P
Pradeep S. Tanwar
Researcher at University of Newcastle
Publications - 67
Citations - 2552
Pradeep S. Tanwar is an academic researcher from University of Newcastle. The author has contributed to research in topics: Wnt signaling pathway & Cancer. The author has an hindex of 23, co-authored 55 publications receiving 2106 citations. Previous affiliations of Pradeep S. Tanwar include Harvard University & University of New England (Australia).
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Journal ArticleDOI
Lin28 promotes transformation and is associated with advanced human malignancies
Srinivas R. Viswanathan,John T. Powers,William S. Einhorn,Yujin Hoshida,Tony Ng,Sara Toffanin,Maureen J. O'Sullivan,Jun Lu,Letha A. Phillips,Victoria L Lockhart,Samar P. Shah,Pradeep S. Tanwar,Craig H. Mermel,Rameen Beroukhim,Mohammad Azam,José A. Teixeira,Matthew Meyerson,Timothy P. Hughes,Josep M. Llovet,Jerald P. Radich,Charles G. Mullighan,Todd R. Golub,Poul H. Sorensen,George Q. Daley +23 more
TL;DR: This work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis.
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Drosophila follicle cells: morphogenesis in an eggshell
TL;DR: Progress is summarized toward understanding mechanisms that maintain the epithelium or permit migrations essential for oogenesis, which is important for organogenesis and pivotal for carcinogenesis.
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Constitutive Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of Mesenchymal Tumors in Mice
Pradeep S. Tanwar,Ho-Joon Lee,Li Hua Zhang,Lawrence R. Zukerberg,Makoto Mark Taketo,Bo R. Rueda,José A. Teixeira +6 more
TL;DR: Evidence is shown suggesting that dysregulated, stromal, and myometrial WNT/beta-catenin signaling has pleiotropic effects on uterine function and tumorigenesis.
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Constitutive WNT/Beta-Catenin Signaling in Murine Sertoli Cells Disrupts Their Differentiation and Ability to Support Spermatogenesis
Pradeep S. Tanwar,Tomoko Kaneko-Tarui,Li Hua Zhang,Poonam Rani,Makoto M. Taketo,José A. Teixeira +5 more
TL;DR: It is shown that dysregulated wingless-related MMTV integration site/beta-catenin signaling in Sertoli cells inhibits their postnatal differentiation, resulting in increased germ cell apoptosis and infertility.
Journal ArticleDOI
Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance
Katia Meirelles,Leo Andrew Benedict,David Dombkowski,David Pépin,Frederic I. Preffer,José A. Teixeira,Pradeep S. Tanwar,Robert H. Young,David T. MacLaughlin,Patricia K. Donahoe,Xiaolong Wei +10 more
TL;DR: The results suggest that chemotherapeutics may be stimulative to cancer stem cells and that selective inhibition of these cells by treating with MIS or targeting LIN28 should be considered in the development of therapeutics.