Showing papers in "Phosphorus Sulfur and Silicon and The Related Elements in 2000"
TL;DR: In this article, the authors reported the systematic preparation of these salts with variation in both R and especially R' groups, and characterized the 31 P[1H] NMR spectroscopy and elemental analysis.
Abstract: 2,4-Diaryl and 2,4-diferrocenyl-1,3-dithiadiphosphetane disulfide dimmers, (RP(S)S)2, where R = Ph (1a), 4-C6H4OMe (1b) or ferrocenyl (Fc) (1c) react with a variety of alcohols, silanols, or trialkylsilylalcohols to form dithiophosphonic acids in a one-flask procedure. The generated acids have a relatively strong acidity which, upon deprotonation, facilitates the facile high yield conversion to monoanionic salts of the type [S2PR(OR')]−. The present study reports the systematic preparation of these salts with variation in both R and especially R' groups. Compounds were characterized by 31 P[1H] NMR spectroscopy and elemental analysis. High quality single crystals of (1a) were obtained from the slow cooling of a viscous melt which allowed for the X-ray crystal structure to be determined. Qualitative solubility data have been obtained for several of the isolated salts to provide valuable information for synthesis design, especially with regard to metal complexation. The title salts are effective pr...
74 citations
TL;DR: In this paper, a diverse series of phosphonate esters have been prepared using a domestic microwave oven and the microwave enhanced Michaelis-Arbuzov reaction shows remarkable rate acceleration under microwave irradiation and allows the facile synthesis, and in certain cases easy workup, of alkyl, α-substituted and aryl phosphonates.
Abstract: A diverse series of phosphonate esters have been prepared using a domestic microwave oven. The microwave enhanced Michaelis-Arbuzov reaction shows remarkable rate acceleration under microwave irradiation and allows the facile synthesis, and in certain cases easy workup, of alkyl, α-substituted and aryl phosphonates.
61 citations
TL;DR: In this paper, the pyridothienopyridines were treated with carbon disulfide in dioxan solution to give 5a-c. Diazotization of the ortho-aminonitrile 3d gave the triazine derivatives 6a,c.
Abstract: Thienopyridines 3a-c were acetylated with Ac2O to afford the pyridothienopyrimidines 4a-c. Also 3a-c were treated with carbon disulfide in dioxan solution to give 5a-c. Diazotization of 3a-c gave the triazine derivatives 6a-c. Treatment of 3a-c with triethyl orthoformate in acetic acid gave 7a-c in good yield. Chlorination of 7a by POCl3, afforded the chlorine derivatives 8. Similarly diazotization of the ortho-aminohydrazide 3d give the corresponding azide 9 which was subjected to Curtius rearrangement in boiling xylene to give the imidazothienopyridine 10. Compound 12 was obtained by the reaction of 3d with either formic acid or trimethyl orthoformate. Compond 14 was also obtained by the reaction of 3d with ethyl chloroformate. Refluxing of 3d with methyl isothiocyanate gave 15. The interaction of 3d with acetylacetone furnished the pyrazolyl derivative 16. The ortho-aminonitrile 3e reacts with mixture of formic acid and formamide (1:1) to give 7a. whereas 3e reacts with formamide alone give 17...
36 citations
TL;DR: In this paper, the reaction of hydrazines and hydroxylamine with β, β-bifunctionalized phosphonates 1 and 1′ leads to phosphoaminopyrazoles and isoxazoles 2 3, 4 and 5.
Abstract: Reaction of hydrazines and hydroxylamine with β, β-bifunctionalized phosphonates 1 and 1′ leads to phosphoaminopyrazoles and isoxazoles 2 3, 4 and 5. The structure of all obtained products was confirmed by NMR and IR spectroscopy.
34 citations
TL;DR: The pyrazolopyridine derivatives 1a,b reacted with phenylisothiocyanate (2), nitrous acid and cinnamonitrile derivatives 5,b to afford the corresponded pyrazolo[3,4-b]-pyridinyl-3-phenylthiourea derivatives 3a, b,c,b, 3-diazotized aminopyrazolo [3, 4)-pyridine derivative 4a,c and Schiff bases 7a-d in a respective manner as mentioned in this paper.
