F
Frederic A. Carvalho
Researcher at University of Auvergne
Publications - 33
Citations - 5025
Frederic A. Carvalho is an academic researcher from University of Auvergne. The author has contributed to research in topics: TLR5 & Gut flora. The author has an hindex of 16, co-authored 28 publications receiving 4294 citations. Previous affiliations of Frederic A. Carvalho include Emory University & Georgia State University.
Papers
More filters
Journal ArticleDOI
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Matam Vijay-Kumar,Jesse D. Aitken,Frederic A. Carvalho,Tyler C. Cullender,Simon M. Mwangi,Shanthi Srinivasan,Shanthi V. Sitaraman,Rob Knight,Ruth E. Ley,Andrew T. Gewirtz +9 more
TL;DR: Results support the emerging view that the gut microbiota contributes to metabolic disease and suggest that malfunction of the innate immune system may promote the development of metabolic syndrome.
Journal ArticleDOI
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
Malin E. V. Johansson,Jenny K. Gustafsson,Jessica Holmén-Larsson,Karolina S. Jabbar,Lijun Xia,Hua Xu,Fayez K. Ghishan,Frederic A. Carvalho,Andrew T. Gewirtz,Henrik Sjövall,Gunnar C. Hansson +10 more
TL;DR: The colon mucus in animal models that spontaneously develop colitis and in patients with active UC allows bacteria to penetrate and reach the epithelium, and this suggests a novel model of UC pathophysiology.
Journal ArticleDOI
CEACAM6 acts as a receptor for adherent-invasive E. coli , supporting ileal mucosa colonization in Crohn disease
Nicolas Barnich,Frederic A. Carvalho,Anne-Lise Glasser,Claude Darcha,Peter Jantscheff,Matthieu Allez,Harald Peeters,Gilles Bommelaer,Pierre Desreumaux,Jean-Frederic Colombel,Arlette Darfeuille-Michaud +10 more
TL;DR: In vitro studies show that there is increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC bacteria, indicating that AIEC can promote its own colonization in CD patients.
Journal ArticleDOI
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Frederic A. Carvalho,Frederic A. Carvalho,Frederic A. Carvalho,Omry Koren,Julia K. Goodrich,Malin E. V. Johansson,ILKe Nalbantoglu,Jesse D. Aitken,Yueju Su,Benoit Chassaing,William A. Walters,Antonio Gonzalez,Jose C. Clemente,Tyler C. Cullender,Nicolas Barnich,Arlette Darfeuille-Michaud,Matam Vijay-Kumar,Rob Knight,Rob Knight,Ruth E. Ley,Andrew T. Gewirtz +20 more
TL;DR: An innate immune deficiency can result in unstable gut microbiota associated with low-grade inflammation, and harboring proteobacteria can drive and/or instigate chronic colitis.
Journal ArticleDOI
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.
Jason Z. Oh,Rajesh Ravindran,Benoit Chassaing,Frederic A. Carvalho,Frederic A. Carvalho,Mohan S. Maddur,Maureen A. Bower,Paul Hakimpour,Kiran Gill,Helder I. Nakaya,Helder I. Nakaya,Felix Yarovinsky,R. Balfour Sartor,Andrew T. Gewirtz,Bali Pulendran +14 more
TL;DR: An unappreciated role for gut microbiota in promoting immunity to vaccination is revealed, with TLR5-mediated sensing of the microbiota impacting antibody responses to the inactivated polio vaccine, but not to adjuvanted vaccines or the live-attenuated yellow fever vaccine.