Journal ArticleDOI
A comparison of metronidazole and sulfasalazine in the maintenance of remission in patients with ulcerative colitis.
TLDR
It is suggested that metronidazole may be useful in the maintenance of remission in patients with ulcerative colitis, but that it is ineffective in the therapy of the acute attack.Abstract:
In a double-blind, randomized trial, we tested the effectiveness of metronidazole (0.6 g/day) against sulfasalazine (2 g/day) in the maintenance of remission in patients with ulcerative colitis. The patients were in remission for 1-11 months at entry to trial, which lasted for 12 months. Forty patients entered the trial and 33 completed it. Metronidazole was found to be slightly more effective than sulfasalazine, a difference statistically significant only at 12 months. Six patients also completed a crossover trial. Remission was maintained for 12 months in 3 patients by metronidazole and in none of the 6 by sulfasalazine. No significant side effects were noted, and in particular, no paresthesias were reported. This trial, as well as our previous one, suggests that metronidazole may be useful in the maintenance of remission in patients with ulcerative colitis, but that it is ineffective in the therapy of the acute attack.read more
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Journal ArticleDOI
Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management
Axel Dignass,James O. Lindsay,Andreas Sturm,Alastair Windsor,Jean-Frederic Colombel,Mathieu Allez,G. D'Haens,André D'Hoore,Gerassimos J. Mantzaris,Gottfried Novacek,Tom Øresland,Walter Reinisch,Miquel Sans,Eduard F. Stange,Severine Vermeire,Simon Travis,Gert Van Assche +16 more
TL;DR: The most widely used index for severe UC remains that of Truelove and Witts3: any patient who has a bloody stool frequency ≥ 6/day and a tachycardia (> 90 bpm), or temperature > 37.8 °C, or anaemia (haemoglobin 30 mm/h) has severe ulcerative colitis (Table 1.3) as mentioned in this paper.
Second European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Current management
Axel Dignass,James O. Lindsay,Andreas Sturm,Alastair Windsor,Jean-Frédéric Colombel,Mathieu Allez,G. D'Haens,André D'Hoore,Gerassimos J. Mantzaris,Gottfried Novacek,Tom Øresland,W. Reinisch,Miquel Sans,Eduard F. Stange,Severine Vermeire,Simon Travis,Gert A. Van Assche +16 more
TL;DR: In this article, the authors presented a study of Gastroenterology at the University of Toronto and University of Leuven (Belgium) with the aim of identifying the cause of colorectal cancer.
Journal ArticleDOI
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
Malin E. V. Johansson,Jenny K. Gustafsson,Jessica Holmén-Larsson,Karolina S. Jabbar,Lijun Xia,Hua Xu,Fayez K. Ghishan,Frederic A. Carvalho,Andrew T. Gewirtz,Henrik Sjövall,Gunnar C. Hansson +10 more
TL;DR: The colon mucus in animal models that spontaneously develop colitis and in patients with active UC allows bacteria to penetrate and reach the epithelium, and this suggests a novel model of UC pathophysiology.
Journal ArticleDOI
European evidence-based Consensus on the management of ulcerative colitis: Current management.
Simon Travis,Eduard F. Stange,Marc Lémann,Tom Øresland,W. A. Bemelman,Yehuda Chowers,Jean-Frederic Colombel,Geert R. D'Haens,Subrata Ghosh,P. Marteau,Wolfgang Kruis,N. J. Mcc Mortensen,Freddy Penninckx,Miquel A. Gassull +13 more
TL;DR: The most widely used index for severe UC is Truelove and Wi_tts as discussed by the authors, which is defined as any patient who has a bloody stool frequency ≥ 6/day and a tachycardia (> 90 bpm), or temperature > 37.8 °C, or anaemia (haemoglobin 30 mm/h) has severe ulcerative colitis.
European-evidence-based consensus on the management of ulcerative colitis: Current management (vol 2, pg 24, 2008)
Simon Travis,Eduard F. Stange,Marc Lémann,Tom Øresland,W. A. Bemelman,Yehuda Chowers,J.-F. Colombel,Geert D'Haens,Subrata Ghosh,P. Marteau,Wolfgang Kruis,N. J. Mcc Mortensen,Freddy Penninckx,Miquel A. Gassull +13 more
TL;DR: The simplest, best validated and most widely used index for identifying acute severe UC remains that of Truelove & Wi_tts 3: any patient who has a bloody stool frequency ≥ 6/day and a tachycardia and temperature > 37.8 °C, or anaemia has severe ulcerative colitis.