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Dawei Ma
Researcher at Chinese Academy of Sciences
Publications - 492
Citations - 20451
Dawei Ma is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Aryl & Catalysis. The author has an hindex of 68, co-authored 482 publications receiving 18364 citations. Previous affiliations of Dawei Ma include ShanghaiTech University & Academia Sinica.
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Journal ArticleDOI
A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
Michael Boyce,Kevin F. Bryant,Céline Jousse,Kai Long,Heather P. Harding,Donalyn Scheuner,Randal J. Kaufman,Dawei Ma,Donald M. Coen,David Ron,Junying Yuan +10 more
TL;DR: Salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events and suggests that selective chemical inhibitors of eIF2α deph phosphorylation may be useful in diseases involving ER stress or viral infection.
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Copper/amino acid catalyzed cross-couplings of aryl and vinyl halides with nucleophiles.
TL;DR: It is demonstrated that an l-proline or N,N-dimethylglycine ligand can facilitate most typical Ullmann-type reactions, with reactions occurring under relatively mild conditions and using only 2-20 mol % copper catalysts.
Journal ArticleDOI
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
Junli Liu,Hongguang Xia,Minsu Kim,Lihua Xu,Ying Li,Ying Li,Lihong Zhang,Yu Cai,Helin Vakifahmetoglu Norberg,Tao Zhang,Tsuyoshi Furuya,Minzhi Jin,Zhimin Zhu,Huanchen Wang,Jia Yu,Yanxia Li,Yan Hao,Augustine M.K. Choi,Hengming Ke,Dawei Ma,Junying Yuan +20 more
TL;DR: A molecular mechanism involving protein deubiquitination that connects two important tumor suppressors, p53 and Beclin1, and a potent small molecule inhibitor of autophagy as a possible lead compound for developing anticancer drugs is provided.
Journal ArticleDOI
Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles.
Hui Zhang,Qian Cai,Dawei Ma +2 more
TL;DR: Coupling reaction of electron-deficient aryl bromides with imidazole or pyrazole occurs at 60-90 degrees C to provide the corresponding N-aryl products in good to excellent yields and the possible action of amino acids in these coupling reactions is discussed.
Journal ArticleDOI
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
Haitao Yang,Weiqing Xie,Xiaoyu Xue,Xiaoyu Xue,Kailin Yang,Kailin Yang,Jing Ma,Jing Ma,Wenxue Liang,Qi Zhao,Qi Zhao,Zhe Zhou,Zhe Zhou,Duanqing Pei,John Ziebuhr,Rolf Hilgenfeld,Kwok-Yung Yuen,Luet Lok Wong,Guangxia Gao,Guangxia Gao,Saijuan Chen,Zhu Chen,Dawei Ma,Mark Bartlam,Mark Bartlam,Zihe Rao,Zihe Rao +26 more
TL;DR: A structure-assisted optimization program has yielded compounds with fast in vitro inactivation of multiple CoV Mpros, potent antiviral activity, and extremely low cellular toxicity in cell-based assays.