Journal ArticleDOI
A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia.
Li Zhang,Timothy J Schallert,Zheng Gang Zhang,Quan Jiang,Polly Arniego,Qingjiang Li,Mei Lu,Michael Chopp,Michael Chopp +8 more
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TLDR
The data demonstrate that the corner test is a sensitive and objective test, which can be applied to evaluate long term functional outcome after stroke in the mouse, and highly predictive for infarct volume measured at 90 days after stroke.About:
This article is published in Journal of Neuroscience Methods.The article was published on 2002-06-30. It has received 374 citations till now. The article focuses on the topics: Cerebral blood flow & Middle cerebral artery.read more
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Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
Arthur Liesz,Elisabeth Suri-Payer,Claudia Veltkamp,Henrike Doerr,Clemens Sommer,Serge Rivest,Thomas Giese,Roland Veltkamp +7 more
TL;DR: Treg cells are major cerebroprotective modulators of postischemic inflammatory brain damage targeting multiple inflammatory pathways, and IL-10 signaling is essential for their immunomodulatory effect.
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Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: The data suggest that EPO-increased VEGF and BDNF may be involved in angiogenesis and neurogenesis, which could contribute to functional recovery.
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Animal models of neurological deficits: how relevant is the rat?
TL;DR: Rat models of hemiplegia, neglect and tactile extinction are useful in assessing the outcome of ischaemic or traumatic brain injury, and in monitoring the effects of therapeutic interventions.
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Functional assessments in the rodent stroke model
TL;DR: Many of the current behavioral tests that assess functional outcome after stoke in rodent models are reviewed to identify assessments that are sensitive to detecting the array of impairments, from global to modality specific, after stroke.
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Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice
Jieli Chen,Chunling Zhang,Hao Jiang,Yi Li,Lijie Zhang,Adam M. Robin,Mark Katakowski,Mei Lu,Michael Chopp,Michael Chopp +9 more
TL;DR: Data indicate that atorvastatin promotes angiogenesis, brain plasticity and enhances functional recovery after stroke, and VEGF, VEGFR2 and BDNF likely contribute to these restorative processes.
References
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Journal ArticleDOI
Reversible middle cerebral artery occlusion without craniectomy in rats.
TL;DR: Seven of eight rats that underwent permanent occlusion of the MCA had resolving moderately severe neurologic deficits and unilateral infarcts averaging 37.6 +/- 5.5% of the coronal sectional area at 72 hours after the onset of Occlusion.
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Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
Joshua B. Bederson,Lawrence H. Pitts,Miles Tsuji,Merry C. Nishimura,Richard L. Davis,Henry M. Bartkowski +5 more
TL;DR: In this article, the authors examined the incidence and size of infarction after occlusion of different portions of the rat middle cerebral artery (MCA) in order to define the reliability and predictability of this model of brain ischemia.
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Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
Zhihong Huang,Paul L. Huang,Nariman Panahian,Turgay Dalkara,Mark C. Fishman,Michael A. Moskowitz +5 more
TL;DR: In mutant mice deficient in neuronal NO synthase (NOS) activity, infarct volumes decreased significantly 24 and 72 hours after middle cerebral artery occlusion, and the neurological deficits were less than those in normal mice, which emphasize the importance of developing selective inhibitors of the neuronal isoform.
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Reactive oxygen radicals in signaling and damage in the ischemic brain.
TL;DR: Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury.
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CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury.
Timothy J Schallert,Sheila M. Fleming,J. Leigh Leasure,Jennifer L. Tillerson,Sondra T. Bland +4 more
TL;DR: A battery of useful tests for evaluating sensorimotor function and plasticity acutely and chronically in unilateral rat models of central nervous system injury are reviewed and OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test.