Acute Bilirubin Encephalopathy and Its Progression to Kernicterus: Current Perspectives
Fatima Usman,Udochukwu Michael Diala,Steven M. Shapiro,Jean Baptiste Le Pichon,Tina M. Slusher +4 more
- Vol. 8, pp 33-44
TLDR
This work is distributed under the terms of the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/ 3.0/).Abstract:
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Citations
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Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia
TL;DR: In this article, the auditory brainstem responses (ABR) in relation to serum total bilirubin (TB) and unbound bilirubain (UB) levels in 66 non-asphyxiated full term infants at 3 to 5 days of age were sutdied and the latencies to wave I and V were averaged over two replications in each ear.
Journal ArticleDOI
High unbound bilirubin for age: a neurotoxin with major effects on the developing brain.
R. Cayabyab,Rangasamy Ramanathan +1 more
TL;DR: The neuropathological finding of bilirubin-induced neurotoxicity also includes cerebellar injury with a decreased number of Purkinje cells, and disruption of multisensory feedback loop between cerebellum and cortical neurons which may explain the clinical characteristics of autism spectrum disorders.
Journal Article
Bilirubin Induced Encephalopathy.
Parvaneh Karimzadeh,Minoo Fallahi,Mohammad Kazemian,Naeeme Taslimi Taleghani,Shamsollah Nouripour,Mitra Radfar +5 more
TL;DR: Beside the abnormal neurologic manifestations of the jaundiced neonates,brain MRI is the best imaging modality for the confirmation of the diagnosis of bilirubin induced encephalopathy (BIE).
Journal ArticleDOI
Early Amplitude-Integrated Electroencephalography Predicts Long-Term Outcomes in Term and Near-Term Newborns With Severe Hyperbilirubinemia.
Xiao Yuan,Juan Song,Liang Gao,Yanchao Cheng,Huimin Dong,Ruili Zhang,Shasha Liu,Xue Ding,Yong Wang,Falin Xu,Changlian Zhu,Changlian Zhu +11 more
TL;DR: Early aEEG could predict adverse neurodevelopmental outcomes in neonates with severe hyperbilirubinemia, although the sensitivity was lower than ABR.
References
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Journal ArticleDOI
Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation
TL;DR: These guidelines provide a framework for the prevention and management of hyperbilirubinemia in newborn infants of 35 or more weeks of gestation and recommend that clinicians promote and support successful breastfeeding and treat newborns with phototherapy or exchange transfusion to prevent the development of severe hyperbil Kirubin encephalopathy.
Journal ArticleDOI
The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome
[No Value] Chowdhury,S Gantla,A Deboer,Ba Oostra,Dick Lindhout,Gnj Tytgat,Plm Jansen,Rpjo Elferink,Nr Chowdhury +8 more
TL;DR: Reduced expression of bilirubin UDP-glucuronosyltransferase 1 due to an abnormality in the promoter region of the gene for this enzyme appears to be necessary for Gilbert's syndrome but not sufficient for the complete manifestation of the syndrome.
Journal ArticleDOI
Predictive Ability of a Predischarge Hour-specific Serum Bilirubin for Subsequent Significant Hyperbilirubinemia in Healthy Term and Near-term Newborns
TL;DR: An hour-specific predischarge serum bilirubin measurement before hospital discharge can predict which newborn is at high, intermediate or low risk for developing clinically significant hyperbilirubinemia (specifically defined as TSB levels ≥95th percentile for age in hours).
Journal ArticleDOI
Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels
Vinod K. Bhutani,Alvin Zipursky,Hannah Blencowe,Rajesh Khanna,Michael Sgro,Finn Ebbesen,Jennifer J. Bell,Rintaro Mori,Tina M. Slusher,Nahed Fahmy,Vinod K. Paul,Lizhong Du,A. A. Okolo,Maria Fernanda Branco de Almeida,Bolajoko O. Olusanya,Praveen Kumar,Simon Cousens,Joy E Lawn +17 more
TL;DR: Failure to prevent Rh sensitization and manage neonatal hyperbilirubinemia results in 114,100 avoidable neonatal deaths and many children grow up with disabilities.
Journal ArticleDOI
Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND).
TL;DR: The neurobiology of kernicterus, including the determinants and mechanisms of neuronal injury, is discussed along with traditional and evolving definitions ranging from classical kern commenterus with athetoid cerebral palsy, impaired upward gaze and deafness, to isolated conditions, for example, auditory neuropathy or dys-synchrony.