A 6-year follow-up of behavior and activity disorders in the Taiwan Yu-cheng children.
TLDR
In utero exposure to heat-degraded PCBs appears to cause mildly disordered behavior and increased activity level; the effect persists over time and is similar in children born up to 6 years after the mothers were exposed.Abstract:
OBJECTIVES. The relationship of behavior and activity levels to the interval between outbreak and year of birth and to age of children is explored in Taiwanese children exposed in utero to heat-degraded polychlorinated biphenyls (PCBs)--the Yu-cheng children. Additionally, the relationship of the scores to chemical, physical, and cognitive findings is described. METHODS. With Rutter's Child Behavior Scale A and a modified Werry-Weiss-Peters Activity Scale, 118 Yu-chen children and matched controls were followed biannually from 1985 to 1991. RESULTS. At each year, the Yu-cheng children scored 7% to 43% worse (mean = 23%) than control children on the Rutter scale. At any fixed age, the Yu-cheng children scored 11% to 63% (mean = 28%) worse. The effect for children born later did not differ from that for those born earlier; neither was there any improvement as the children aged. A similar but weaker picture was seen for the activity score. These behavioral findings were not related to physical or cognitive f...read more
Citations
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Toxicological profile for polychlorinated biphenyls (PCBs)
Obaid Faroon,James N. Olson +1 more
TL;DR: A toxicological profile for PCBs, Draft for Public Comment, was released in December 1998 as discussed by the authors, which supercedes any previously released draft or final profile, but no less than once every three years.
Journal ArticleDOI
Effects of PCB exposure on neuropsychological function in children.
TL;DR: It is revealed that the PCB residues in environmental media and human tissues may not closely resemble any of the commercial PCB mixtures, depending on source of exposure, bioaccumulation through the food chain, and weathering of PCBs in the environment.
Journal ArticleDOI
Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): implications for risk assessment.
TL;DR: Recent developments in the toxic equivalency factor (TEF) approach for the assessment of toxic effects due to dioxin-like PCBs have been examined and relative merits and implications of using TEF and total PCB approaches for assessing the potential for toxic effects in wildlife was examined.
Journal ArticleDOI
Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age
Svati Patandin,Caren I. Lanting,Paul G.H. Mulder,Eric Boersma,Pieter J. J. Sauer,Nynke Weisglas-Kuperus +5 more
TL;DR: In utero exposure to "background" PCB concentrations is associated with poorer cognitive functioning in preschool children, and children of mothers at the upper end of exposure are especially at risk.
Journal ArticleDOI
Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants
Donald T. Wigle,Tye E. Arbuckle,Michelle C. Turner,Annie Bérubé,Qiuying Yang,Shiliang Liu,Daniel Krewski +6 more
TL;DR: This review summarizes the level of epidemiologic evidence for relationships between prenatal and/or early life exposure to environmental chemical contaminants and fetal, child, and adult health and points to three main needs.
References
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Journal ArticleDOI
Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan
Walter J. Rogan,B. C. Gladen,Kun-Long Hung,Shin-Lan Koong,Ling-Yu Shih,J. S. Taylor,Ying-Chin Wu,D. Yang,N. B. Ragan,Chen-Chin Hsu +9 more
TL;DR: The exposed children showed delay of developmental milestones, deficits on formal developmental testing, and abnormalities on behavioral assessment, most consistent with a generalized disorder of ectodermal tissue.
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Epidemiologic study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls
TL;DR: The cause of the epidemic was soon demonstrated to be the ingestion of a brand of rice oil contaminated with a commercial brand of polychlorinated biphenyls, and the disease was called "Yusho", namely oil disease.
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Effects of exposure to PCBs and related compounds on growth and activity in children.
TL;DR: Activity is the first domain found to be affected by lactation at contemporary levels of exposure to polychlorinated biphenyls, an effect consistent with previous data linking developmental effects of low-dose human PCB exposures specifically to the prenatal period.
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Polychlorinated biphenyls and the developing nervous system: cross-species comparisons
TL;DR: Effects are roughly similar across species, but current methods used to calculate allowable or reference doses give results up to 4 orders of magnitude apart, with the lowest level based on the neurotoxicology level coming from the human data.
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Discovery and epidemiology of PCB poisoning in Taiwan: a four-year followup.
Shu-Tao Hsu,Chao-I Ma,Steve Kwo-Hsiung Hsu,Shih-Shium Wu,Nora Hsu-Mei Hsu,Ching-Chuan Yeh,Shang-Bang Wu +6 more
TL;DR: An outbreak of polychlorinated biphenyl (PCB) poisoning from the consumption of contaminated rice oil, covering four counties in central Taiwan, was investigated and 2061 persons were determined to be PCB poisoning victims.