Open AccessJournal Article
Abstract 6143: Regression of Aortic Valve Stenosis by ApoA-I Mimetic Peptide Infusions in Rabbits
David Busseuil,Yanfen Shi,Mélanie Mecteau,Geneviève Brand,Teodora Avram,Anne-Elen Kernaleguen,Eric Thorin,Jean-Gilles Latour,Eric Rhéaume,Jean-Claude Tardif +9 more
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In this paper, an experimental study was conducted to determine if apolipoprotein A•I (ApoA•I) mimetic peptide infusions could induce regression of aortic valve stenosis.Abstract:
Aortic valve stenosis (AVS) is the most common valvular heart disease, and standard curative therapy remains open heart surgical valve replacement. The aim of our experimental study was to determine if apolipoprotein A‐I (ApoA‐I) mimetic peptide infusions could induce regression of AVS.read more
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Journal Article
Effect of very high intensity statin therapy on regression of coronary atherosclerosis.
Dissertation
Évolution échocardiographique et prédicteurs de progression de la sténose valvulaire aortique
Dissertation
Sélection in vivo par phage display dans un modèle de sténose valvulaire aortique chez la souris pour la découverte de nouveaux peptides ciblant la valve aortique
TL;DR: This document catalogue les principaux droits de recherche de l'origine de l’origine du droit de L’Homme-Bretagne-Garonne, d’Hauts-de-Seine, enregistrée encyclopaedia des années moderne (23ès de Languedoc-Rouvray- sur-Sud).
Effects of an Angiotensin II Type 1 Receptor Blocker on Cardiovascular Calcification
TL;DR: Evidence is provided that ARBs robustly inhibit arterial calcification and this study is the first to suggest ARBs as a novel treatment option for those at risk for cardiovascular calcification, and suggests that ARB-treated animals had significantly increased valvular calcium.
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Journal ArticleDOI
Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.
Steven E. Nissen,Stephen J. Nicholls,Ilke Sipahi,Peter Libby,Joel S. Raichlen,Christie M. Ballantyne,Jean Davignon,Raimund Erbel,Jean Charles Fruchart,Jean-Claude Tardif,Paul Schoenhagen,Tim Crowe,Valerie A. Cain,Kathy Wolski,Marlene Goormastic,E. Murat Tuzcu +15 more
TL;DR: In this paper, the authors evaluated the effect of rosuvastatin on coronary atheroma burden using intravascular ultrasound (IVUS) imaging. And they found that very intensive statin therapy could regress coronary atherosclerosis as determined by IVUS imaging.
Journal ArticleDOI
Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial.
Steven E. Nissen,Taro Tsunoda,E. Murat Tuzcu,Paul Schoenhagen,Christopher J. Cooper,Muhammad Yasin,Gregory M. Eaton,Michael A Lauer,W. Scott Sheldon,Cindy L. Grines,Stephen H. Halpern,Tim Crowe,James C. Blankenship,Richard A. Kerensky +13 more
TL;DR: A recombinant ApoA-I Milano/phospholipid complex administered intravenously for 5 doses at weekly intervals produced significant regression of coronary atherosclerosis as measured by IVUS, and results require confirmation in larger clinical trials with morbidity and mortality end points.
Journal ArticleDOI
A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis.
S. Joanna Cowell,David E. Newby,Robin J Prescott,Peter Bloomfield,John H. Reid,David B. Northridge,Nicholas A. Boon +6 more
TL;DR: Long-term, large-scale, randomized, controlled trials are needed to establish the role of statin therapy in patients with calcific aortic stenosis, and this study cannot exclude a small reduction in the rate of disease progression or a significant reduction in major clinical end points.
Journal ArticleDOI
Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies.
TL;DR: There is compelling histopathologic and clinical data suggesting that calcific valve disease is an active disease process akin to atherosclerosis with lipoprotein deposition, chronic inflammation, and active leaflet calcification.
Journal ArticleDOI
Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial.
Jean-Claude Tardif,Jean Grégoire,Philippe L. L’Allier,Reda Ibrahim,Jacques Lespérance,Therese Heinonen,Simon Kouz,Colin Berry,Russell Basser,Marc-André Lavoie,Marie-Claude Guertin,Josep Rodés-Cabau,Efficacy (Erase) Investigators +12 more
TL;DR: Short-term infusions of reconstituted HDL resulted in no significant reductions in percentage change in atheroma volume or nominal change in plaque volume compared with placebo but did result in statistically significant improvement in the plaque characterization index and coronary score on quantitative coronary angiography.