Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma
Claude Turc-Carel,P. Dal Cin,Janusz Limon,Uma Rao,Frederick P. Li,Joseph M. Corson,R Zimmerman,D.M. Parry,J M Cowan,Avery A. Sandberg +9 more
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The X;18 rearrangement appears to characterize the synovial sarcoma and is the first description of a primary, nonrandom change in the sex chromosome of a human solid tumor.Abstract:
A translocation that involves chromosome X (band p112) and chromosome 18 (band q112) was observed in short-term in vitro cultures of cells from five synovial sarcomas and one malignant fibrous histiocytoma In four of these tumors, the translocation t(X;18)(p112;q112) was reciprocal The two other tumors had complex translocations: t(X;18;21)(p112;q112;p13) and t(X;15;18)(p112;q23;q112) A translocation between chromosomes X and 18 was not detected in other histological types of soft tissue sarcoma The X;18 rearrangement appears to characterize the synovial sarcoma and is the first description of a primary, nonrandom change in the sex chromosome of a human solid tumorread more
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