A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart.
Michele Miragoli,Siti Hamimah Sheikh Abdul Kadir,Mary N. Sheppard,Nicolò Salvarani,Matilda Virta,Sarah Wells,Max J. Lab,Viacheslav O. Nikolaev,Alexey Moshkov,William M. Hague,Stephan Rohr,Catherine Williamson,Julia Gorelik +12 more
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TLDR
It is illustrated that the appearance of MFBs in the FH may contribute to arrhythmias, and the above‐described mechanism represents a new therapeutic approach for cardiac arrhythmic events at the level of M FB.About:
This article is published in Hepatology.The article was published on 2011-10-01 and is currently open access. It has received 77 citations till now. The article focuses on the topics: Fetal Arrhythmia.read more
Citations
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Journal ArticleDOI
Intrahepatic cholestasis of pregnancy
TL;DR: The epidemiology, clinical features, diagnosis, etiology and management of intrahepatic cholestasis of pregnancy are reviewed.
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Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study.
Victoria Geenes,Lucy C Chappell,Paul T. Seed,Philip J. Steer,Marian Knight,Catherine Williamson +5 more
TL;DR: Risks of preterm delivery, meconium‐stained amniotic fluid, and stillbirth rose with increasing maternal serum bile acid concentrations, supporting the case for close antenatal monitoring of pregnancies affected by severe ICP.
Journal ArticleDOI
Intrahepatic cholestasis of pregnancy.
TL;DR: Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester, and is associated with an increased risk of adverse perinatal outcomes.
Journal ArticleDOI
Pregnancy and liver disease
TL;DR: The risks of pregnancy in women with pre-existent liver pathology is detailed and recent advances in the understanding of specific risks and outcomes are discussed.
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Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial
Lucy C Chappell,Vinita Gurung,Paul T. Seed,Jenny Chambers,Catherine Williamson,Jim G Thornton +5 more
TL;DR: Ursodeoxycholic acid significantly reduces pruritus in women with intrahepatic cholestasis of pregnancy, but the size of the benefit may be too small for most doctors to recommend it, or for most women to want to take it.
References
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β2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation
Viacheslav O. Nikolaev,Viacheslav O. Nikolaev,Alexey Moshkov,Alexander R. Lyon,Michele Miragoli,Pavel Novák,Pavel Novák,Helen Paur,Martin J. Lohse,Yuri E. Korchev,Sian E. Harding,Julia Gorelik +11 more
TL;DR: In cardiomyocytes from healthy adult rats and mice, spatially confined β2AR-induced cAMP signals are localized exclusively to the deep transverse tubules, whereas functional β1ARs are distributed across the entire cell surface.
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Intrahepatic cholestasis of pregnancy
TL;DR: The epidemiology, clinical features, diagnosis, etiology and management of intrahepatic cholestasis of pregnancy are reviewed.
Journal ArticleDOI
Intrahepatic cholestasis of pregnancy
Thomas Pusl,Ulrich Beuers +1 more
TL;DR: The hydrophilic bile acid ursodeoxycholic acid (10–20 mg/kg/d) is today regarded as the first line treatment for intrahepatic cholestasis of pregnancy.
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Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin
TL;DR: It is illustrated that fibroblasts of cardiac origin are capable of synchronizing electrical activity of multicellular cardiac tissue over extended distances through electrotonic interactions, accompanied by extremely large local conduction delays, which might contribute to the generation of arrhythmias in fibrotic hearts.
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Human Semilunar Cardiac Valve Remodeling by Activated Cells From Fetus to Adult Implications for Postnatal Adaptation, Pathology, and Tissue Engineering
Elena Aikawa,Peter Whittaker,Mark Farber,Karen Mendelson,Robert F. Padera,Masanori Aikawa,Frederick J. Schoen +6 more
TL;DR: Fetal valves possess a dynamic/adaptive structure and contain cells with an activated/immature phenotype, which suggests a progressive, environmentally mediated adaptation.