Journal ArticleDOI
Angiogenic growth factors.
TLDR
Several factors that stimulate the proliferation of endothelial cells in vitro have been shown to induce angiogenesis in vivo, and the differential expression, release and activation of these factors might regulate ang iogenesis under various physiological and pathological conditions.About:
This article is published in Progress in Growth Factor Research.The article was published on 1990-01-01. It has received 195 citations till now. The article focuses on the topics: Angiogenesis & Fibroblast growth factor.read more
Citations
More filters
Journal ArticleDOI
Regulation of Wound Healing by Growth Factors and Cytokines
Sabine Werner,Richard Grose +1 more
TL;DR: This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds and reports on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
Journal ArticleDOI
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.
TL;DR: It is shown that expression of an endothelial cell-specific mitogen, vascular endothelial growth factor (VEGF), is induced in astrocytoma cells but is dramatically upregulated in two apparently different subsets of glioblastoma cells, which strongly support the concept that tumour angiogenesis is regulated by paracrine mechanisms and identify VEGF as a potential tumourAngiogenesis factor in vivo.
Journal ArticleDOI
The wound healing process: an overview of the cellular and molecular mechanisms.
TL;DR: Wound classification, the physiology of the wound healing process and the methods used in wound management are discussed.
Journal ArticleDOI
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
TL;DR: The biological relevance of the VEGF/Flk-1 receptor/ligand system for angiogenesis is investigated using a retrovirus encoding a dominant-negative mutant of the Flk- 1/VEGF receptor to infect endothelial target cells in vivo, and tumour growth is prevented in nude mice.
Journal ArticleDOI
Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
TL;DR: The temporal and spatial expression of V EGF is consistent with the hypothesis that VEGF is synthesized and released by the ventricular neuroectoderm and may induce the ingrowth of capillaries from the perineural vascular plexus and with a role of VEGf as a multifunctional regulator of endothelial cell growth and differentiation.
References
More filters
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Anita B. Roberts,Michael B. Sporn,Richard K. Assoian,J M Smith,Nanette S. Roche,Lalage M. Wakefield,U. Heine,Lance A. Liotta,Vincent Falanga,John H. Kehrl +9 more
TL;DR: Further data are obtained to support a role for TGF-beta as an intrinsic mediator of collagen formation: conditioned media obtained from activated human tonsillar T lymphocytes contain greatly elevated levels of T GF-beta compared tomedia obtained from unactivated lymphocytes.
Journal ArticleDOI
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
TL;DR: A growth factor for vascular endothelial cells identified in the media conditioned by bovine pituitary follicular cells and purified to homogeneity by a combination of ammonium sulfate precipitation, heparin-sepharose affinity chromatography and two reversed phase HPLC steps is proposed to be named VGF on the basis of its apparent target cell selectivity.
Journal ArticleDOI
Vascular permeability factor, an endothelial cell mitogen related to PDGF
Pamela Jean Keck,Scott D. Hauser,Gwen G. Krivi,Kim Sanzo,Thomas G. Warren,Joseph Feder,Daniel T. Connolly +6 more
TL;DR: The cDNA sequence of VPF from human U937 cells was shown to code for a 189-amino acid polypeptide that is similar in structure to the B chain of platelet-derived growth factor (PD GF-B) and other PDGF-B-related proteins, suggesting that VPF appears to be related to the PDGF/v-sis family of proteins.
Journal ArticleDOI
Induction of angiogenesis during the transition from hyperplasia to neoplasia
TL;DR: It is reported here that angiogenic activity first appears in a subset of hyperplastic islets before the onset of tumour formation, suggesting that induction of angiogenesis is an important step in carcinogenesis.