Abstract: The pyrazolopyridine derivatives 1a,b reacted with phenylisothiocyanate (2), nitrous acid and cinnamonitrile derivatives 5a,b to afford the corresponded pyrazolo[3,4-b]-pyridinyl-3-phenylthiourea derivatives 3a,b, 3-diazotized aminopyrazolo[3,4-b]-pyridine derivatives 4a,b and Schiff bases 7a-d in a respective manner. Compounds 3a,b, 4a,b and 7a,d were taken as the starting materials for the present study owing to the presence of more than one active site. Compounds 3a,b reacted with the halogen-containing reagents e.g. 11a,b, 13 and 15 to give the corresponded thiazole derivatives 12a-d, 14a,b and 16a,b respectively. Compounds 4a,b coupled with the active hydrogen-containing reagents 17a,j to afford the corresponding 3-hydrazino derivatives 18a-t which could be cyclized to give the corresponding triazines 19a-t respectively. Compounds 7a-d reacted with thioglycolic acid (9) to give the corresponding thiazole derivative 10a-d in a good yield. The assigned structures of the newly synthesized compo...
34 citations
TL;DR: Although diverse phosphorus-containing heterocycles had been synthe-sized during the late nineteenth century already, work was still sparse in this area as recently as 1950[1,2] and the realization, around 1950, of the importance of phosphoruscontaining substances in biological processes resulted in intense activity in preparative organophosphorus chemistry, and in an upsurge of research on structural and mechanistic problems as discussed by the authors.
Abstract: Although diverse phosphorus-containing heterocycles had been synthe-sized during the late nineteenth century already, work was still sparse in this area as recently as 1950[1,2]. The realization, around 1950, of the importance of phosphorus-containing substances in biological processes resulted in intense activity in preparative organophosphorus chemistry, and in an upsurge of research on structural and mechanistic problems [3–6].
30 citations
TL;DR: Weakly bonding interactions are a subject of interest for many areas of chemistry as mentioned in this paper, and these interatomic forces are central in the association processes that lead to molecular recognition, self-assembly of supramolecular structures, crystal packing and crystal growth.
Abstract: Weakly bonding interactions are a subject of interest for many areas of chemistry. For example, these interatomic forces are central in the association processes that lead to molecular recognition, self-assembly of supramolecular structures, crystal packing and crystal growth. The activity of biological macromolecules is determined by the structures they adopt as a result of such forces and the interaction with their substrates. The useful macroscopic properties (electric, optical or magnetic) of some materials depend on organization at a molecular level and electronic communication between neighboring molecules.
29 citations
TL;DR: In this paper, a variety of new pyrido[2,1-b]benzothiazole and benzothiazoles, have been prepared via the reaction of 2-substituted methylthiazole with α,β-unsaturated nitriles and activated methylene compounds.
Abstract: A variety of new pyrido[2,1-b]benzothiazole and benzothiazoles, have been prepared via the reaction of 2-substituted methylthiazole with α,β-unsaturated nitriles and activated methylene compounds. The structures of the reaction products were established based on the elemental analyses and spectral data (IR, 1H-, 13C-NMR, MS).
29 citations
TL;DR: Three derivatives of 2-chloro-5,8,9,13b-tetrahydro-5-methyl-6H-Isoquino[2,1 -GI[1,3,2]benzodiazaphosphorine 6-oxides as well as its sulphides were synthesized with the aim of evaluating their antitumor properties.
Abstract: Three derivatives of 2-chloro-5,8,9,13b-tetrahydro-5-methyl-6H-Isoquino[2,1 -GI[1,3,2]benzodiazaphosphorine 6-oxides as well as its sulphides were synthesized with the aim of evaluating their antitumor properties. Three of the twenty one compounds were found to be significantly active (inhibition of tumor growth > 80%) in the Ehrlich ascites carcinoma screen. Several structure-activity relationships were indicated for antitumor activity in this screen. An aziridinyl substituted derivative, bis-(2-chloroethyl)amino substitution (3) also exhibited significant activity against the growth of P-388 lymphocytic Leukemia cells in male BDF, mice (% T/C = 147; % T/C > 125 is considered significant). The reference for activity comparison is cyclophosphamide or cytoxan i.e. [bis(2-chloroethyl)aino]-5,6-dihydro-2H-1,3,2-oxazaphosphorinane 2-oxide [having TIC × 100 = 339 at a dose of 65 mg/kg]
26 citations
TL;DR: In this article, N-phthaloylglycyl chloride was shown to react with trimethylamine in the presence of piperidine and hydrazine to give Schiff bases for 4-nitro-4-aminodiphenylselenide.
