Showing papers in "Life Sciences in 1994"

TL;DR: Melatonin, which is a lipid-soluble compound, was twice more active than vitamin E, believed to be the most effective lipophilic antioxidant.

TL;DR: Results showed that some of the naturally occurring flavonoids and lignans inhibited HL-60 cell growth with a non-toxic mechanism, possibly via cessation of DNA, RNA, and/or protein synthesis of the leukemic cells.

TL;DR: The physiological role of the serotonin transporter on serotonin neuronal membranes apparently is to inactivate serotonin that has been released into the synaptic cleft, and serotonin neurons decrease their firing and release of serotonin to limit the magnitude of the increase in extracellular serotonin concentration.

TL;DR: Results suggest a new and important role of the pineal hormone melatonin on central nervous system processes, i.e., by modulating NO production.

TL;DR: The suitability of terephthalic acid (THA) as a hydroxyl radical dosimeter for general use in biologically relevant reactions is investigated and it is found that THA is non-fluorescent, eliminating the problem of a high initial background.

TL;DR: In vivo, SR 142801 potently inhibited the turning behaviour induced by intrastriatal injection of senktide in gerbils, and appears as a powerful tool for investigation of the physiological and pathological role of NKB and its NK3 receptor.

TL;DR: The existence of subtle, sometimes more pronounced, sex dimorphisms, fluctuations along the ovarian cycle and changes after gonadectomy and sex steroid replacement in CNr density and affinity in certain brain areas is revealed and supports the hypothesis of possible sex steroid-dependent differences in the sensitivity of certain neuronal processes to cannabinoid treatment.

TL;DR: It is demonstrated in this investigation that polyphenolic components of the Mediterranean diet interfere with biochemical events that are implicated in atherogenetic disease, thus proposing a new link between the Mediterranean Diet and prevention of CHD.

TL;DR: The frequency and pattern of expression of the SSTR mRNAs was virtually identical in the different tumor subclasses and did not correlate with tumor size, implying that SST analogs like SMS 201-995, known to interact with SSTR2A, but not with Sstr1, act on pituitary tumors mainly via the Sstr2 subtype.

TL;DR: These results systematically replicate and extend to humans prior findings in laboratory animals demonstrating that the availability of alternative, nondrug reinforcers can significantly decrease cocaine use.

TL;DR: Clinical studies indicate that the genetic or primary defect in MODY is characterized by deranged and deficient insulin secretion and not by insulin resistance and that there are quantitative and qualitative differences in insulin secretory defects which differentiate subjects with MODY due to glucokinase mutations from those with mutations in the gene on chromosome 20q.

TL;DR: Activity of bullatacin is shown in inhibition of NADH oxidase activity of plasma membrane vesicles isolated from HeLa cells and HL-60 cells but not with plasma membraneVesicle isolated from rat livers which, unlike the inhibition of mitochondrial activity, correlated with the ability of the acetogenins to kill tumor cells.

TL;DR: H7 prevented naloxone induced withdrawal jumping and reversed morphine (antinociceptive) tolerance in mice, affording potential separation of acute and chronic narcotic effects.

TL;DR: Findings indicate that Hexarelin is a highly effective GH releaser and might represent a valuable diagnostic and/or therapeutic tool in clinical practice.

TL;DR: The data suggest the possibility that adrenomedullin is a novel inhibitory peptide of aldosterone secretion induced by increasing concentration of intracellular free calcium.

TL;DR: Generalized activation of the immune system (raised expression of HLA class II antigens with elevated numbers of cytotoxic subpopulations (CD8 and NK lymphocytes) is present in women affected by premature menopause suggesting the involvement of autoimmune dysregulation in the pathogenesis of this syndrome.

TL;DR: A link is established between NO and the S-nitrosylation and mono-ADP-ribosylation of the enzyme glyceraldehyde 3-monophosphate dehydrogenase, which adds a further protein modification mechanism for NO action and adds a new dimension to NO in the communication of intracellular signals.

TL;DR: Results suggests that S-methadone does not essentially contribute to opioid effect of racemic methadone, and has a receptor binding profile which resembles that of morphine.

TL;DR: Test of the hypothesis that excretion of nitric oxide metabolites, nitrate and nitrite, are decreased with progressive aging in rats and that a decrease in Nitric oxide precursor, L-arginine, also decreases with aging confirms this hypothesis and suggests that nitrics oxide production may decrease with aging.

TL;DR: The contention that Bu as an endogenous antioxidant can prevent LDL oxidation and hence reduce the risk of atherogenesis is supported, and the effect of unconjugated bilirubin and Trolox on the oxidation of LDL after treatment with Cu2+ under defined conditions is compared.

TL;DR: The Y-1 receptor has recently been cloned and appears to mediate several effects of NPY including vasoconstriction and an anxiolytic effect in animal models of anxiety.

TL;DR: The 8-fold higher affinity of NTB relative to BNTX suggests that the human delta receptor is of the delta 2 subtype, andAgonists show binding to multiple affinity states of the receptor consistent with the presence of G-protein coupled and uncoupled forms of the expressed receptor.

TL;DR: Melatonin appears to send signals to the preoptic area of anterior hypothalamus where it adjusts the set point of Tb consistent with the metabolic rate of the animal, suggesting a new function for melatonin as a transducer mediating information about energy balance.

TL;DR: Observations suggest that S-oligo antisense compounds may display non-specific activating effects, at least on murine B cells, in addition to being dose-dependent and unaffected by T cell depletion.

TL;DR: It is proposed that a previously demonstrated reduction in the ischemia/reperfusion-evoked release of excitotoxic amino acids following CGS 15943 administration could account for its cerebroprotective actions.

TL;DR: It is demonstrated that ADM has significant vasodilator activity in the hindquarters vascular bed of the rat, that hindquarters vasodILator and systemic vasodepressor responses to ADM, but not to CGRP, are dependent upon the release of nitric oxide from the endothelium.

TL;DR: The results suggest that endogenous bloodborne Aβ can enter the CNS after associating with the capillary endothelium to accumulate intact within the parenchymal and CSF spaces of the brain.

TL;DR: It is suggested that chronic hypercholesteremia may stimulate DMA production through elevation of lipid peroxides, and implicate endogenous DMA as a contributor to the development of atherosclerosis.

TL;DR: It is suggested that CL 316,243 possesses anti-obesity and anti-diabetic effects and consequently may be useful for treating obesity as well as non-insulin-dependent diabetes mellitus in obese persons, without causing excessive side effects.

TL;DR: An antisense oligodeoxynucleotide directed against the 5'-untranslated region of MOR-1 clone, 51-70 bp upstream from the initiating ATG completely blocked the analgesic actions of morphine administered into the periaqueductal gray on Day 6 (p < 0.001), 24 hr after the last antisense treatment.