Abnormal Integrity of Corticocortical Tracts in Mild Cognitive Impairment : A Diffusion Tensor Imaging Study
Hyun Hee Cho,Dong Won Yang,Young Min Shon,Beum Saeng Kim,Yeong In Kim,Young Choi,Kwang-Soo Lee,Yong Soo Shim,Bora Yoon,Woo Jin Kim,Kook Jin Ahn +10 more
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TLDR
FA and MD values of DTI may be used as novel biomarkers for the evaluation of neurodegenerative disorders and microstructural changes of several corticocortical tracts associated with cognition were identified in patients with MCI.Abstract:
Mild cognitive impairment (MCI) has been defined as a transitional state between normal aging and Alzheimer disease. Diffusion tensor imaging (DTI) can estimate the microstructural integrity of white matter tracts in MCI. We evaluated the microstructural changes in the white matter of MCI patients with DTI. We recruited 11 patients with MCI who met the working criteria of MCI and 11 elderly normal controls. The mean diffusivity (MD) and fractional anisotropy (FA) were measured in 26 regions of the brain with the regions of interest (ROIs) method. In the MCI patients, FA values were significantly decreased in the hippocampus, the posterior limb of the internal capsule, the splenium of corpus callosum, and in the superior and inferior longitudinal fasciculus compared to the control group. MD values were significantly increased in the hippocampus, the anterior and posterior limbs of the internal capsules, the splenium of the corpus callosum, the right frontal lobe, and in the superior and the inferior longitudinal fasciculus. Microstructural changes of several corticocortical tracts associated with cognition were identified in patients with MCI. FA and MD values of DTI may be used as novel biomarkers for the evaluation of neurodegenerative disorders.read more
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A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
TL;DR: Case-control studies of diffusion tensor imaging in patients with Alzheimer's dementia (AD) and mild cognitive impairment (MCI) are reviewed to establish the relative severity and location of white matter microstructural changes.
Journal ArticleDOI
Longitudinal Assessment of Chemotherapy-Induced Structural Changes in Cerebral White Matter and Its Correlation With Impaired Cognitive Functioning
Sabine Deprez,Frédéric Amant,Ann Smeets,Ronald R. Peeters,Alexander Leemans,Wim Van Hecke,Judith Verhoeven,Marie-Rose Christiaens,Joris Vandenberghe,Mathieu Vandenbulcke,Stefan Sunaert +10 more
TL;DR: In this article, the cerebral white matter (WM) integrity before and after chemotherapy by using magnetic resonance diffusion tensor imaging (DTI) in combination with detailed cognitive assessment was studied.
Journal ArticleDOI
Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients
Sabine Deprez,Frédéric Amant,Refika Yigit,Kathleen Porke,Judith Verhoeven,Jan Van den Stock,Ann Smeets,Marie-Rose Christiaens,Alexander Leemans,Alexander Leemans,Wim Van Hecke,Joris Vandenberghe,Mathieu Vandenbulcke,Stefan Sunaert +13 more
TL;DR: It is shown that chemotherapy seems to affect WM integrity and that parameters derived from DTI have the required sensitivity to quantify neural changes related to chemotherapy‐induced mild cognitive impairment.
Journal ArticleDOI
Regionally-Specific Diffusion Tensor Imaging in Mild Cognitive Impairment and Alzheimer’s Disease
Michelle M. Mielke,Nicholas A. Kozauer,Kwun Chuen Gary Chan,M. George,J. Toroney,M. Zerrate,Karen Bandeen-Roche,Mei Cheng Wang,Peter vanZijl,James J. Pekar,Susumu Mori,Constantine G. Lyketsos,Marilyn S. Albert +12 more
TL;DR: Using DTI, findings indicate FA is decreased in specific fiber tracts among groups of subjects that vary along the spectrum from normal to AD, and that this measure is stable over short periods of time.
Journal ArticleDOI
Parietal cortex matters in Alzheimer's disease: an overview of structural, functional and metabolic findings.
TL;DR: A model showing the relationship between the various pathological events, as measured by different neuroimaging techniques, in the development of AD is proposed, which suggests myelin breakdown is a beginning of the chain of pathological events leading to AD pathology and an AD diagnosis.
References
More filters
Journal Article
A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients
Journal ArticleDOI
Aging, memory, and mild cognitive impairment.
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Emre Kokmen,Eric G. Tangelos +5 more
TL;DR: Evaluated the cognitive profiles of patients with mild cognitive impairment at the time of their initial diagnosis in an attempt to predict who would remain stable and who would evolve to AD, and results indicate that diagnostic criteria can be defined for patients who are likely to convert to AD.
Journal ArticleDOI
White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging
Marco Bozzali,Andrea Falini,Massimo Franceschi,Mara Cercignani,M Zuffi,G. Scotti,G. Comi,Massimo Filippi +7 more
TL;DR: White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas.
Journal ArticleDOI
Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging
Stephen E. Rose,Fang Chen,Jonathan B. Chalk,Fernando Zelaya,Wendy Strugnell,Mark Benson,James Semple,David M. Doddrell +7 more
TL;DR: Patients with probable Alzheimer's disease showed a highly significant reduction in the integrity of the association white matter fibre tracts, such as the splenium of the corpus callosum, superior longitudinal fasciculus, and cingulum, compared with normal controls.