Showing papers in "Journal of Pharmaceutical Analysis in 2022"

TL;DR: In this paper , the direct interactive relationships between BBR and gut microbiota, including regulation of gut microbiota composition and metabolism by BBR, and metabolization of BBR by gut microbiota are discussed.

TL;DR: In this paper , the structure-activity relationship of epimedium flavonoids is described and enzymatic engineering strategies for increasing the productivity of highly active baohuoside I and icaritin are discussed.

TL;DR: In this paper , the authors discuss the current literature on invasive/contact and non-invasive/non-contact technologies (including Wi-Fi, radar, and software-defined radio) that have been effectively used to detect, diagnose, and monitor human activities and COVID-19 related symptoms, such as irregular respiration.

TL;DR: In this article , the authors present an in-depth overview of phytochemicals and discuss their mode of interaction with the NF-κB signaling pathways for controlling the fate of tumor cells for cancer-directed interventions.

TL;DR: In this article , the authors characterize different types of quantum dots, such as silicon, chalcogenide, carbon, and other doped QDs, and summarize the trends in QD-based antibiotic detection.

TL;DR: In this paper , blue-fluorescent carbon quantum dots were synthesized by one-step hydrothermal method from alkali-soluble Poria cocos polysaccharide, which is green source, cheap and easy to obtain, and has no pharmacological activity due to low water solubility.

TL;DR: In this paper , the authors systematically evaluated previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal plants, including phenolic acids, flavonoids, and terpenoids.

TL;DR: In this paper , the authors have discussed that prophylactic phytochemical quercetin supplementation in the form of foods or nutraceuticals may help manage the COVID-19 pandemic.

TL;DR: In this article , the stability of phycocyanin (pH, temperature, and light) is discussed, considering the physicochemical parameters of kinetic modeling, and it remains stable up to 45 °C; however, exposure to relatively high temperatures or acidic pH decreases its half-life and increases the degradation kinetic constant.

TL;DR: A broad outline of current developments in various bioanalytical sample preparation techniques in chromatographic and spectroscopic examinations is provided in this article , with preferred examples of modern trends in bio analytical sample preparation, including sorbent-based microextraction.

TL;DR: A review of the latest findings in strategies and methodologies for quorum sensing screening, involving activity-based screening with bioassays, chemical methods to seek bacterial QS pathways for QS discovery, virtual screening for QSI screening, and other potential tools for interpreting QS signaling, which are innovative routes for future efforts to discover additional QSIs to combat bacterial infections as discussed by the authors .

TL;DR: Wang et al. as mentioned in this paper used fingerprint analysis in combination with chemometrics methods to discover chemical markers for improving the quality control standard of Flos Puerariae (FP), which can be used for further quality control of other traditional Chinese medicines.

TL;DR: In this article , the authors reviewed the current state of knowledge that emphasizes the need to find effective therapeutic agents against COVID-19 by exploiting ACE2 as a potential target, and the increased soluble ACE2 levels and the application of hrsACE2 in patients with CoV-2 can be implemented to control the disease.

TL;DR: In this paper , the authors introduce four multimodal integrated approaches that contribute to the discovery of more comprehensive and accurate Q-markers, thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM.

TL;DR: In this article , the root extract of Rhodiola crenulata (ERC) was used to identify and characterize the key anti-obesity constituents in ERC, as well as to elucidate their anti-hPL mechanisms.

TL;DR: In this article , the authors evaluated the effects of host and habitat on the metabolites in Viscum coloratum through multiple chemical and biological approaches, and concluded that the integration of various chemical and biology approaches combined with multivariate statistical and data fusion analysis, which can determine the influences of host plant and habitat, is a powerful strategy to control the quality of semi-parasitic herbal medicine.

TL;DR: In this paper , a targeted and untargeted profiling of metabolites and elements of human blood serum from 100 bladder cancer patients and the same number of normal controls, with external validation, was attempted using three analytical methods, i.e., nuclear magnetic resonance, gold and silver-109 nanoparticle-based laser desorption/ionization mass spectrometry (LDI-MS), and inductively coupled plasma optical emission spectrometers (ICP-OES).

TL;DR: In this paper , the authors highlight the pharmacological benefits of curcumin and its analogs, flavonoids, and marine peptides in treating human pathologies and provide a perspective on the potential use of these bioactive compounds as molecular templates for the design and development of new radiopharmaceuticals.

TL;DR: In this article , a protocol for pre-formulation studies simulating thermal processing and aging of the printed medicines, tested regarding their morphology and thermal, crystallographic, and spectroscopic profiles, was proposed.

TL;DR: In this paper , the potential utility of erythrocyte metabolite profiles in screening for Alzheimer's disease was determined, based on a preliminary pilot study, where the metabolomes of 10 histopathologically confirmed AD patients and 10 patients without AD (control) were compared.

TL;DR: In this article , an LC-MS/MS method was developed and validated to quantitate sodium oligomannate in different biomatrices, and the plasma pharmacokinetics, tissue distribution, and excretion of SOD in Sprague-Dawley rats and beagle dogs were systematically investigated.

TL;DR: Capillary electrophoresis (CE) is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures, analysis of biomolecules, and characterization of biopharmaceuticals as discussed by the authors .

TL;DR: In this article , a homochiral metal-organic framework (MOF) was used as a chiral coating in open-tubular CEC mode (OT-CEC), and it exhibited high enantioselectivities for several racemic drugs.

TL;DR: Zhang et al. as discussed by the authors showed that 18β-glycyrrhetinic acid (18β-GA) inhibited the expression of α-smooth muscle actin and collagen type I alpha-1.

TL;DR: In this article , a simple one-pot method based on a novel HDES-water two-phase extraction system was constructed for the extraction of weak-polarity bioactive components, anthraquinones, from Rhei Radix et Rhizoma.

TL;DR: In this article , the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody (mAb) therapies was investigated using surface plasmon resonance.

TL;DR: In this article , a review of the potential anticancer activities of DADS and DATS, with emphasis on drug resistance in triple-negative breast cancer (TNBC), is presented, which provides insights into their potential in targeting drug resistance mechanisms of TNBC, especially in clinical studies.

TL;DR: In this paper , a double-shelled hollow sphere (H-C/[email protected]2) was designed and synthesized by simple alcoholic and hydrothermal method, using polystyrene sphere (PS) as a template.

TL;DR: In this paper , an effective strategy was established to systematically characterize the metabolites, deduce the metabolic pathways, and describe the metabolic profiles of bufadienolides isolated from Venenum Bufonis in vivo.

TL;DR: In this paper , a highly sensitive and selective method based on terminal deoxynucleotidyl transferase (TdT) and endonuclease IV (Endo IV) was developed to quantify ALP activity.