Journal ArticleDOI
Access to racemic and enantioenriched 3-methyl-4-chromanones: catalysed asymmetric protonation of corresponding enolic species as the key step
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TLDR
Bronsted acids induced the intramolecular cyclisation of 3-aryloxypropanoic esters affording 3-methyl-4-chromanones, which have been transformed into the corresponding racemic benzyl β-oxoesters.About:
This article is published in Tetrahedron.The article was published on 2003-11-24. It has received 35 citations till now. The article focuses on the topics: Cascade reaction & Enantioselective synthesis.read more
Citations
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Combining transition metal catalysis and organocatalysis: a broad new concept for catalysis
Zhihui Shao,Hongbin Zhang +1 more
TL;DR: This critical review of the concept of combining transition metal catalysis and organocatalysis with several recent outstanding examples is illustrated, with the aim of shedding light on the synthetic utilities and potentials of this concept as a novel tool in organic synthesis.
Journal ArticleDOI
Asymmetric catalysis at chiral metal surfaces.
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When Organocatalysis Meets Transition‐Metal Catalysis
Cheng Zhong,Xiaodong Shi +1 more
TL;DR: In the past several years, applications of transition metal complexes in tuning the reactivity of organocatalyst-promoted transformations have attracted increasing attention in the synthetic community as discussed by the authors.
Journal ArticleDOI
Asymmetric domino reactions. Part B: Reactions based on the use of chiral catalysts and biocatalysts
TL;DR: This compilation clearly demonstrates the power and economical interest of asymmetric catalysed domino reactions in the field of synthetic organic chemistry including the asymmetric biocatalysed Domino reactions.
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Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities.
Saeed Emami,Zahra Ghanbarimasir +1 more
TL;DR: This review addresses the most significant synthetic methods reported on 4-chromanone-derived compounds and consequently emphasizes on the biological relevance of such compounds.
References
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Journal ArticleDOI
A facile synthesis of 3-alkylchromanones and chromones
TL;DR: In this article, a simple and high yielding route to 3-alkyl-3-phenyl-sulphonyl-4-chromanones has been achieved from 3-kalkyl, 3-pphenyl, and 3-naphyl, l-4 chromanones.
Journal ArticleDOI
An Efficient Process for the Synthesis of trans-2,3-Disubstituted-2,3-dihydro-4H-1-benzopyran-4-ones (Chroman-4-ones)
Richard W. Draper,Bin Hu,Radha V. Iyer,Xun Li,Yuelie Lu,Mohammad Ataur Rahman,Eugene J. Vater +6 more
TL;DR: The piperidine catalyzed Knoevenagel condensation of 2′-aryl/alkyl-2-hydroxyacetophenones 7 and aryl-alkylaldehydes 8 in refluxing isopropyl alcohol with azeotropic removal of water affords, in high yield, equilibrium mixtures of E - and Z -chalcones 9 and cis - and trans -chroman-4-ones 10 which are effectively isomerized in situ to the trans -2,3-diaryl/kylchroman 4-
Journal ArticleDOI
Acylation Reactions under Microwaves. 3. Aroylation of Benzene and Its Slightly Activated or Deactivated Derivatives
Julien Marquié,Christian Laporte,Andre Laporterie,Jacques Dubac,Jean-Roger Desmurs,Nicolas Roques +5 more
TL;DR: In this paper, a solvent-free aroylation of benzene and its slightly activated or deactivated derivatives has been carried out under microwave (MW) irradiation, in the presence of iron(III) chloride which, in these conditions, shows better activity than other metallic chlorides (in particular, AlCl3) with preferential interactions with polar species involved in the reaction.
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Asymmetric synthesis of cis-aminochromanol
Karl B. Hansen,Philippe Rabbat,Shawn A. Springfield,Paul N. Devine,Edward J. J. Grabowski,Paul J. Reider +5 more
TL;DR: In this article, an efficient asymmetric synthesis of cis-aminochromanol was achieved in seven steps by using the Co(III)-catalyzed phenol opening of methyl glycidate.
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Ring Transformation of Glycidic Amides with Ortho-Metalated Phenols to Enantiopure 3-Hydroxychromanones.
TL;DR: A novel access to hitherto unknown enantiopure 2-alkylchroman-4-ones was found by a reaction of ortho-metalated O-MOM-protected phenols with Weinreb amides of enantypure cis- or trans-glycidic acids.
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