Journal ArticleDOI
A randomized blinded comparison of two doses of antivenom in the treatment of Bothrops envenoming in São Paulo, Brazil
Miguel Tanús Jorge,João Luiz Costa Cardoso,S.C.B. Castro,L A Ribeiro,F.O.S. França,A.S. Kamiguti,Ida S. Sano-Martins,R.D.G. Theakston,David A. Warrell,M.E. de Almeida Sbrogio,Marcelo L. Santoro,J.E.C. Moncau +11 more
About:
This article is published in Toxicon.The article was published on 1996-01-01. It has received 10 citations till now. The article focuses on the topics: Antivenom & Bothrops.read more
Citations
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Journal ArticleDOI
Snake Antivenoms: Antivenoms
TL;DR: The concept of antivenoms was first developed by Henry Sewall in 1887 when he demonstrated that pigeons could be immunized against the effects of pygmy rattlesnake venom by successive inoculations of increasing doses of venom.
Journal ArticleDOI
Current treatment for venom-induced consumption coagulopathy resulting from snakebite.
TL;DR: Fresh frozen plasma appeared to speed the recovery of coagulopathy and should be considered in bleeding patients, and antivenom is the major treatment for VICC, but there is currently little high-quality evidence to support effectiveness.
Journal ArticleDOI
Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline?
Emilie Alirol,Pauline Lechevalier,Federica Zamatto,François Chappuis,Gabriel Alcoba,Julien Potet +5 more
TL;DR: The evidence for the efficacy and safety of existing and in-development snake antivenoms, and to list the alternatives to Fav-Afrique in sub-Saharan Africa, are reviewed.
Journal ArticleDOI
Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation.
TL;DR: The inflammatory effects and mechanisms induced by viper snake venoms, particularly from the Bothrops genus, are summarized, which strongly activate platelet functions and highlight selected venom components that both stimulate platelets functions and exhibit pro-inflammatory activities, thus providing insights into the possible role(s) of thromboinflammation in viper envenomation.
Journal ArticleDOI
Dose of antivenom for the treatment of snakebite with neurotoxic envenoming: Evidence from a randomised controlled trial in Nepal.
Emilie Alirol,Sanjib Kumar Sharma,Anup Ghimire,Antoine Poncet,Christophe Combescure,Chabilal Thapa,Vijaya Prasad Paudel,Kalidas Adhikary,Walter R. J. Taylor,David A. Warrell,Ulrich Kuch,François Chappuis +11 more
TL;DR: Although the high initial dose regimen is not more effective than the low initial dose, it offers the practical advantage of being a single dose, while not incurring higher consumption or enhanced risk of adverse reaction.
References
More filters
Journal ArticleDOI
Snake Antivenoms: Antivenoms
TL;DR: The concept of antivenoms was first developed by Henry Sewall in 1887 when he demonstrated that pigeons could be immunized against the effects of pygmy rattlesnake venom by successive inoculations of increasing doses of venom.
Journal ArticleDOI
Current treatment for venom-induced consumption coagulopathy resulting from snakebite.
TL;DR: Fresh frozen plasma appeared to speed the recovery of coagulopathy and should be considered in bleeding patients, and antivenom is the major treatment for VICC, but there is currently little high-quality evidence to support effectiveness.
Journal ArticleDOI
Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline?
Emilie Alirol,Pauline Lechevalier,Federica Zamatto,François Chappuis,Gabriel Alcoba,Julien Potet +5 more
TL;DR: The evidence for the efficacy and safety of existing and in-development snake antivenoms, and to list the alternatives to Fav-Afrique in sub-Saharan Africa, are reviewed.
Journal ArticleDOI
Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation.
TL;DR: The inflammatory effects and mechanisms induced by viper snake venoms, particularly from the Bothrops genus, are summarized, which strongly activate platelet functions and highlight selected venom components that both stimulate platelets functions and exhibit pro-inflammatory activities, thus providing insights into the possible role(s) of thromboinflammation in viper envenomation.
Journal ArticleDOI
Dose of antivenom for the treatment of snakebite with neurotoxic envenoming: Evidence from a randomised controlled trial in Nepal.
Emilie Alirol,Sanjib Kumar Sharma,Anup Ghimire,Antoine Poncet,Christophe Combescure,Chabilal Thapa,Vijaya Prasad Paudel,Kalidas Adhikary,Walter R. J. Taylor,David A. Warrell,Ulrich Kuch,François Chappuis +11 more
TL;DR: Although the high initial dose regimen is not more effective than the low initial dose, it offers the practical advantage of being a single dose, while not incurring higher consumption or enhanced risk of adverse reaction.
Related Papers (5)
A randomized blinded comparison of two doses of antivenom in the treatment of Bothrops envenoming in São Paulo, Brazil
Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in São Paulo, Brazil
João Luiz Costa Cardoso,Hui Wen Fan,F.O.S. França,Miguel Tanús Jorge,R. P. Leite,Sérgio de Andrade Nishioka,A. Avila,Ida S. Sano-Martins,S. C. Tomy,Marcelo L. Santoro,A M Chudzinski,S.C.B. Castro,A.S. Kamiguti,E. M. A. Kelen,Mario Hiroyuki Hirata,R. M. S. Mirandola,R.D.G. Theakston,David A. Warrell +17 more