Abstract: 4′-Nitro-4-aminodiphenylselenide (1) reacts with chloroacetyl chloride giving 4′-nitro-4-chloroacetylaminodiphenylselenide (2) which undergo facile reaction with certain amines and hydrazine yielding 4′-glycylamino and hydrazinoacetylamino-4′-nitrodiphenylse lenides (3) and (5). Two moles of (2) react with one mole of piperazine and/or hydrazine to give 1,4-bis [p-N-(p′-nitro-diphenylselenido)aminocarbonylmethylene] piperazine (4) and 1,2-bis[p-N-(p′-nitro-diphenylselenido)aminocarbonyl-methylene]hydrazine (6). Condensation of (5) with aromatic aldehydes in the presence of glacial acetic acid yielded new Schiff bases (7). N-phthaloylglycyl chloride reacts with (1) in dioxane in the presence of trimethylamine to give N-(N′-phthaloylaminoacyl)-4-aminodiphenylselenide (8), hydrazinolyses of which affords N-(aminoacyl)-4-amino-4′-nitrodiphenylselenide (9). Compound (9) undergoes facile condensation with aromatic aldehydes in the presence of piperidine to give Schiff bases (10). Compound (2) interacts...
25 citations
TL;DR: In this paper, a quaternary ammonium hydroxide ion exchange resin is used as a base to promote the addition of diethyl phosphite to aryl aldehydes for a Pudikov type reaction.
Abstract: A mild, efficient synthesis of α-hydroxy phosphonates is described where a quaternary ammonium hydroxide ion exchange resin is used as a base to promote the addition of diethyl phosphite to aryl aldehydes for a Pudikov type reaction.
TL;DR: In this article, the authors conducted an anti-inflammatory activity screening for IIa, b, In, IV, VIb and VIIIa - I was carried out at 100 mg/kg p.o.
Abstract: 9- Chloro - 2(substituted) - acridines (I) on condensation with 4 - amino antipyrine, I-amino anthraquinone and 2 - amino anthraquinone gave corresponding condensed products II, III and IV. Phenyl isothiocyanate reacts with 9 - amino - 2 or 4 (substituted)-acridines (V) and iminothiazolines (VII) to give corresponding N-phenyl -N′- substituted thioureas VI and VIII in good yield. Anti-inflammatory activity screening for IIa, b, In, IV, VIb and VIIIa - I was carried out at 100 mg/kg p.o. and compounds IV, VIIIa, VIIIb and VIIIg-k showed 12, 12, 14, 18, 7, 23, 13 and 18% activity whereas all others were found to be inactive. Analgesic activity screening for IIb, III and IV was carried out at 100mg/kg p.o. Only compound III showed 25% activity whereas IIb and IV were found to be inactive.
TL;DR: In this paper, 2-hydrazino derivatives were reduced to 2-aminothienopyrimidin-4-one and 2-pyrazolinone derivatives, respectively.
Abstract: Condensation of 5,6-dimethyl-2-hydrazino-3,4-dihydrothieno[2,3-d]pyrimidin-4-one (2) with aromatic aldehydes gave the arylhydrazones 3a-c which cyclized into thienotriazolopyrimidin-5- one 4a-c. Reactions of 2 with aliphatic acids afforded the thienotriazolopyrimidin-5-one 5a.b. Also, reaction of 2 with each of carbon disulfide and nitrous acid afforded 3-mercaptothienotriazolopyrimidin-5-one 7, and tetrazolothienopyrimidin-5-one 8, respectively, the latter compound 8 could be reduced to 2-aminothienopyrimidin-4-one 9. On the other hand, 2-hydrazino derivative 2 condensed with δ-haloketones yielded 3-substituted-thienopyrimidotriazin-6-one 10a.b with new ring system, and with β-diketones, β-ketoesters to form 2- (I-pyrazolyl) derivatives 13a-c, 14. The 2-pyrazolinone derivative 15 condensed with aromatic aldehydes to afford arylidene derivatives 16a-c. Also, reaction of 2 with ethyl cyanoacetate yielded 2-(pyrazolyl) derivatives 17.
TL;DR: A group of (carbamoylaminophenoxymethyl)-dimethylphosphine oxides and corresponding thiocarbarnoyl derivatives 14−26 were prepared via reaction of 2-, 3, and 4-(dimeth-ylphosphinylmethoxy)-phenylamines with isocyanates and isothiocyanate resp., The composition of the new compounds was confirmed by elemental analysis, IR, 1H and 31P{1HJ} MNR spectroscopy as discussed by the authors.
Abstract: A group of (carbamoylaminophenoxymethyl)-dimethylphosphine oxides 1–13 and corresponding thiocarbarnoyl derivatives 14–26 were prepared via reaction of 2-, 3-and 4-(dimeth-ylphosphinylmethoxy)-phenylamines with isocyanates and isothiocyanates resp., The composition of the new compounds was confirmed by elemental analysis, IR, 1H and 31P{1HJ} MNR spectroscopy.
TL;DR: In this article, coumarin-3-thiocarboxamide was reacted with malononitrile, cyanoacetamide or cyanothioacetamide to give the corresponding thiopyrano(3,4-c)coumarin 1-carbonitrile 2.
Abstract: Coumarin-3-thiocarboxamide 1 was reacted with malononitrile, cyanoacetamide or cyanothioacetamide to give the corresponding thiopyrano(3,4-c)coumarin-1-carbonitrile 2. Also, compound 1 was reacted with a variety of active methylenes having an δ-cyano or δ-keto group to give thiopyranocoumarin derivatives 3–9. The reaction of compound 1 with different ketene N.S-acetals, afforded the corresponding thiazino(5,4-c)coumarin derivatives 10,13 and 16. On reacting compound 10 or 13 with malononitrile, spiro pyran-4,2′-thiazino(5,4-c)coumarin 11 or 14 were obtained, while the reaction of compound 16 with malononitrile gave spiro cyclobutene-1,2′-thiazino(5,4-c)coumarin derivative 17. Treating of compounds 10,13 or 16 with cyclohexylidenemalononitrile afforded spiro naphthyl-1,2′-thiazino(5,4-c) coumarin derivatives 12,15 or 18 respectively. Treatment of compound 1 with CS2 and malononitrile under PTC condition afforded 1,3-dithiano(5,4-c) coumarin derivative 19, which in turn reacted with malononitrile o...
TL;DR: In this article, a β-Phosphonyl-β-chlorovinylaldehyde was synthesized through chloroformylation of the Vilsmeier reagent with acetylphosphonate, and reacted with hydrazine, oxyammonia, formamidine, and guanidine to give the corresponding phosphonyl heterocyclic compounds.
Abstract: β-Phosphonyl-β-chlorovinylaldehyde was synthesized through chloroformylation of the Vilsmeier reagent with acetylphosphonate, and reacted with hydrazine, oxyammonia, formamidine, and guanidine to give the corresponding phosphonyl heterocyclic compounds.
TL;DR: In this article, C-Benzothiazoloyl-N-arylhydrazonoyl bromides have been shown to react with each of methyl 2-thiazolylcyanomethine carbodithioate (2), alkyl carbidithioates 8-10, and methyl thiocarbamates 14a-c in the presence of triethylamine to give 2,3-dihydro-1,3,4-thiadiazoles in good yields.
Abstract: C-Benzothiazoloyl-N-arylhydrazonoyl bromides 1a,b have been caused to react with each of methyl 2-thiazolylcyanomethinecarbodithioate (2), alkyl carbodithioates 8–10, and methyl thiocarbamates 14a-c in the presence of triethylamine to give 2,3-dihydro-1,3,4-thiadiazoles in good yields. In contrast, hydrazonoyl bromides react with each of phenylthiourea (19a), phenylthiosemicarbazide (19b), and benzoylthiosemicarbazide (19c) afforded 5-arylazothiazole 22–24(a-c) derivatives, respectively. Structures of the new compounds were elucidated on the basis of elemental analyses, spectral data, and alternative methods of synthesis whenever possible.
TL;DR: In this paper, the Thorpe-Ziegler cyclization of 4-Aryl-3-cyano-2-substituted-methyIthiocyclopenta[b]pyridines (3a-c and 4a-i) was used to obtain the corresponding 3-amino-4-aryl-2functionallized-cyclopenta[e]thieno [2,3]-pyridine-2(1H)-thiones(2a-b] pyridine (
Abstract: 4-Aryl-3-cyano-2-substituted-methyIthiocyclopenta[b]pyridines (3a-c and 4a-i) were prepared by reaction of 4-aryl-3-cyanocyclopenta[b]pyridine-2(1H)-thiones(2a-c) with chloroacetonitrile or chloro-N-arylacetamides, respectively. On treatment of these products with sodium ethoxide in boiling ethanol, they underwent intramolecular Thorpe-Ziegler cyclization to afford the corresponding 3-amino-4-aryl-2-functionallized-cyclopenta[e]thieno [2,3-b]pyridines (5a-c and 6a-i). Most of the latter thienopyridines were used as synthons for the target cyclopenta[5′,6′]pyrido[3′,2′:4.5]thieno[3,2-d]pyrimidines and cyclopenta[5′,6′]. pyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]triazines.
TL;DR: In this paper, isocyanates, isothioformarnides, aldehydes, acetylenedicarboxylic acid and anthranilic acids were reacted with oxazolidines pyrroline, quinazolinones and benzothiazoloquinazolinone to produce imidazolidineimino(thiones and dithiones) and imidazoquinoxalines, respectively.
Abstract: Cyanothioformarnides were reacted with isocyanates, isothiocyanates, aldehydes, acetylenedicarboxylic acid and anthranilic acids to produce imidazolidines, oxazolidines pyrroline, quinazolinones and benzothiazoloquinazolinones, respectively. Interaction of imidazolidineimino(thiones and dithiones) with o-phenylenediamines gave rise to imidazoquinoxalines and imidazoquinoxalinethiones, respectively.
TL;DR: S-mono to S,S-tetrasubstituted 1,3-nitrodiene compounds 3,6 have been obtained from the reaction of 2-nitropentahalobutadiene with p-methylthiophenol as mentioned in this paper.
Abstract: S-mono to S,S-tetrasubstituted 1,3-nitrodiene compounds 3–6 have been obtained from the reaction of 2-nitropentahalobutadiene with p-methylthiophenol. Mono(thio)substituted diene compound 3 gives d...
TL;DR: In this paper, a series of new derivatives of 1,2,4-triazole-3-thiol derivatives were described, which were tested for their circulatory activity, but found not pharmacologically active.
Abstract: In the present paper we describe the preparation of series of new derivatives of 1,2,4-triazole-3-thiol. As starting materials methyl 3-acyldxithiocarbazates were used, which on reaction with amines gave the corresponding 4,5-disubstituted 1,2,4-triazole-3-thiol derivatives (3). Into the 4-position of the 1,2,4-triazole-3-thiol system a β-hydroxyethyl substituent was introduced (compounds 4). These compounds were alkylated with methyl iodide to from 6, with N-substituted amides of chloroacetic acid (products 7 and 8), and aminomethylated with formation of Mannich bases (10), Some of the thiols 4 were desulfurized to 9. The new compounds were tested for their circulatory activity, but found not pharmacologically active.
TL;DR: In this article, triazolo[4,5-d]pyrimidine and pyrazolo[3,4-d]-pyridine derivatives of aminomethyl-and aminometricoxymethyl dimethylphosphine oxides 8, 9 and 12 as well as phosphonate 20 showed herbicidal and plant growth regulating activity.
Abstract: New triazolo[4,5-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives of aminomethyl-and aminomethyloxymethyl dimethylphosphine oxides 8–14 as well as of esters of (aminomethane) phosphonic acid 18–20 were synthesized. The structure of the compounds prepared was confirmed by means of elemend analysis, IR, 1H- and 31P(1H)-NMR spectroscopy. Tertiary phosphine oxides 8, 9 and 12 as well as phosphonate 20 showed herbicidal and plant growth regulating activity.
TL;DR: P-ethoxyphenylcyanothioforrnamide (1) was reacted with α,β-unsaturated ketone and N-p-chlorophenylmaleimide (4) to furnish pyrrole and pyrrolo[2,3-c]pyrrol-4,6-diones (3) and (5) respectively as discussed by the authors.
Abstract: P-Ethoxyphenylcyanothioforrnamide (1) was reacted with α,β-unsaturated ketone (2) and N-p-chlorophenylmaleimide (4) to furnish pyrrole and pyrrolo[2,3-c]pyrrol-4,6-diones (3) and (5) respectively. Also, interaction of 1 with anthranilic acid and o-phenylenediarnine produced 3-(4′-ethoxyphenyl)-2-thioxoquinazolin-4-one (6) and 2-thioxobenzirnidazoles (7). When, 1 was reacted with iso(thio)cyanates caused cyclization to afford 5-imino-4-thioxoirn-idazolidinones (9). Compound 9 was subjected to some reagents such as hydrazine hydrate, thiosemicarbazide, o-phenylenediamines, hydrogen sulfide and HCl to give 5-hydrazono, 4-thiosemicarbazono, and thiohydantoin derivatives (10–17), respectively.
TL;DR: In this paper, the structures of newly synthesized heterocyclic compounds were established on the basis of the data of IR, 1H NMR and elemental analyses, and all structures of the newly synthesised compounds were obtained using the data collected from IR, NMR, and elemental analysis.
Abstract: Cyanothioacetamide (1) reacted with α- and β-naphthaldehyde 2a,b to afford the corresponding 3-naphthyl-2-thiocarboxamidopropenonitriles 3a,b. Compounds 3a,b structures could be elucidated via their reactions with acrylonitrile, ethyl acrylate (4a,b). N-arylmaleimides 6a-c and ethyl acetoacetate (8). The isolated products could be represented as the thiopyran, thiopyranopyrrolidine and pyridinethione derivatives 5a-d, 7a-f and 9a,b respectively. Pyridinethiones 9a,b had been used as the starting materials in the present study in addition to the next ones to synthesize several new thienopyridines, pyridothienotriazine and pyridothienopyrimidines 12a-f, 15a,b, 16b, 17–19a,b respectively through their reactions with the corresponding reagents. All structures of the newly synthesized heterocyclic compounds were established on the basis of the data of IR, 1H NMR and elemental analyses.
TL;DR: In this paper, a manipulatively one-pot and rapid method for the synthesis of alkyl p-toluenesulfinate esters from p-Tolueneulfinic acid, supported thionyl chloride on silica gel and aliphatic alcohols in solid phase conditions is described.
Abstract: A manipulatively one-pot and rapid method for the synthesis of alkyl p-toluenesulfinate esters 1 from p-toluenesulfinic acid, supported thionyl chloride on silica gel and aliphatic alcohols in solid phase conditions is described.
TL;DR: In this article, the biological interesting enantiomerically enriched α-aminophosphinic acids and their derivatives were prepared by asymmetric hydrogenation of suitable precursors and saponification of the obtained products.
Abstract: For the first time, the biological interesting enantiomerically enriched α-aminophosphinic acids and their derivatives were prepared by asymmetric hydrogenation of suitable precursors and saponification of the obtained products. Enantiomeric excesses of up to 99 % were obtained.
TL;DR: In this paper, an octahedral geometry for both the metals have been proposed and the newly synthesized compounds have been characterized by molecular weights, IR, 1H and 31P NMR spectral measurements.
Abstract: Complexes of the type Cp2,M[S2POGO[,2 [where Cp = C5H5, M=Ti or Zr; G = -C{CH3)CH2CH(CH3), -CH2C(CH3)2CH2-, -C(CH3)2C(CH3)2 and CH2CH2CH(CH3)-] were prepared by reaction of Cp2MCl2 and NH4[S2POGO] in 1:2 molar ratio in CH2Cl2. These newly synthesized compounds have been characterized by molecular weights, IR, 1H and 31P NMR spectral measurements. An octahedral geometry for both the metals have been proposed.
TL;DR: In this paper, a one-pot synthesis of 4-methylthio-N-aryl-2-pyridones and their deazapurine analogues by the reaction of ketene dithioacetals with substituted acetanilides has been reported.
Abstract: A new one-pot synthesis of 4-methylthio-N-aryl-2-pyridones and their deazapurine analogues by the reaction of ketene dithioacetals with substituted acetanilides have been reported.
TL;DR: In this article, the chemical constituents of sulfur containing the 5-oxo-1,2,4-triazin-3-yl moiety are reviewed and the synthesis is discussed.
Abstract: Studies on the chemical constituents of sulfur containing the 5-oxo-1,2,4-triazin-3-yl moiety are reviewed. The synthesis. unique features of the structures and biological significance of these constituents are discussed.
TL;DR: The Lawesson Reagent (L.R) as discussed by the authors reacts with hydrazonates and hydroxymates to give 1,3,4,2-thiadiazaphospholines 4 and 1, 3,5, 2-oxathiazaphophospholine 5 derivatives.
Abstract: The Lawesson Reagent (L.R) 1 reacts with hydrazonates 2 and hydroxymates 3 to give 1,3,4,2-thiadiazaphospholines 4 and 1,3,5,2-oxathiazaphospholines 5 derivatives. The structure of products 4 and 5 is confirmed by IR and NMR spectroscopy.