Showing papers in "Progress in Growth Factor Research in 1990"

TL;DR: There are also convincing indications that the administration of NGF prevents the atrophy and death of axotomized cholinergic neurons in the adult central nervous system, and improves the performance of rats selected for their poor memory retention in simple behavioral tasks.

TL;DR: Several factors that stimulate the proliferation of endothelial cells in vitro have been shown to induce angiogenesis in vivo, and the differential expression, release and activation of these factors might regulate ang iogenesis under various physiological and pathological conditions.

TL;DR: The findings presented clearly illustrate that a growth factor can elicit different responses depending on the context of its action; the cell type involved, the concentration of the growth factor and the presence or absence of other growth factors can all influence the cellular response both quantitatively and qualitatively.

TL;DR: IL-1ra represents the first naturally-occurring cytokine inhibitor and may be important in modulating IL-1 effects in both normal and abnormal physiology.

TL;DR: Evidence is reviewed that TGF beta 1, beta 2 and beta 3 are involved in several mammalian developmental processes, including control of growth, differentiation, tissue inductions and morphogenesis.

TL;DR: It has been proposed that changes in the nuclear oncogenes, perhaps involving the loss of function of tumour suppressor genes, may allow cells to enter the cell cycle and changes in growth factors, their receptors or intracellular second messenger systems may stimulate unregulated growth.

TL;DR: A detailed examination of the structure/function relationships of the PTKs and their catalytic domains is particularly revealing in trying to establish the roles that these proteins play in signal transduction in eukaryotic cells.

TL;DR: Activin has been shown to be a potential regulator of early development of Xenopus laevis and of general importance to the understanding of the role of the family of growth factors in developmental processes.

TL;DR: This review discusses the numerous growth factor-toxins that have been created and describes some of their applications.

TL;DR: Sensitive and selective bioassays are described for growth factors acting on substrate-attached cells, in particular members of the epidermal growth factor, transforming growth factor β, platelet-derived growthFactor, insulin-like growth factor and heparin-binding growth factor families.

TL;DR: The recent advances in understanding of the negative regulation of primitive haemopoietic cells are described and the possible involvement of inhibitory factors in the development of haemoplastic malignancy is discussed.

TL;DR: Its relatively limited sphere of action--the fetal genital tract--and the fact that it is secreted into the general circulation and can act at long range imply that AMH is more like a hormone than a growth factor, but the complex interaction between hormones and growth factors make a formal distinction impossible.

TL;DR: The range of known purified and cloned growth factors and their target cells within the megakaryocytic lineage is described and Hypotheses about the nature of thrombopoietin, its relationship to known growth factors, especially Interleukin-6 (IL-6), and the specificity of a thromBopoetic response following change in the circulating platelet mass are presented.

TL;DR: Temperature-sensitive IL-2 binding to the high-affinity receptor is consistent with the stepwise binding/affinity conversion model and signal transduction by theIL-2R appears to involve the activation of tyrosine protein kinase.

TL;DR: The sevenless RTK mediates the position-dependent specification of a particular photoreceptor cell type (R7) in the eye and encodes an RTK required for the specification of the terminal regions of the Drosophila larva.