Showing papers in "Peptides in 1984"

TL;DR: Intraventricular injection of NPY was shown to markedly stimulate feeding and drinking during the illuminated period of the light/dark cycle, a time when rats ingest small amounts of food, and to represent one of the most potent stimulators of feeding yet to be described.

TL;DR: HPLC analysis showed that ACE cleaved SP at Phe8-Gly9 and Gly9-Leu10 to release C-terminal tri- and dipeptide (ratio = 4:1) indicating an active site arginine is required for hydrolysis of SP.

TL;DR: Comparison of anatomical distributions of substance P (SP) and substance P receptors in the rat central nervous system was performed and it was indicated that there is no consistent relationship between the amount of SP receptor and density of SP fibers or cell bodies in a given region of the brain.

TL;DR: Visualization of [125I]ANF binding sites in rat brain by an autoradiographic technique demonstrated that these sites are highly localized in areas such as the olfactory bulb, subfornical organ, area postrema and nucleus tractus solitarius.

TL;DR: It was found that PHI- and VIP-like immunoreactivity occurred in the same autonomic neurons in the upper respiratory tract, tongue and salivary glands with associated ganglia in rat, guinea-pig, cat, pig and man.

TL;DR: The widespread, but selective distribution of neurons containing CRF immunoreactivity supports the neuroendocrine role of this peptide and suggests that CRF, similarly to other neuropeptides, may also function as a neuromodulator throughout the central nervous system.

TL;DR: Research on VIP continues at a rapid pace, with insights into its biosynthesis and its neuronal localization, discovery of novel biological actions, new data on its release and binding to specific receptors, and additional evidence for its roles in physiological regulation and in the pathogenesis of disease.

TL;DR: The interactions of pituicytes with the terminals in the neurohypophysis suggests that these astrocytes are also a part of the mechanism of control of hormone release.

TL;DR: The presence of CRF receptors in areas involved in the control of hypothalamic and autonomic nervous system functions is consistent with the major role ofCRF in the integrated response to stress.

TL;DR: Using light microscopic immunocytochemistry, LHRH neurons and their projections in humans, monkeys, ferrets, bats and rats are identified and the significance of these extrahypothalamic projections is unknown, which may function at some of these sites as a neuromodulator.

TL;DR: Results suggest that CGRP in high doses may be centrally active in regulating consummatory behaviors and treated animals rested more, groomed less and ate less.

TL;DR: High pressure liquid chromatographic characterization of irFMRFamide demonstrated that the immunoreactive material in brain, pancreas and duodenum was different from molluscan F MRFamide but it was also distinct from any known neuropeptide.

TL;DR: The results suggest that VIP may participate in the regulation of REM sleep and that it did not protect the animals from the specific REM inhibiting properties of CAP.

TL;DR: Porcine brain contained an active factor that competed with [3H]-phencyclidine (PCP) for binding to rat brain membranes and showed a heterogenous distribution in brain, with highest concentrations found in hippocampus and cortex, likely to be an endogenous ligand for the PCP receptor.

TL;DR: The microvilli of human placenta are rich in enzymes that may regulate passage of peptides at the maternal-fetal interface, indicating that it contains a large amount of sialic acid.

TL;DR: CGRP was considerably less potent in its effect on gastric acid than calcitonin, a well known central inhibitor of gastric Acid secretion in the rat, and this study suggests that CGRP may be a factor in the central regulation of Gastric acid secretion inThe rat.

TL;DR: The presence of both VIP- and PHI-immunoreactivities in the same ganglion cell supports the recent reports of the isolation and characterisation, using genetic technology, of their common precursor molecule.

TL;DR: Under physiological conditions VIP which is released from its neuronal and non-neuronal cutaneous pools may have an impact on thermoregulation by influencing blood flow and sweat production and it may also modulate axon-endings in Merkel cell-axon complexes and hair follicle receptors.

TL;DR: Data from the present study are compatible with the suggestion that AVP receptors on pituitary corticotrope cells are neither classical V1- nor V2-receptors.

TL;DR: The idea that the 11–13 amino acid sequence is important to the effect of the parent molecule was tested by giving lysine-proline-valine both centrally and peripherally to rabbits made febrile by IV administration of leukocytic pyrogen.

TL;DR: The present findings support a neurotransmitter role for a FMRFamide like peptide in the mammalian brain, possibly related to endocrine and autonomic regulation as well as pain modulation.

TL;DR: This demonstration of a glucagonotrophic action of the neurohypophysial hormones in the in situ perfusion of the rat pancreas confirms earlier studies using isolated islets and bolus IV injection.

TL;DR: A dual origin for VIP in the spinal cord is suggested: Extrinsic, from dorsal root afferent fibres since immunoreactivity was decreased in dorsally rhizotomized animals (cats and rats) and in capsaicin pretreated rats (microinjection of dorsal root ganglia).

TL;DR: Findings are consistent with a hyperactivity of norepinephrine pathways in spontaneously hypertensive rats, leading to a reduced number of cardiac post-junctional secretin/VIP receptors bound to adenylate cyclase.

TL;DR: The correlation of analgesic action with the effects on isolated organs separates the L-Pro 4 -substituted derivatives and D-Phe 3 -CM from the other modified casomorphins and morphine, indicating that the analgesic potency of the former was about ten times that of the latter group in the case of identical GPI-potency.

TL;DR: The notion that VP is a specific non-opioid pain inhibitor is supported, as administration of both arginine VP and 1-deamino-8-D-arginine vasopressin elevated tail flick latencies and systemic pretreatment with dexamethasone potentiated VP analgesia.

TL;DR: Three peaks of immunoreactivity showed ACTH releasing bioactivity in rat pituitary cells cultures, which might be tissue-CRF which may play a role to stimulate ACTH release in the severe stress conditions.

TL;DR: The predominant form present in metastatic tumor tissue was identical to the decapeptide form of canine gastrin-releasing peptide, and bombesin-like immunoreactivity (BLI) was purified by successive applications to reverse phase high pressure liquid chromatography columns.

TL;DR: Fractionation on Sephadex G50 gel of methanol extracts of rat intestine revealed two molecular forms of cholecystokinin of about equal immunopotency: one has an elution volume between CCK33 and CCK12; the other elutes in the salt region as does authentic CCK8.

TL;DR: The finding of elevated levels of VIP in the local circulation after induced penile erection in man and mammals and the ability of VIP to relax the detrusor muscle of the bladder suggests that the peptide may be involved inPenile erection and bladder relaxation, as does the marked VIP depletion in the penis or bladder in patients suffering from diabetic impotence or bladder instability.