F
Frédéric Amant
Researcher at Netherlands Cancer Institute
Publications - 644
Citations - 28964
Frédéric Amant is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Pregnancy & Cancer. The author has an hindex of 73, co-authored 592 publications receiving 23576 citations. Previous affiliations of Frédéric Amant include Nelson Mandela Academic Hospital & University Medical Center Groningen.
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Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Patient-derived xenograft models: an emerging platform for translational cancer research.
Manuel Hidalgo,Frédéric Amant,Andrew V. Biankin,Eva Budinská,Annette T. Byrne,Carlos Caldas,Robert Clarke,Steven de Jong,Jos Jonkers,Gunhild Mari Mælandsmo,Sergio Roman-Roman,Joan Seoane,Livio Trusolino,Alberto Villanueva +13 more
TL;DR: The current state of the art in this field is summarized, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and a European consortium of PDX models is introduced.
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ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up
Nicoletta Colombo,Carien L. Creutzberg,Frédéric Amant,Tjalling Bosse,Antonio González-Martín,Jonathan A. Ledermann,Christian Marth,Remi A. Nout,Denis Querleu,Mansoor Raza Mirza,Cristiana Sessa +10 more
TL;DR: The first joint European Society for Medical Oncology (ESMO), European SocieTy for Radiotherapy & Oncologies (ESTRO), and European Society of Gynaecological Oncologists (ESGO) consensus conference on endometrial cancer was held on 11-13 December 2014 in Milan, Italy, and comprised a multidisciplinary panel of 40 leading experts in the management of endometrium cancer as discussed by the authors.
Journal ArticleDOI
ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up.
Nicoletta Colombo,Carien L. Creutzberg,Frédéric Amant,Tjalling Bosse,Antonio González-Martín,Jonathan A. Ledermann,Christian Marth,Remi A. Nout,Denis Querleu,Mansoor Raza Mirza,Cristiana Sessa +10 more
TL;DR: Results of this consensus conference on endometrial cancer, together with a summary of evidence supporting each recommendation, are detailed in this article.
Journal ArticleDOI
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Annette T. Byrne,D Alferez,Frédéric Amant,Daniela Annibali,Joaquín Arribas,Andrew V. Biankin,Andrew V. Biankin,Alejandra Bruna,Eva Budinská,Carlos Caldas,David K. Chang,Robert Clarke,Hans Clevers,George Coukos,Virginie Dangles-Marie,S. Gail Eckhardt,Eva González-Suárez,Els Hermans,Manuel Hidalgo,Monika A. Jarzabek,Steven de Jong,Jos Jonkers,Kristel Kemper,Luisa Lanfrancone,Gunhild Mari Mælandsmo,Elisabetta Marangoni,Jean-Christophe Marine,Enzo Medico,Jens Henrik Norum,Héctor G. Palmer,Daniel S. Peeper,Pier Giuseppe Pelicci,Alejandro Piris-Giménez,Sergio Roman-Roman,Oscar M. Rueda,Joan Seoane,Violeta Serra,Laura Soucek,Dominique Vanhecke,Alberto Villanueva,Emilie Vinolo,Andrea Bertotti,Livio Trusolino +42 more
TL;DR: Patient derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology as mentioned in this paper, and the ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions.