Journal ArticleDOI
A lipid inhibitor of dengue virus in human colostrum and milk; with a note on the absence of anti-dengue secretory antibody
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Neutralizing activity against d Dengue virus types 1–4 was observed in milk samples from 5 non-immune and 29 dengue immune women and did not decrease over a period of ten months after delivery.Abstract:
Neutralizing activity against dengue virus types 1--4 was observed in milk samples from 5 non-immune and 29 dengue immune women. Anti-dengue activity in milk and colostrum was found only in the lipid component. The inhibitory activity is directed against the virus and not cell surfaces. When immunoglobulin types IgM,IgA, IgG were isolated from colostrum from dengue immune women, no antibody activity was found. Anti-dengue activity in human milk did not decrease over a period of ten months after delivery.read more
Citations
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Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides.
TL;DR: Studies are needed to establish whether human milk lipids have an antimicrobial effect in the stomach and intestines of infants and to determine what role, if any, they play in protecting infants against gastrointestinal infections.
Journal ArticleDOI
Protective Function of Proteins and Lipids in Human Milk
TL;DR: Several enzymes present in human milk might provide protection by generating components that are bactericidal (bile salt dependent lipase, peroxidase), prevent inflammatory reactions (platelet-activating factor acetylhydrolase), or protect the integrity of milk proteins (antiproteases).
Journal ArticleDOI
Protective factors in human breast milk and colostrum.
J.W.M Lawton,K.F Shortridge +1 more
Journal ArticleDOI
Protective function of human milk: the milk fat globule.
Margrit Hamosh,Jerry A. Peterson,Theresa R. Henderson,Ciaran D. Scallan,Radwin Kiwan,R L Ceriani,Martine Armand,Nifin R. Mehta,Paul Hamosh +8 more
TL;DR: Human milk contains many components that protect the newborn against infection at a time when the infant's own defense mechanisms are poorly developed, and the fat in human milk has a major protective function.
References
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Journal ArticleDOI
Studies on the Pathogenesis of Dengue Infection in Monkeys. III. Sequential Distribution of Virus in Primary and Heterologous Infections
TL;DR: The amount of intracellular infection increases toward the end of the viremic period, abruptly ending one to two days later, which correlates closely with the time of onset of shock in human dengue infection.
Journal Article
Observations related to the pathogenesis of dengue hemorrhagic fever. II. Antigenic and biologic properties of dengue viruses and their association with disease response in the host.
S. B. Halstead,P. Simasthien +1 more
TL;DR: Using single lots of mouse immune ascitic fluids, a large number of dengue viruses were tested by a plaque reduction neutralization test and the results were compared with the disease response and geographic origin of virus strains.
Journal Article
Observations related to pathogenesis of dengue hemorrhagic fever. I. Experience with classification of dengue viruses.
TL;DR: The hypothesis that DHF is due to a self-destructive host response has been proposed by Halstead and associates and suggested that some persons are sensitized by their first dengue infection.
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Paralytic Consequences of Poliomyelitis Infection in Different Parts of the World and in Different Population Groups
Journal ArticleDOI
The Antimicrobial Activity of Human Colostral Antibody in the Newborn
TL;DR: Bacterial counts in the stools of breast-fed infants were found to differ quantitatively and qualitatively from those of bottle-fed newborns, and existence of a direct correlation between the concentrations of immunoglobulins and reduction of coliform bacteria in theStools of breastfeeding newborns was observed.