion of testosterone to dihydrotestosterone in the skin.About:
This article is published in Journal of Investigative Dermatology.The article was published on 1971-05-01 and is currently open access. It has received 273 citations till now. The article focuses on the topics: Acne & Dihydrotestosterone.read more
Citations
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Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.
Anice E. Thigpen,Richard I. Silver,Joseph M. Guileyardo,M L Casey,John D. McConnell,David W. Russell +5 more
TL;DR: Results are consistent with 5 alpha-reductase type 1 being responsible for virilization in type 2-deficient subjects during puberty, and suggest that the type 2 isozyme may be an initiating factor in development of male pattern baldness.
Journal ArticleDOI
Role of Hormones in Pilosebaceous Unit Development
TL;DR: The biological and endocrinological basis of PSU development and the hormonal treatment of the PSU disorders hirsutism, acne vulgaris, and pattern alopecia are reviewed.
Journal ArticleDOI
Male pseudohermaphroditism due to steroid 5α-reductase deficiency
TL;DR: The data support the thesis that the defect in these male pseudohermaphrodites is secondary to decreased steroid Δ 4 -5α-reductase activity and demonstrates an inherited disorder of steroid metabolism in which the basic enzyme deficiency resides in the target tissues.
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Activity of the Type 1 5α-Reductase Exhibits Regional Differences in Isolated Sebaceous Glands and Whole Skin
TL;DR: In the skin from older patients without acne the type 1 isozyme of 5 alpha-R predominates, its activity is concentrated in sebaceous glands and is significantly higher in seBaceous glands from the face and scalp compared to non-acne-prone areas, and the action of 13-cis retinoic acid in the control of acne is not at the level of 5alpha-R.
References
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Journal ArticleDOI
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
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The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro.
TL;DR: It has been shown that in the presence of a NADPH2-generating system prostatic nuclei convert testosterone to dihydrotestosterone, whereas prostatic cytoplasm reduces dihydotestosterone to androstandiol.
Journal ArticleDOI
A comparative study of the conversion of testosterone to 17-beta-hydroxy-5-alpha-androstan-3-one (Dihydrotestosterone) by prostate and epididymis.
Robert E. Gloyna,Jean D. Wilson +1 more
TL;DR: Dihydrotestosterone formation was measurable in all of the immature prostates studied, including that from calf, and in a variety of other tissues known to be under androgenic control—duck preen gland, the comb and wattle of the chicken, and the preputial gland of rat and mouse.
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The conversion of testosterone to 5 alpha-androstan-17 beta-ol-3-one (dihydrotestosterone) by skin slices of man.
Jean D. Wilson,Joanne D. Walker +1 more
TL;DR: In the patients with testicular feminization dihydrotestosterone formation by slices of skin obtained from the mons was within the normal range, whereas the rates observed in labia majora were lower than the average values obtained in the normal subjects.
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The conversion of testosterone to 5 alpha-androstan-17 beta-ol-3-one (dihydrotestosterone) by skin slices of man.
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