Recent Patents on Biomedical Engineering 

About: Recent Patents on Biomedical Engineering is an academic journal. The journal publishes majorly in the area(s): Regeneration (biology) & Cartilage. It has an ISSN identifier of 1874-7647. Over the lifetime, 34 publications have been published receiving 378 citations.

Design and Application of Magnetic-based Theranostic Nanoparticle Systems

Abstract: Recently, magnetic-based theranostic nanoparticle (MBTN) systems have been studied, researched, and applied extensively to detect and treat various diseases including cancer. Theranostic nanoparticles are advantageous in that the diagnosis and treatment of a disease can be performed in a single setting using combinational strategies of targeting, imaging, and/or therapy. Of these theranostic strategies, magnetic-based systems containing magnetic nanoparticles (MNPs) have gained popularity because of their unique ability to be used in magnetic resonance imaging, magnetic targeting, hyperthermia, and controlled drug release. To increase their effectiveness, MNPs have been decorated with a wide variety of materials to improve their biocompatibility, carry therapeutic payloads, encapsulate/bind imaging agents, and provide functional groups for conjugation of biomolecules that provide receptor-mediated targeting of the disease. This review summarizes recent patents involving various polymer coatings, imaging agents, therapeutic agents, targeting mechanisms, and applications along with the major requirements and challenges faced in using MBTN for disease management.

Recent Developments on Citric Acid Derived Biodegradable Elastomers

Abstract: Biodegradable elastomers have recently found widespread application in many areas of biomedical engineering such as tissue engineering, drug delivery, and bioimaging. In particular, the recent developments in research have led to the creation of citric acid based polymers with enhanced mechanical properties, novel design strategies for crosslinking, nanoporous features, and unique photoluminescent capabilities. The present review will cover the recent patents involving citric acid derived biodegradable biomaterials within the field of biomedical engineering including poly (diol citrates) and their composites, crosslinked urethane-doped polyesters (CUPEs), poly (alkylene maleate citrates) (PAMCs), poly (xylitol-co-citrates) (PXC), and aliphatic biodegradable photoluminescent polymers (BPLPs). The synthesis, development, and applications of these novel polymers will be discussed along with the current trends and future developments in the biomaterials field.

Recent Advancements in Preventing Teeth Health Hazard: The Daily Use of Hydroxyapatite Instead of Fluoride

Abstract: Hydroxyapatite (HA) is commonly considered the most promising synthetic biomaterial for biomedical applications in orthopaedic, dental and maxillofacial surgery for its biocompatibility, bioresorption and bioactivity. Only recently a chemical-physical experimental approach has been utilized to investigate the capability of synthetic carbonated hydroxyapatite nanocrystals (CHA) to produce in vivo biomimetic mineral deposition on enamel and dentine surface through a daily use. Demineralised enamel and dentine slabs have been treated in vitro with synthetic biomimetic hydroxyapatite nanocrystals for a few minutes. This induced a surface remineralisation, forming a biomimetic apatite coating on enamel and dentine surface. In fact, enamel remineralisation quickly occurs thanks to the specific chemicalphysical characteristics of innovative nanostructured hydroxyapatite particles which closely resemble mineral enamel constituents. Therefore the experimental results suggest the possibility to perform teeth wear-deterioration prevention. Carbonated hydroxyapatite nanocrystals synthesized with tailored biomimetic characteristics for composition, structure, size and morphology can chemically bind themselves on the surfaces of teeth hard tissues, filling the scratches, producing a bound biomimetic apatitic coating, protecting the enamel surface structure. Over the past few decades many products for dental damage prevention (toothpastes, rinses and gels) have been commercialized and patented expressly for the fluoride remineralisation effect. Only recently the numerous applications of hydroxyapatite as bone filler biomaterial for implantation surgery have evidenced innovative and important opportunities for decay prevention through a daily use of oral care products containing hydroxyapatite. The aim of this paper is to review these recent patents and classify them according to their actual possibilities to safeguard

Recent Patents and Advances in the Next-Generation Sequencing Technologies

Abstract: We are now witnessing a new genomic revolution due to the arrival and continued advancements in the next-generation high-throughput sequencing technologies, which encompass sequencing by synthesis including fluorescent in situ sequencing (FISSEQ) and pyrosequencing, sequencing by ligation including using polony amplification and supported oligonucleotide detection (SOLiD), sequencing by hybridization in combination with sequencing-by-ligation and nanopore technology, nanopore sequencing and other novel sequencing technologies using nano-transistor array, scanning tunneling microscopy and nanowire molecule sensors etc. We review here major technologies and recent patents for achieving high-throughput, ultra-fast, extremely cheap, and highly accurate sequencing. We will see enormous impacts of these next-generation sequencing methods for solving complex biological problems and for ushering in the practice of personalized medicine.

Review of Recent Patents on Foldable Ventricular Assist Devices

Abstract: Congestive heart failure accounts for a high morbidity worldwide. The only effective treatment for end-stage patients is heart transplantation or, in light of the shortage of suitable donors, an artificial heart or ventricular assist device (VAD). The newer-generation continuous-flow rotary VADs allow for a significant reduction in size and an improvement in reliability. However, the invasive implantation still limits this technology from being offered to critically ill patients. To benefit more heart failure patients, there is a need to develop a long-term VAD which can be implanted via minimally in-vasive procedure. Recently, expandable/deployable devices have been investigated as a potential solution. Such a device can be inserted percutaneously via the peripheral vessels in its collapsed form and operate in its expanded form at the de-sired location. This paper reviews significant patents on foldable VADs using mechanical and/or material means. Me-chanically folded structures adapt joints and links to facilitate the folding process whilst utilization of elastic materials al-lows the structure to be bent or twisted without permanent deformation. Current and future developments of foldable VADs are discussed. Foldable pumps could generate less blood damage and mechanical wear as compared to current miniature percutaneous VADs. Therefore, foldable VADs have the potential for longer-term application and minimally invasive insertion, providing a promising solution for heart failure patients.