Journal ArticleDOI
A comparison of the properties of pyruvate kinase from hepatoma 3924-A, normal liver and muscle.
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This article is published in Life Sciences.The article was published on 1969-06-15. It has received 60 citations till now. The article focuses on the topics: Pyruvate dehydrogenase complex & Pyruvate dehydrogenase kinase.read more
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Journal ArticleDOI
Genetic and developmental control of multiple forms of L-glycerol 3-phosphate dehydrogenase.
Leslie P. Kozak,Joseph T. Jensen +1 more
TL;DR: The embryonic form of l-glycerol-3-P dehydrogenase is probably coded for by a genetic locus distinct from the locus for the adult enzyme, for although there is a difference in the rate of thermal denaturation for the enzyme from adult tissues of BALB/cBy and C57BL/6J mice, no strain-dependent differences are observed with the embryonic enzyme.
Journal Article
Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.
TL;DR: Emphasis is placed upon the apparent derepression of the fetal isozyme in hepatomas and the influence of neoplasms and their extracts on the expression of pyruvate kinase in the liver of host animals.
Book ChapterDOI
Isozymes And Cancer
TL;DR: The chapter describes the enzymes with multiple molecular forms (such as lactic, malate, isocitrate, alcohol, and aldehyde dehydrogenase respectively) and the isozymes present in both alkaline and acid phosphatases and presents a table summarizing the main distinctive isozymic modifications occurring in the serum of cancerous patients.
Journal ArticleDOI
Isozyme studies on adult, regenerating, precancerous and developing liver in relation to findings in hepatomas.
P. Roy Walker,Van R. Potter +1 more
TL;DR: Following controlled hyperplasia and differentiation after partial hepatectomy complete liver function is restored, whereas in the precancerous liver there is a loss of control of growth and differentiation in some cells resulting in hepatoma formation, which offers a rational explanation of the diverse phenotypes observed in the transplantable Morris liver hepatomas.
Journal Article
Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation- and progression-linked discriminants of malignancy.
TL;DR: Human PFK is both a transformation- and a progression-linked discriminant of malignancy, and as is the case with hexokinase and pyruvate kinase, the other two rate-limiting enzymes of glycolysis, PFK shows both quantitative increases and isozymic alterations secondary to altered gene expression during neoplastic transformation, both in vivo and in vitro.
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Book ChapterDOI
[66] Pyruvate kinase from muscle: Pyruvate phosphokinase, pyruvic phosphoferase, phosphopyruvate transphosphorylase, phosphate—transferring enzyme II, etc. Phosphoenolpyruvate + ADP ⇌ Pyruvate + ATP
Theodor Bücher,G. Pfleiderer +1 more
Journal Article
Comparative Biochemistry of Hepatomas IV. Isotope Studies of Glucose and Fructose Metabolism in Liver Tumors of Different Growth Rates
TL;DR: The metabolic fate of labeled fructose and glucose was compared in normal liver and in hepatomas of different growth rates, and for certain biochemical parameters a rough correlation with the growth rates of liver tumors was observed.
Journal ArticleDOI
Some distinctive properties of pyruvate kinase purified from rat liver
Journal ArticleDOI
Regulation of rat liver pyruvate kinase. The effect of preincubation, pH, copper ions, fructose 1,6-diphosphate and dietary changes on enzyme activity
TL;DR: Though phosphoenolpyruvate and fructose 1,6-diphosphate readily protect the enzyme against Cu(2+) inhibition, little evidence of significant reversal of the inhibition by these compounds could be found.