R
Richard L. Hauger
Researcher at University of California, San Diego
Publications - 259
Citations - 16870
Richard L. Hauger is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Receptor & Medicine. The author has an hindex of 68, co-authored 228 publications receiving 15813 citations. Previous affiliations of Richard L. Hauger include United States Department of Veterans Affairs & University of Pittsburgh.
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Journal ArticleDOI
Cortisol levels during human aging predict hippocampal atrophy and memory deficits.
Sonia J. Lupien,Mony J. de Leon,Susan De Santi,Antonio Convit,Chaim Tarshish,N. P. V. Nair,Mira Thakur,Bruce S. McEwen,Richard L. Hauger,Michael J. Meaney +9 more
TL;DR: It is demonstrated that aged humans with significant prolonged cortisol elevations showed reduced hippocampal volume and deficits in hippocampus-dependent memory tasks compared to normal-cortisol controls, and the degree of hippocampal atrophy correlated strongly with both the degree and current basal cortisol levels.
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Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans.
TL;DR: It is suggested that working memory is more sensitive than declarative memory to the acute elevations of corticosteroids, which could explain the detrimental effects of cortICosteroids on acquisition and consolidation of information, as reported in the literature.
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The CRF peptide family and their receptors: yet more partners discovered.
TL;DR: The preclinical and clinical development of specific small-molecule antagonists of the CRF1 receptor opens new avenues for the treatment of psychiatric and neurological disorders.
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Genetic variation in human NPY expression affects stress response and emotion
Zhifeng Zhou,Guanshan Zhu,Guanshan Zhu,Ahmad R. Hariri,Mary Anne Enoch,D. Scott,Rajita Sinha,Matti Virkkunen,Deborah C. Mash,Robert H. Lipsky,Xian Zhang Hu,Colin A. Hodgkinson,Ke Xu,Beata Buzas,Qiaoping Yuan,Pei Hong Shen,Robert E. Ferrell,Stephen B. Manuck,Sarah M. Brown,Richard L. Hauger,Christian S. Stohler,Jon Kar Zubieta,David Goldman +22 more
TL;DR: It is shown that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety, consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress.
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Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans.
TL;DR: Sleep stage analyses indicated that the nocturnal increase in IL-6 occurred in association with stage 1-2 sleep and rapid eye movement sleep, but levels during slow wave sleep were not different from those while awake.