Journal ArticleDOI
A novel reagent for the synthesis of myo-inositol phosphates: N,N-diisopropyl dibenzyl phosphoramidite
Kuo-Long Yu,Bert Fraser-Reid +1 more
TLDR
It has been found that partially protected inositols are phosphorylated in near quantitative yields by use of N, N -diisopropyl dibenzyl phosphoramidite, 1- H -tetrazole and MCPBA in CH 2 Cl 2.About:
This article is published in Tetrahedron Letters.The article was published on 1988-01-01. It has received 170 citations till now. The article focuses on the topics: Phosphoramidite & Cyclitol.read more
Citations
More filters
Journal ArticleDOI
Recent developments in tetrazole chemistry. a review
TL;DR: In this paper, the authors present a review of recent developments in the Tatrazele CHEMISTRY and present an overview of the state-of-the-art.
Journal ArticleDOI
Regioselective protection and deprotection of inositol hydroxyl groups.
TL;DR: In this article, a survey and categorization of selective protection and deprotection reactions for cyclitol derivatives for the synthesis of various classes of natural and unnatural compounds with interesting properties is presented.
Journal ArticleDOI
Recent advances in the chemistry and biochemistry of inositol phosphates of biological interest.
Journal ArticleDOI
Stereoselective total synthesis of the glycosyl phosphatidylinositol (GPI) anchor of Trypanosoma brucei.
Chikara Murakata,Tomoya Ogawa +1 more
TL;DR: The total synthesis of the GPI anchor of Trypanosoma brucei was achieved for the first time and the introduction of two phosphodiester functions was efficiently achieved using the H-phosphonate method.
References
More filters
Journal Article
Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.
Journal ArticleDOI
Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+.
R F Irvine,R M Moor +1 more
TL;DR: Results show that inositol 1,3,4,5-tetrakisphosphate is an intracellular second messenger, and suggest that its function is to control cellular Ca2+ homoeostasis at the plasma membrane.
Journal ArticleDOI
The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P 3 3-kinase activity in animal tissues
TL;DR: It is suggested that an inositol tris/tetrakisphosphate pathway exists as an alternative route to the dephosphorylation10,11 of Ins(l,4,5)P3 3-kinase and the function of this novel pathway is unknown.
Journal ArticleDOI
Chemical 5′-phosphorylation of oligonucleotidesvaluable in automated DNA synthesis
E. Uhlmann,J. Engels +1 more
TL;DR: A new method has been developed for the chemical 5′-phosphorylation ofoligonucleotides starting from easily available phosphorous-III compounds using phosphate protecting groups which can be cleaved off via β-elimination.
Journal ArticleDOI
A new, convenient and efficient general procedure for the conversion of alcohols into their dibenzyl phosphorotriesters using N,N-diethyl dibenzyl phosphoramidite
John W. Perich,R. B. Johns +1 more
TL;DR: In this article, a general procedure for the nearquantitative preparation of alkyl dibenzyl phosphates was described by treating primary, secondary or tertiary alcohols with N,N-diethyl dibensyl phosphoramidite/1H,5-methyltetrazole.