Journal ArticleDOI
Crystallization, Characterization and Metabolic Regulation of Two Types of Pyruvate Kinase Isolated from Rat Tissues
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This article is published in Journal of Biochemistry.The article was published on 1967-07-01. It has received 414 citations till now. The article focuses on the topics: Pyruvate kinase & Pyruvate dehydrogenase kinase.read more
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The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.
TL;DR: It is concluded that the M1- and M2-type isozymes of pyruvate kinase are produced from the same gene probably by alternative RNA splicing.
Journal ArticleDOI
PKM2, cancer metabolism, and the road ahead
TL;DR: The role that PKM2 plays in cells is discussed and a historical perspective for how the study of PKM1 has contributed to understanding cancer metabolism is provided and recent studies that raise important questions are reviewed.
Journal ArticleDOI
Pyruvate kinase: Function, regulation and role in cancer.
TL;DR: The structure, function, and regulation of pyruvate kinase are reviewed and how these properties enable regulation of PKM2 for cell proliferation and tumor growth are discussed.
Journal ArticleDOI
The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.
TL;DR: It is concluded that the L- and R-type isozymes of pyruvate kinase are produced from a single gene by use of different promoters.
Related Papers (5)
Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies.
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