Journal ArticleDOI
Absence of glucoprivic feeding after stress suggests impairment of noradrenergic neuron function
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TLDR
Feeding in response to 2-deoxy-D-glucose (2DG), a quantifiable behavior which appears to depend on noradrenergic (NE) neuron function, was used in these experiments to evaluate the functional capabilities of NE neurons after stress exposure, suggesting that NE neuron function may be impaired or temporarily abolished after severe stress exposure.About:
This article is published in Brain Research.The article was published on 1978-06-30. It has received 73 citations till now. The article focuses on the topics: Chronic stress.read more
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Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain
Jay M. Weiss,Prudence A. Goodman,Barbara G. Losito,Sheila A. Corrigan,Jonathan M. Charry,William H. Bailey +5 more
TL;DR: It is suggested that large stress-induced depletion of NE in the LC is involved in mediating behavioral depression brought about by severe stress, and induction of catecholamine-synthesizing enzymes — tyrosine hydroxylase (TH) and dopamine-β-hydroxylases (DBH) — in theLC may be a neurochemical mechanism to bring about recovery from poststress behavioral depression.
Journal ArticleDOI
Opioid modulation of appetite.
TL;DR: It is suggested that the feeding profile of the animal provides important clues as to whether or not the animal has an opiate-sensitive feeding system, and interactions with ingested nutrients and the milieu interieur provide an important means by which animals modulate the opiates-entrained feeding drives.
Journal ArticleDOI
Depression: The predisposing influence of stress
Hymie Anisman,Robert M. Zacharko +1 more
TL;DR: It is suggested that the effects of stressful experiences on affective state may be related to depletion of several neurotransmitters, including norepinephrine, dopamine, and serotonin, which contributes to behavioral depression.
Journal ArticleDOI
Brain Adrenergic receptors and resistance to stress
Eric A. Stone,Jane E. Platt +1 more
TL;DR: The hypothesis that a reduction in the number of brain adrenergic receptors is one of the biochemical factors underlying adaptation to stress is supported.
References
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Journal Article
Blockade of endogenous norepinephrine synthesis by alpha-methyl-tyrosine, an inhibitor of tyrosine hydroxylase.
TL;DR: Preliminary studies of the pharmacologic consequences of blockade of norepinephrine synthesis indicate impairment of motor activity and mild sedation in cats and guinea pigs and a reduction of the tyramine and nore Pinephrine pressor responses in guinea pig and rats.
Journal ArticleDOI
Localization of the primary metabolic block produced by 2-deoxyglucose.
TL;DR: One of the interesting features associated with the administration of 2deoxyglucose to eviscerated animals is that it leads to a marked reduction in the intracellular transfer of glucose despite the injection of maximal amounts of insulin, suggesting that 2-deoxyGLucose may be considered a metabolic block for glucose.
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Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain.
N. J. Uretsky,L. L. Iversen +1 more
TL;DR: The results are consistent with the evidence in the peripheral sympathetic nervous system that 6‐OHDA causes a selective destruction of adrenergic nerve endings and suggest that this compound may have a similar destructive effect on catecholamine neurones in the CNS.
Journal ArticleDOI
Increased feeding in response to decreased glucose utilization in the rat and monkey
GP Smith,AN Epstein +1 more
TL;DR: Since Z-DG produced marked hyperglycemia during the period of increased feeding, these results show that the abrupt onset of decreased glucose utilization, not hypoglycemia, is a sufficient condition for feeding in mammals.
Journal ArticleDOI
Eating or Drinking Elicited by Direct Adrenergic or Cholinergic Stimulation of Hypothalamus
TL;DR: A double cannula system, allowing repeated stimulation of central structures with crystalline chemicals, was developed to study the effects of adrenergic and cholinergic stimulation of the lateral hypothalamus of rats.
Related Papers (5)
Catecholamine depletion in mice upon reexposure to stress: mediation of the escape deficits produced by inescapable shock.
Hymie Anisman,Lawrence S. Sklar +1 more