Showing papers in "Organic Process Research & Development in 2022"

TL;DR: A review of recent progress in photobiocatalysis can be found in this paper , including the regeneration of cofactors, generation of H2O2 in situ, cascades involving a photobio-catalytic transformation, and photoinduced enzymatic reactions inspired by the photoactive cofactor within the enzyme.

TL;DR: In this article , a photoredox trifluoromethylation of a thiophenol was modified from the original literature report, and the mechanism was investigated to define the key scale-up parameters.

TL;DR: In this article, the use of a photochemical rotor-stator spinning disk (pRS-SDR) was demonstrated for the TiO2-mediated aerobic photodegradation of aqueous methylene blue.

TL;DR: In this article , the authors report a workflow describing the key reaction parameters toward the successful scale-up of an organic electrosynthetic method from milligram to kilogram scale.

TL;DR: The trend toward increased reaction complexity through the deployment of multienzyme cascades has also encouraged the development of engineering methods and design principles to improve cascade performance and accelerate their development, including engineering of spatial and temporal compartmentalization of cascades via biocatalyst colocation and immobilization as discussed by the authors .

TL;DR: In this article , a review summarizes chemoenzymatic and biocatalytic methodologies for dynamic kinetic resolution (DKR) that have been developed in the past decade.

TL;DR: A review of the literature on the discovery and characterization of SOI catalytic properties such as activity, substrate scope, and enantioselectivity can be found in this paper .

TL;DR: In this paper , a review provides a summary of recently published developments in the field of nonprecious metal catalysis (NPMC) and highlights the range of synthetic applications captured in published research between July and October 2021.

TL;DR: A scalable continuous flow procedure for three key steps in the synthesis of 2H-indazoles, which were identified as highly potent and selective TLR7 and TLR8 antagonists, is described in this article .

TL;DR: In this paper , a one-pot continuous synthesis of menthols from citral was performed over 5 wt % Ni supported on a mesoporous aluminosilicate catalyst with sepiolite as a binder at 70 °C with a selectivity of 75% to menthol.

TL;DR: In this article , a one-pot continuous synthesis of menthols from citral was performed over 5 wt % Ni supported on a mesoporous aluminosilicate catalyst with sepiolite as a binder at 70 °C with a selectivity of 75% to menthol.

TL;DR: In this paper , the main in-line/online analytical tools that can be integrated into flow reactors for the monitoring of chemical reactions are presented, illustrated by selected published examples from leading research laboratories.

TL;DR: In this article , a multigram-scale procedure for HMF was developed by reacting d-fructose with Purolite CT275DR, an acidic resin, in a dimethyl carbonate (DMC)/tetraethyl ammonium bromide (TEAB) biphasic system.

TL;DR: In this article , a kilogram-scale process for the preparation of a potentially broadly applicable electrophilic trifluoromethylating reagent, (trifluorsyl)(4-nitrophenyl)bis(carbomethoxy)methylide (YlideFluor), was reported.

TL;DR: In this article , an overhead stirring and heating were combined to provide accelerated solid-phase peptide synthesis without using an excess of reagents, which is crucial for accessing a large number of peptides in a short time.

TL;DR: In this paper , the authors provide an overview of currently investigated and applied flow calorimeters in research and development in relation to existing concepts and present novel approaches for heat flux measurements as well as integrated sensors.

TL;DR: In this article , the authors provide examples of erroneous statements found in SDSs and analyzes their origins, and several measures are also proposed to improve the quality of SDSS.

TL;DR: In this paper , a sustainable second-generation process for GDC-0134 was developed with a particular focus on safety and greenness, while complying with strong specifications to supply pivotal clinical studies.

TL;DR: In this paper , the authors report a HCN-free transfer hydrocyanation of alkenes and alkynes using commercially available aliphatic nitriles as sacrificial HCN donors in combination with a catalytic amount of air-stable and inexpensive NiCl2 as a precatalyst and a cocatalytic Lewis acid.

TL;DR: In this article , the authors proposed a novel Fe(II)/α-ketoglutarate-dependent dioxygenases (αKGDs) to expand the enzymatic repertoire in the oxidation of l-proline.

TL;DR: In this paper , a new continuous-flow process is presented for synthesis of the pharmaceutical intermediate norketamine, which involves the α-bromination of a ketone, an imination/rearrangement sequence with liquid ammonia, and a thermally induced α-iminol rearrangement.