Journal ArticleDOI
64 : Transgenic mice carrying interferon-regulated human MxA locus are highly resistant to avian but not human influenza A viruses
Christoph M. Deeg,Pascal Mutz,Carsten Kallfass,Cindy Nürnberger,Sébastien M. Soubies,Peter Staeheli +5 more
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TLDR
A new mouse line is created that carries the entire human Mx locus as a transgene and high levels of MxA were found in most organs of transgenic mice at 24 h post treatment with recombinant IFN-α but not in organs of untreated animals, indicating faithful regulation of the human MX locus in the authors' transgenic mouse.About:
This article is published in Cytokine.The article was published on 2013-09-01. It has received 4 citations till now. The article focuses on the topics: Influenza A virus & Avian Influenza A Virus.read more
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Journal ArticleDOI
Mx GTPases: dynamin-like antiviral machines of innate immunity
TL;DR: New structural and functional insights are focused on and recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses into the human population is discussed.
Journal ArticleDOI
Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection
Nurhafiza Zainal,Nurhafiza Zainal,Chih Peng Chang,Yi Lin Cheng,Yan Wei Wu,Robert Anderson,Robert Anderson,Shu Wen Wan,Chia Ling Chen,Tzong Shiann Ho,Sazaly AbuBakar,Yee Shin Lin +11 more
TL;DR: This is the first report to demonstrate that RESV antagonizes DENV replication and that nuclear HMGB1 plays a role in regulating ISG production.
Journal ArticleDOI
Poultry to Human Passport: Cross-species Transmission of Zoonotic H7N9 Avian Influenza Virus to Humans
TL;DR: Although zoonoses of H7N9 and other subtypes of avian influenza viral infections remain rare, the virus could acquire sufficient mammalian adaptive mutations to allow it to cause a future influenza pandemic.
Dissertation
Autoimmunity in the pathogenesis of severe dengue / Nurhafiza Zainal
TL;DR: In this article, the authors investigated the association of dengue and autoimmunity by comparing the genetic variant distribution among severe,======non-severe dengUE and systemic lupus erythematosus (SLE) patients using Ion Torrent sequencing method.