Journal ArticleDOI
A Mode of Incipient Growth in Chemically Induced Signet Ring Cell Carcinoma of the Canine Stomach
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TLDR
Observance of a 31-month-old female mongrel dog revealed a mode of incipient gastric cancer growth, which starts and spreads within a single gland, before it invades the surrounding lamina propria.Abstract:
Summary A 31-month-old female mongrel dog was orally administered with 50 mg or 100 mg of N-nitrosobutylurea (NBU) in gelatin-capsule 3 times per week for 19 months with interposing periods of complete suspension.Thirty-four foci of signet ring cell carcinoma were found in the antral region of the stomach.The majority of the foci (31 foci) were early cancer, and the remaining foci were invasive cancer.In addition to these lesions, there was “a single gland cancer” in which a row of cancer cells was confined to a single gland.The whole gland was composed of two cell layers; the inner layer facing the lumen was normal gastric cells and the outer layer was atypical or neoplastic cells underlaid by the basement membrane.Mitosis was frequently observed on the bottom of the gland.Atypical or neoplastic cells seemed to mature gradually through a process of upward migration with increase in cytoplasmic Alcian blue-PAS and HID-AB positive mucin.Some of the cells rich in mucin moved into the lamina propria.The other cells remained in the flow of the regular cell renewal system of the normal gastric cells and reached the top of the gland.This observation revealed a mode of incipient gastric cancer growth, which starts and spreads within a single gland, before it invades the surrounding lamina propria.read more
Citations
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Journal ArticleDOI
Gastric epithelial dysplasia
Gregory Y. Lauwers,R H Riddell +1 more
TL;DR: Current issues related to gastric dysplasia, its definition, classification, grading, and natural history are reviewed, and new classifications of gastric epithelial Dysplasia designed to develop equivalence between grading schemes worldwide are discussed.
Journal ArticleDOI
Development of adenocarcinomas in the stomach.
TL;DR: It appears that most adenocarcinomas arise in gastric tubules when an abnormal differentiation is induced in stem cells after intestinal metaplasia, which implies that no precursor is present for each of them.
Journal ArticleDOI
Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
Stephen Nesnow,M. Argus,Hinda Bergman,K. Chu,C. Frith,T. Helmes,R. McGaughy,Verne A. Ray,Thomas J. Slaga,Raymond W. Tennant,E. Weisburger +10 more
TL;DR: The literature on 506 selected chemicals has been evaluated for evidence that these chemicals induce tumors in experimental animals and this assessment comprises the Gene-Tox Carcinogen Data Base, which was analyzed and examined according to chemical class.
Journal Article
Gastric epithelial dysplasia.
TL;DR: Current issues related to gastric dysplasia, its definition, classification, grading, and natural history are reviewed, and new classifications of gastric epithelial Dysplasia designed to develop equivalence between grading schemes worldwide are discussed.
Journal ArticleDOI
Gastrin receptor gene expression in several human carcinomas.
Yumi Matsushima,Yoshikazu Kinoshita,Hirohisa Nakata,Yoko Inomoto-Naribayashi,Masakyo Asahara,Chiharu Kawanami,Akira Nakamura,Mitsuhiro Ito,Toshimitsu Matsui,Takato Fujiwara,Hidenobu Watanabe,Tsutomu Chiba +11 more
TL;DR: None of the gastric adenocarcinomas tested had any detectable expression of gastrin receptor gene, which may suggest a role of Gastrin receptor in the growth and differentiation of certain human carcinomas.
References
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Journal ArticleDOI
Diamine methods for differentialing mucosubstances histochemically.
TL;DR: A mixture of N,N-dimethyl-rn-phenylenediamine (HCI)2 with the para isonter at pH 3.5-4.0 stains acid mucosubstautces selectively as mentioned in this paper.
Journal ArticleDOI
Tumour Production in Glandular Stomach of Rat by N -Methyl- N ′-Nitro- N -Nitrosoguanidine
Takashi Sugimura,Shinji Fujimura +1 more
TL;DR: The subcutaneous injection of a potent mutagen, N-methyl-N′-nitro-N-nitrosoguanidine (NG), into rats induced many transplantable sarcomas at the injected loci, according to the careinogenicity of this mutagen.
Journal ArticleDOI
Pathology of carcinoma of the stomach
TL;DR: The following account deals only with those phases of the subject which can be regarded as of importance in diagnosis and treatment and expresses chiefly the personal views and experience of the writer.
Journal ArticleDOI
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