Showing papers in "Journal of Steroid Biochemistry in 1983"

TL;DR: Since the SPM prepared from brain tissue is derived from many different neuronal cell types, it is possible that the membrane binding sites for glucocorticoids and for gonadal steroids are present in different neurons.

TL;DR: Scatchard's analysis of [3H]-moxestrol and [ 3H]-estradiol binding proves the existence of a single class of receptor sites having a dissociation constant of 0.18-2.4 X 10(-9) M.

TL;DR: A bidirectional secretion of proteins by Sertoli cells is proposed to explain the presence of specific peptides in the male reproductive tract and blood.

TL;DR: It is concluded that the methods used to prepare and purify rat testis Leydig cells contribute to the apparent Leydigs cell "heterogeneity".

TL;DR: Determination of salivary progesterone concentrations in samples collected by women daily, over extended periods of time, provides a valuable means of assessing ovarian function and may be used to monitor ovulation-induction therapy.

TL;DR: The results imply that the circulating estrogen sulfate could be utilized as the precursor of active estrogen to promote the cell growth in hormone sensitive tumors.

TL;DR: The morphological observations do not support a direct transfer of material from cell to cell, so the observed dependency of germ cells on Sertoli cells and vice versa must be explained by diffusion of substances from one cell to the other.

TL;DR: The studies indicate that the BPH stroma is not only a preferential tissue for 5 alpha-reductase activity and DHT enrichment but also for nuclear estradiol accumulation.

TL;DR: Studies within the Arab population in Israel revealed 25 pseudohermaphrodites due to 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) deficiency, which indicates masculinization in these individuals is a slow process requiring a longer period of time than that of normal puberty to be completed.

TL;DR: When men were transferred from their customary diet to an experimental diet, which contained less fat with a higher polyunsaturated/saturated ratio (P/S-ratio) and more fibre, there was a significant decrease in serum total testosterone concentrations, suggesting that testosterone activity in plasma can at least partly be modified by changing the composition of the diet.

TL;DR: Of the various types of proteins that form noncovalent complexes with steroid hormones, only the serum proteins will be discussed, and characteristics of the binding sites are deduced from specificity studies.

TL;DR: It is concluded that the present results of binding studies with intact MCF-7 cells correlate better with the known hormonal properties of progestagens than those obtained with the cytosol fraction exposed to molybdate at 4 degrees C.

TL;DR: In boars on an artificial light programme the off-season depression during the summer was completely restored and indicates that daylight fluctuations are the main reason for seasonal changes of testicular function in the domestic boar.

TL;DR: The route that free cholesterol follows within the adrenal cortical cell and the physiological factors influencing free cholesterol movement in such cells are important issues to be explored in future.

TL;DR: This survey illustrates the present dispute about the diagnostic confidence and clinical value of the DST in a psychiatric population, and related biochemical aspects.

TL;DR: It was demonstrated that ACTH provokes time-dependent increases in the surface area per cell of smooth endoplasmic reticulum and mitochondrial cristae, which are tightly parallelled by enhancements in the activity per cellOf delta 5-3 beta-hydroxysteroid dehydrogenase and 11 beta-Hydroxylase, respectively.

TL;DR: The resumption of meiosis in mammalian oocytes is associated with sequential changes in follicular steroidogenesis, the principal features of which are an initial stimulation and then suppression of the secretion of oestrogens and androgens, followed by a steady increase in the secretionof progesterone.

TL;DR: Studies of the pharmacokinetics of three contraceptive steroids, ethynyloestradiol, norethisterone and noretha oenanthate, in large groups of women are reviewed and wide variations were observed between women in the various calculated pharmacokinetic parameters.

TL;DR: Physiological studies on the intravenous infusion of pure rhesus SBP, humanSBP, and purified monospecific SBP-antibodies into the rhesUS reveal an inverse relationship between SBP and the metabolic clearance rate of testosterone.

TL;DR: It is concluded that hTeBg, like the androgen binding proteins of the rabbit and rat, is a dimer whose monomer exhibits two protomeric forms that is remarkably homogeneous in its ability to absorb to Concanavalin A-Sepharose.

TL;DR: There were apparent variations in both basal levels of aromatic activity and in response to glucocorticoids in adipose tissue taken from various sites within the body.

TL;DR: The combination of the ram effect and progesterone treatments can provide useful synchrony of oestrus for artificial insemination, and also some gains in fecundity.

TL;DR: Evidence is described suggesting that eosinophil leukocytes mediate a separate group of responses to estrogens independently from genomic activation, and a mechanism is proposed explaining estrogen effects mediated by eos inophils.

TL;DR: A number of fetal tissues may contribute to the formation of deoxycorticosterone, which is present in high concentrations in plasma of the human fetus compared with those in men and nonpregnant women.

TL;DR: Comparison of the binding affinity for ER and antitumor activity of di- and triphenylethylene antiestrogens suggests that this third phenyl ring increases the interaction with ER of the 4-phenolic group of the drugs and/or their aminoethoxy side chain.

TL;DR: Using the high affinity antiestrogens C1628M and trans-hydroxytamoxifen in radiolabeled form, it is found that differences in the interaction of the estradiol receptor complex and antiestrogen receptor complex with DNA cellulose and differences in their association in the nucleus are found.

TL;DR: A series of 4-aza-3-oxosteroids were found to be good inhibitors of steroid 5α-reductase, which has an affinity to the androgen receptor which is orders of magnitude lower than that of 5 α-dihydrotestosterone, spironolactone and cyproterone acetate.

TL;DR: Clinical results indicate that those agents are most effective which not only competitively inhibit androgen binding at the receptor level but also suppress androgen secretion and/or production.

TL;DR: It appears likely that adipose tissue is the site of the increased clearance rates and metabolism of prehormones to dihydrotestosterone and androstanediol, a delicate balance likely exists between production and clearance of these biologically active hormones.

TL;DR: Evidence of a direct effect of antiestrogen mediated by the RE is presented, and the mechanism of resistance to antiestrogens in RE positive breast cancer cells is discussed.