Journal ArticleDOI
Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice.
Masaharu Muranaka,Masaharu Muranaka,Shuji Suzuki,Shuji Suzuki,Kazuhiro Koizumi,Kazuhiro Koizumi,Shigeru Takafuji,Shigeru Takafuji,Terumasa Miyamoto,Terumasa Miyamoto,Ryosuke Ikemori,Ryosuke Ikemori,Hiroshi Tokiwa,Hiroshi Tokiwa +13 more
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TLDR
The results do indicate that the adjuvant activity of DEP can not be excluded as a possible cause of the associated change in the number of diesel cars and allergic rhinitis caused by pollen in Japan.Abstract:
The prevalence rate of allergic rhinitis caused by pollen has strikingly increased in Japan in the last three decades. The number of diesel cars in use has also rapidly increased in the country. This fact urged us to study the effects of particulates emitted from diesel cars on the production of IgE antibody. The primary IgE antibody responses in mice immunized with intraperitoneal injection of ovalbumin (OA) mixed with diesel-exhaust particulates (DEP) were higher than those in the animals immunized with OA alone. This effect of DEP on the production of IgE antibody in mice was also demonstrated when mice were immunized with repeated injections of dinitrophenylated-OA. In addition, persistent IgE-antibody response to major allergen of Japanese cedar pollen (JCPA), a most common pollen causing allergic rhinitis in Japan, was observed in mice immunized with JCPA mixed with DEP but not in the animals immunized with JCPA alone. The results do indicate that the adjuvant activity of DEP can not be excluded as a possible cause of the associated change in the number of diesel cars and allergic rhinitis caused by pollen in Japan.read more
Citations
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Allergic Rhinitis and Its Impact on Asthma
TL;DR: This systematic review and meta-analyses confirmed the findings of a previous study published in “Rhinitis and Asthma: Causes and Prevention, 2nd Ed.” (2015) as well as new findings of “Mechanisms of Respiratory Disease and Allergology,” which confirmed the role of EMTs in the development of these diseases.
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Air Pollution-Related Illness: Effects of Particles
TL;DR: In this article, Nel describes how the adverse effects of ultrafine air particles are linked to their ability to gain access to the lung and systemic circulation, where toxic components lead to tissue damage and inflammation.
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The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles.
Ning Li,Tian Xia,Andre E. Nel +2 more
TL;DR: The mechanisms by which particulate pollutants exert their adverse effects through the generation of oxidative stress and the impacts of oxidant injury in the respiratory tract will be reviewed and the importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will be discussed.
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Particulate air pollutants and asthma: A paradigm for the role of oxidative stress in PM-induced adverse health effects
TL;DR: The biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma are reviewed, with an emphasis on the pro-oxidative effects of diesel exhaust particles and their chemicals in the respiratory tract.
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Health effects of diesel exhaust emissions.
TL;DR: The research on adverse effects of diesel exhaust, both in vivo and in vitro, has however been conducted in animals, and questions remain concerning the relevance of exposure levels and whether findings in such models can be extrapolated into humans.
References
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Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans
Tai L. Chan,Morton Lippmann +1 more
TL;DR: Regional deposition of inhaled particles was studied experimentally in a hollow cast of the human larynx-tracheobronchial tree extending through the first six branching levels, and in twenty-six non-smoker human volunteers in vivo, indicating a linear dependence of particle deposition efficiency on the Stokes number for aerosols with aerodynamic diameters greater than 2 micrometers.
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Isolation and partial characterization of the major allergen from Japanese cedar (Cryptomeria japonica) pollen.
TL;DR: It was shown that antigen SBP was the major allergen of Japanese cedar pollen, and the four subfractions were seen to be antigenically and allergenicically identical.
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Homologous and heterologous passive cutaneous anaphylactic activity of mouse antisera during the course of immunization.
TL;DR: It is concluded that the 2 hour PCA activity of mouse antiserum in mice is due to 7Syl antibody whereas the 72 hourPCA activity in mice and the PCAActivity in rats are due to a heat labile reagin like antibody.
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Allergen carriage by atmospheric aerosol. I. Ragweed pollen determinants in smaller micronic fractions.
TL;DR: The data indicate the presence of airborne ragweed pollen allergen in aerosol fractions below 5 microns during seasonal periods of ragweed pollination, confirming the report of Busse et al.