2′-C-Methyluridine phosphoramidite: a new building block for the preparation of RNA analogues carrying the 2′-hydroxyl group
TLDR
A new stereoselective synthesis of 2′-C-methyluridine is expected to generate RNA analogues potentially useful in applications where proper RNA folding is required since the 2-hydroxyl group is conserved.About:
This article is published in Tetrahedron.The article was published on 2001-07-02 and is currently open access. It has received 77 citations till now. The article focuses on the topics: Phosphoramidite & RNA.read more
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6-modified bicyclic nucleic acid analogs
Eric E. Swayze,Punit P. Seth +1 more
TL;DR: In this article, the 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these analogs are presented. But they do not have (R) or (S)-chirality at the 6 position.
Patent
5′-modified bicyclic nucleic acid analogs
Punit P. Seth,Eric E. Swayze +1 more
TL;DR: In this article, the authors presented 5-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these analogs at the 5-carbon.
Patent
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
TL;DR: The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomerics hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA as mentioned in this paper.
Patent
Carbocyclic bicyclic nucleic acid analogs
Punit P. Seth,Eric E. Swayze +1 more
TL;DR: In this paper, saturated and unsaturated carbocyclic bicyclic nucleosides are used for enhancing properties of oligomeric compounds including nuclease resistance, and methods of using these compounds are described.
Patent
Methods and compositions for treating hepatitis C virus
TL;DR: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided in this paper.
References
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In vitro selection of RNA molecules that bind specific ligands.
TL;DR: Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules.
Journal ArticleDOI
Three-dimensional structure of a hammerhead ribozyme
TL;DR: The X-ray crystallographic structure of a hammerhead RNADNA ribozyme-inhibitor complex at 2.6 Å resolution reveals that the base-paired stems are A-form helices and the core has two structural domains.
Journal ArticleDOI
The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage.
TL;DR: The crystal structure of an all-RNA hammerhead ribozyme having a single 2'-O-methyl cytosine incorporated at the active site to prevent cleavage has been solved and a mechanism for RNA catalytic cleavage is proposed.
PatentDOI
Synthesis, deprotection, analysis and purification of RNA and ribozymes
Nassim Usman,Francine E. Wincott,David Sweedler,Leonid Beigelman,Lech W. Dudycz,Susan Grimm,Anthony Direnzo,Danuta Tracz +7 more
TL;DR: In this article, a method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form is presented, and the method is used to synthesize RNA molecules.
Journal ArticleDOI
Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead ribozymes.
TL;DR: Rozymes containing 2'-fluoro- or 2'-aminonucleotides at all uridine and cytidine positions were stabilized against degradation in rabbit serum by a factor of at least 10(3) compared to unmodified ribozyme.