Journal ArticleDOI
A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines
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This article is published in Tetrahedron Letters.The article was published on 1975-01-01. It has received 4417 citations till now.read more
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Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.
TL;DR: A novel regiospecific copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides on solid-phase is reported, and the X-ray structure of 2-azido-2-methylpropanoic acid has been solved, to yield structural information on the 1, 3-dipoles entering the reaction.
Journal ArticleDOI
Ionic liquid (molten salt) phase organometallic catalysis.
TL;DR: The advent of water-soluble organometallic complexes, especially those based on sulfonated phosphorus-containing ligands, has enabled various biphasic catalytic reactions to be conducted on an industrial scale and might combine the advantages of both homogeneous and heterogeneous catalysis.
Journal ArticleDOI
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla,Carmen Nájera +1 more
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
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Palladium-catalyzed cross-coupling reactions in total synthesis.
TL;DR: In this Review, highlights of a number of selected syntheses are discussed, demonstrating the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.
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Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize
TL;DR: This Review attempts to trace the historical origin of these powerful reactions, and outline the developments from the seminal discoveries leading to their eminent position as appreciated and applied today.
References
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Journal ArticleDOI
Palladium catalyzed synthesis of aryl, heterocyclic and vinylic acetylene derivatives
H.A. Dieck,F.R. Heck +1 more
TL;DR: In this paper, disubstituted acetylenes are converted into dis-ubstitized acetylene by reaction with aryl, heterocyclic or vinylic bromides or iodides at 100°C.
Journal ArticleDOI
The Substitution of Aryl Iodides with Cuprous Acetylides. A Synthesis of Tolanes and Heterocyclics1
R. D. Stephens,C. E. Castro +1 more
Journal ArticleDOI
Synthesis of aryl- and vinyl-substituted acetylene derivatives by the use of nickel and palladium complexes
TL;DR: In this paper, aryl and vinyl-substituted acetylenes are converted to a metal-triphenylphosphine (PTHP) complex under mild conditions.
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