Journal ArticleDOI
A concise synthesis of carpanone using solid-supported reagents and scavengers
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TLDR
In this article, a transition metal isomerisation catalyst is used for the synthesis of carpanone without the need for conventional purification techniques, and a new polymer-supported transition metal catalyst is also reported.Abstract:
Polymer-supported reagents have been applied to the synthesis of the natural product carpanone resulting in a clean and efficient synthesis without the requirement for conventional purification techniques. A new polymer-supported transition metal isomerisation catalyst is also reported.read more
Citations
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Controlled microwave heating in modern organic synthesis.
TL;DR: This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.
Journal ArticleDOI
Chemistry of Polyvalent Iodine
TL;DR: The present review summarizes the data that appeared in the literature following publication of previous reviews in 1996 and 2002 and is organized according to the classes of organic polyvalent iodine compounds with emphasis on their synthetic application.
Journal ArticleDOI
Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations.
TL;DR: This article describes the design, optimisation and development of a Suzuki cross-coupling protocol mediated by an efficient palladium-encapsulated catalyst (Pd EnCat) under microwave irradiation that enables a lower than normal bulk temperature to be maintained throughout the reaction period leading to significant improvements in the overall yield and purity of the reaction products.
Journal ArticleDOI
New tools and concepts for modern organic synthesis
Steven V. Ley,Ian R. Baxendale +1 more
TL;DR: Some of the general applications and approaches to synthesis using one technology — solid-supported reagents — that has been shown to significantly improve productivity in the generation of combinatorial libraries and complex target molecules are described.
References
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Journal ArticleDOI
Polymer-Supported Chiral Co(Salen) Complexes: Synthetic Applications and Mechanistic Investigations in the Hydrolytic Kinetic Resolution of Terminal Epoxides
TL;DR: In this article, the synthesis of polystyrene and silica-bound chiral Co(salen) complexes and their application in asymmetric catalysis was described, and a general method for the covalent attachment of salen complexes to both types of support has been devised, and the corresponding immobilized cobalt derivatives are shown to be efficient and highly enantioselective catalysts for the hydrolytic kinetic resolution (HKR) of terminal epoxides.
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Efficient oxidative biaryl coupling reaction of phenol ether derivatives using hypervalent iodine(III) reagents
TL;DR: Oxidative biaryl coupling reaction of phenol ether derivatives with the hypervalent iodine reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA), in the presence of BF3·Et2O gave a variety of substituted biphenyl and binaphthyl compounds in high yields.
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Total Synthesis of the Amaryllidaceae Alkaloid (+)‐Plicamine and Its Unnatural Enantiomer by Using Solid‐Supported Reagents and Scavengers in a Multistep Sequence of Reactions
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Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil.
Ian R. Baxendale,Steven V. Ley +1 more
TL;DR: Sildenafil 1 (Viagra), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purification methods.
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Solid-Phase Biomimetic Synthesis of Carpanone-like Molecules
TL;DR: In this article, the development of biomimetic reactions in the solid phase that result in one-step construction of tetracyclic molecules from readily accessible starting materials is reported.