Citations
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Journal Article
Animal models in type 2 diabetes research: an overview.
K Srinivasan,P Ramarao +1 more
TL;DR: This review gives an overview on the animal models of type 2 diabetes with reference to their origin/source, characteristic features, underlying causes/mechanism, advantages and disadvantages to the investigators in diabetes research.
Journal ArticleDOI
Metabolic Disorders and Adipose Tissue Insulin Responsiveness in Neonatally STZ-Induced Diabetic Rats Are Improved by Long-Term Melatonin Treatment
Ariclécio Cunha de Oliveira,Sandra Andreotti,Talita da Silva Mendes de Farias,Francisco Leonardo Torres-Leal,André Ricardo Gomes de Proença,Amanda Baron Campaña,Arnaldo H. de Souza,Rogério Antonio Laurato Sertié,Angelo Rafael Carpinelli,José Cipolla-Neto,Fábio Bessa Lima +10 more
TL;DR: Melatonin treatment was capable of ameliorating the metabolic abnormalities in this particular diabetes model, including insulin resistance and promoting a better long-term glycemic control.
Journal ArticleDOI
Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance.
Luiz F. Rezende,Gustavo J. Santos,Junia Carolina Santos-Silva,Everardo M. Carneiro,Antonio C. Boschero +4 more
TL;DR: CNTF protection against type 2 diabetes is partially independent of the anti-obesity actions of CNTF, requiring a reduction in insulin clearance and increased beta cell mass, besides increased insulin sensitivity.
Journal ArticleDOI
Anti-hyperglycemic effect of Potentilla discolor decoction on obese-diabetic (Ob-db) mice and its chemical composition.
TL;DR: The anti-hyperglycemic effects of a clinical active extract (decoction) from P. discolor significantly attenuated the increase of blood glucose and cholesterol levels in Ob-db mice, and this is the first evidence for the presences of sulfated flavonoid in P. Discolor decoction.
Journal ArticleDOI
Evaluation of 4-methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid against hyperglycemia, insulin sensitivity, and oxidative stress-induced inflammatory responses and β-cell damage in the pancreas of streptozotocin-induced diabetic rats.
Yam Nath Paudel,Md. Rahmat Ali,Sandhya Bawa,Sadia Shah,M Adil,A Siddiqui,A S Basheer,Md. Quamrul Hassan,Manju Sharma +8 more
TL;DR: The results suggest that BAC successfully reduces the blood glucose level and possesses antioxidant as well as anti-inflammatory activities, which leads to decreased histological damage in diabetic pancreatic tissues, suggesting the possibility of future diabetes treatments.
References
More filters
Journal Article
Animal models in type 2 diabetes research: an overview.
K Srinivasan,P Ramarao +1 more
TL;DR: This review gives an overview on the animal models of type 2 diabetes with reference to their origin/source, characteristic features, underlying causes/mechanism, advantages and disadvantages to the investigators in diabetes research.
Journal ArticleDOI
Metabolic Disorders and Adipose Tissue Insulin Responsiveness in Neonatally STZ-Induced Diabetic Rats Are Improved by Long-Term Melatonin Treatment
Ariclécio Cunha de Oliveira,Sandra Andreotti,Talita da Silva Mendes de Farias,Francisco Leonardo Torres-Leal,André Ricardo Gomes de Proença,Amanda Baron Campaña,Arnaldo H. de Souza,Rogério Antonio Laurato Sertié,Angelo Rafael Carpinelli,José Cipolla-Neto,Fábio Bessa Lima +10 more
TL;DR: Melatonin treatment was capable of ameliorating the metabolic abnormalities in this particular diabetes model, including insulin resistance and promoting a better long-term glycemic control.
Journal ArticleDOI
Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance.
Luiz F. Rezende,Gustavo J. Santos,Junia Carolina Santos-Silva,Everardo M. Carneiro,Antonio C. Boschero +4 more
TL;DR: CNTF protection against type 2 diabetes is partially independent of the anti-obesity actions of CNTF, requiring a reduction in insulin clearance and increased beta cell mass, besides increased insulin sensitivity.
Journal ArticleDOI
Anti-hyperglycemic effect of Potentilla discolor decoction on obese-diabetic (Ob-db) mice and its chemical composition.
TL;DR: The anti-hyperglycemic effects of a clinical active extract (decoction) from P. discolor significantly attenuated the increase of blood glucose and cholesterol levels in Ob-db mice, and this is the first evidence for the presences of sulfated flavonoid in P. Discolor decoction.
Journal ArticleDOI
Evaluation of 4-methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid against hyperglycemia, insulin sensitivity, and oxidative stress-induced inflammatory responses and β-cell damage in the pancreas of streptozotocin-induced diabetic rats.
Yam Nath Paudel,Md. Rahmat Ali,Sandhya Bawa,Sadia Shah,M Adil,A Siddiqui,A S Basheer,Md. Quamrul Hassan,Manju Sharma +8 more
TL;DR: The results suggest that BAC successfully reduces the blood glucose level and possesses antioxidant as well as anti-inflammatory activities, which leads to decreased histological damage in diabetic pancreatic tissues, suggesting the possibility of future diabetes treatments.