Journal ArticleDOI
A consistent chromosome translocation in synovial sarcoma
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This article is published in Cancer Genetics and Cytogenetics.The article was published on 1987-05-01. It has received 111 citations till now. The article focuses on the topics: Chromosomal translocation & Synovial sarcoma.read more
Citations
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Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma
Jeremy Clark,P J Rocques,A J Crew,S Gill,Janet Shipley,Andrew K Chan,Barry A. Gusterson,Colin Cooper +7 more
TL;DR: Sequencing of cDNA clones shows that the normal SYT gene encodes a protein rich in glutamine, proline and glycine, and indicates that in synovial sarcoma rearrangement of the SYT genes results in the formation of an SYT–SSX fusion protein.
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Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor.
TL;DR: Investigating the histologic and immunohistochemical differentiation of Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) from other small, blue, round cell tumors found that FLI-1 protein expression is helpful in distinguishing ES/P NET from other tumors that may be CD99-positive, such as PDSS and RMS.
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A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin
TL;DR: Remarkably, within the skeletal muscle lineage, while expression of the oncoprotein in immature myoblasts leads to induction of synovial sarcoma with 100% penetrance, its expression in more differentiated cells induces myopathy without tumor induction.
Journal ArticleDOI
Molecular mechanisms underlying human synovial sarcoma development.
TL;DR: The molecular genetics methodology has now been applied to numerous tumor samples and has led to the finding that, in contrast to tumors carrying SYT-SSX2 fusions, SYT–SSX1–positive tumors more often exhibit a biphasic histology, show a higher proliferation rate, and are associated with a poorer clinical outcome
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Synovial sarcoma: defining features and diagnostic evolution
Khin Thway,Cyril Fisher +1 more
TL;DR: Correct diagnosis of Synovial sarcoma is clinically important, due to the relative chemosensitivity of SS in relation to other sarcomas, for prognostication and because of the potential for treatment with specific targeted therapies in the near future.
References
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Soft tissue tumors
TL;DR: In this article, the authors provide a clinical reference on soft tissue tumours, addressing tumours of the muscle, fat and connective tissue, and present a chapter on the molecular biology of soft tissue tumors.
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Soft Tissue Tumors
TL;DR: The comprehensive nature of the work includes not only soft-tissue tumors, in the traditional sense, but also provides extensive analyses of lesions that are peripheral to the tumor designation, most strikingly in the sections on fibrous proliferations and fibromatoses.
Book
Catalog of chromosome aberrations in cancer
TL;DR: This poster presents a probabilistic procedure to count the number of chromosomes in the nucleus using a simple “spatially aggregating” procedure called “spot-spot analysis”.
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Synovial sarcoma: Ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors
TL;DR: The use of electron microscopy can increase the specificity of immunohistochemical studies of soft tissue sarcomas and allow more accurate differentiation of monophasic synovial sarcoma from other spindle cell tumors, particularly those that do not express markers.
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Chromosome Changes in Soft Tissue Sarcomas
TL;DR: An analysis of chromosome aberrations in human tumors was performed in 29 cases of soft tissue sarcoma and it was impossible to reach any conclusion on the specificity of the cytogenetic abnormalities for a particular tumor type.